ID A0A1X7UX45_AMPQE Unreviewed; 1453 AA.
AC A0A1X7UX45;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=FYVE-type domain-containing protein {ECO:0000259|PROSITE:PS50178};
GN Name=105312757 {ECO:0000313|EnsemblMetazoa:Aqu2.1.31937_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.31937_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.31937_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
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DR RefSeq; XP_019851973.1; XM_019996414.1.
DR STRING; 400682.A0A1X7UX45; -.
DR EnsemblMetazoa; Aqu2.1.31937_001; Aqu2.1.31937_001; Aqu2.1.31937.
DR GeneID; 105312757; -.
DR KEGG; aqu:105312757; -.
DR eggNOG; ENOG502QWB5; Eukaryota.
DR InParanoid; A0A1X7UX45; -.
DR OrthoDB; 2881467at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15730; FYVE_EEA1; 1.
DR Gene3D; 1.10.287.1490; -; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46753; FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46753:SF2; FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF69979; Eea1 homodimerisation domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 1394..1452
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 403..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 215..249
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 483..715
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1207..1259
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1320..1347
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 408..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..760
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1453 AA; 167276 MW; E1C7267EB9509229 CRC64;
MAAMLRNLNR RRKKEEQKAP SPSDPPLPAD SEGFICPICM EGLRSAEALQ VHWDAAHSEN
NKKTKEEEKK FEATLDGASA STPPVKKDQF PKRAQTGTQY IPELPSEGSD GELDTYRTMA
QEMIVLINEE RSVTGSLRSQ VSRLEDIVHK SDDQIREELV VMKQMFEQSE ESRATMSVEI
ARLSSQNTHL LKESETLSSN MEKVSQKAGT IAMTNANLQS KLDEAQSKIQ SLQQEMIKLQ
EKSGEQEVRN ERLAVQLQQR PEADDVKAMQ SQLSSLHIVM EQNSSEHELT VHKLNEEINK
LKNDKERLEE DLKKMTDHIQ TAPQVQDMTK LELQLSSLTS ELERVKNEKE SLTNQLESLQ
EKLSQYISPE TLQRYKKDVE RLESELNEKK MSLQSRDEQL SQLQSDLKMA PRRERVSELE
TELKESKDEG KKVIEELRNL ELRHQDVMNQ LSQMPTTQKL ESCEMKIREL ELELAGAPRQ
ERVTRLEEDL KQAQEQLNTL PKQQQLDSLQ AAIATLQSSL EQSNQQIKEK ESLILTLQEQ
LRKSQSDVSD REVSLVALQK ELEASQSSCS SKEQDLTVAQ KEARDLKRQI TSLEERLQSN
VIEINELKHK NEEETKRVSL LQTERTELIG KIEEGEGVST AISQLEQEKK SIEVKLESVL
KAASDKESDL HLKLEEINKS KTQVLEELED GRRQLKELES QLQKKEVALA SSQGKVDLLS
TELKTKESAL TELQRVTTQE QTKSQELLTR EKAKTESLTS DLEEVKNKFS EFKKTASEDE
ATLKKQLQTL QDQAQKQLTE ISSQLQQKTS ALQSLEDSSR EEKLRLESEL GLLQQNTATQ
KEELTSLQKS LEEARDQLVS SDASWRTDLD SERTKYRKEE ETLKAQLNNK ESELTSVQDE
RDKLRVSLEK CERNLDTSQT SLKEHQLKVQ ELEAAISRHE EQQKQLENNG KSLESELLQL
QASYKELEDK LSLQEATATN QLLEAEAKLE RKKSDHEELQ KSAKTVQDEL EATKKELEVK
KQKIEAQGNE HSQTLKQLEI KVDNETKLHS EINELQGLMA QKDTQIEDYE SSVTSLKEEV
ASLNTYFQQK SEYANSVEAE LKSKKEKVEE LETELAQLLN ELESKTQKYE EQLKELRDTV
KHHEDKEKAL ENELEGARTD FKHLNSQLDQ SEKTIQELTR TISERDSAIE SGRLELEQLG
KDRLNEKTSM ETEINSLQVQ LEQAKSETAQ VNFELSQLKS NYENLKAKLE KETADFKADL
GSAHSRIEVL DKENSELKTQ HEREVKTLSG NLGTLRFEME TMKQRVRDLD ENNSIQHKRI
NELTQLNNSL EDKNRSLLEK LVSEEEVRTR SSTQISDLQH RERELHSALQ QLGRENEKMQ
IVQRRQKQRQ WEKDEDVVSC HACQVKFSVS VRKHHCRHCG QIFCQKCTSQ SVMLPASKKP
QRVCNHCYKE LNK
//
