ID A0A1X7UX65_AMPQE Unreviewed; 953 AA.
AC A0A1X7UX65;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.31962_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.31962_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A1X7UX65; -.
DR EnsemblMetazoa; Aqu2.1.31962_001; Aqu2.1.31962_001; Aqu2.1.31962.
DR InParanoid; A0A1X7UX65; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047153; TRIM45/56/19.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25462; BONUS, ISOFORM C-RELATED; 1.
DR PANTHER; PTHR25462:SF266; TRANSCRIPTION INTERMEDIARY FACTOR 1-BETA; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 23..67
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 913..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 913..932
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 953 AA; 108425 MW; C01B307CF5530A1C CRC64;
MATRQSSPFP PDLMFKLEDQ LTCPVCLDHY FNPKTLPCLH SFCQQCIEVL PLDKKNETYY
LSCPICRHHT ELPKEGVGAF PVAFHLNNLK EIIMQAPDRT DGSHRFPHSL VAECMYNSDQ
RIVSALRQEM PTVAANKQGA LTMWMEEGSV DLTITRVNML GAPGSGKTCA QLLLLDEDPP
TEDDADSTSI SYPIRVAVDD ESMKWDQITR DKLLGGLAAD LIKASKKQSV AEVLSVDTHQ
LSPSKVSVSS KSRKDEVDYH VEEVVQEILA TKPVGIQLKG HWLYIIDLCG QPAYQELLPL
FTRAASLNII TLDLSRPFDE KFEMKYKIDG RYFPCCSKST QLASFQSSVS TSANFNSLDI
PSVTKEHGHS MHLVLGTHYD KVDETTLHEC EDSLKTSMSS LQPYLRDRII CNSTKSQESI
IFPVNTMAES EERAKYGEEI RQAIWLYGSG ASLTIKIPIR WFAFELSFPE KKRIISIKEA
LSIGERYGMK EEETMQTLLY FHDVSLMLYY PEVTDVVFVD PKPILNILSH LLALTYVNDG
SALKSILLEP LDQIVINHLK DGFFNEEIFT HLKCKSEIFC QPEFQLIDLI SLLLHLYIIT
KVEDNTKGNY FIPYALSSYQ GSAIPTVEVS NVQPLLIVWI DYESCESPPP PVPVPQGLFP
LAIMHLLNQK EFEIKLPSSR SNHHYFRFRD AMSIKITFNE IPYTLHLINR YTHIEVSFNG
PQKHCPNIRK LVMKAIGKVS DNLHMEHNYI NAFACIKDQE KKCYCIVVNE EQFIVNCTEC
PKPYPMTEDK CKCWFECVTA EINDPLITTF NHRLTIKDLN EVLNDLKSGG FSDESYFGLG
LELGLHHGTL NNIKSNNTKC EDQLRECISK WLMRSDDVDK RGGANWTMLC NAVEKMNRAA
ADYIRARHNI LTSQPIEQSS PQNHVEPDTQ TTGSDEGARR RYPLSFCKFY NYN
//
