ID A0A1X7UZF6_AMPQE Unreviewed; 1820 AA.
AC A0A1X7UZF6;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.32737_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.32737_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
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DR STRING; 400682.A0A1X7UZF6; -.
DR EnsemblMetazoa; Aqu2.1.32737_001; Aqu2.1.32737_001; Aqu2.1.32737.
DR eggNOG; KOG2044; Eukaryota.
DR eggNOG; KOG4475; Eukaryota.
DR InParanoid; A0A1X7UZF6; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd00096; Ig; 4.
DR CDD; cd18673; PIN_XRN1-2-like; 1.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 3.40.50.12390; -; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR004859; Xrn1_N.
DR PANTHER; PTHR12341:SF77; 5'-3' EXORIBONUCLEASE 2; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF17846; XRN_M; 1.
DR Pfam; PF03159; XRN_N; 1.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 4: Predicted;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1820
FT /note="Ig-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012191824"
FT TRANSMEM 636..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..124
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 231..291
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 531..621
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 676..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1216..1308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1584..1820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..696
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1252..1268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1269..1286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1294..1308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1647..1663
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1670..1687
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1820 AA; 203007 MW; C789F2DB1364C84F CRC64;
MARSNVLSFQ LVLCLSLLHF ATATHVDDII PLPSAIVSPS DSVIAINNQS FELNCTGTGT
LSWYRGFDFN TPLTNQSQLL DDNVTLSLTI TLSDDESGLM DERNRTYFCI ASNSLGVARS
HSVQIPFDTI PGGMNAFIAY RPPITNQYVS SQDSTISYFY IAATNGATEV GGSGAITPTM
QDGDLLRIRY TNTLVSTSGL NVILDRDSIN VDTSITVGYT VVDPLAVSDF PSVVNASSFH
RFESESISFT CMANGTNPRL SWYFNGLPLD HNDETLVLTN LSVANAGIYQ CFWDGFFEHE
RESVSWALSV QIPIPPRNIV LSVSQGTLID SNRTLLPTGL PATLDISFVS DSLPAVAWMY
TVDNVTVEIN FTNNTDYIAA GPVLVHKDED IYRISLTVNN VSASTSGFYH AVIDDSRTTP
TATHQWFVSQ YIPLSTPELS FGPFPCFLQS ESSFVTCSAQ SFPDPKITLI HSNNMLTNGI
TTFNQFTGLK IYTVTIRNSM ADAGIYTCQA TASNTTTPPA ADLDIKFCRK PTIESVPTLS
GNTNEPVNIN CTVNSAPTDD TKVTWSFNGV RIENSDRRRI ISVTGNIHQI RIISLQDSDA
GNYTCFVTNS LIPATASATI ALTVIPPPEA QDDFPILYVA VGVGGGVAIL LIVIIIIIAC
CVCCYIASKK KGNYNTTRPH LTKDYTDGRG NVDQDSDEED GGAEEPEAFQ PQYESLPALR
PAQPPQYKPS PAYNQGYGGE DIEMKKVPLP DFDDYPPQFY RQDNGGGGMM ASSVPIGSQR
KKLQGIDVPI DATLPNPNEV EFDNLYLDMN GIIHPCCHPE DKPAPETEDE MMVAIFEYID
RIFNIVRPRR LVYMAIDGVA PRAKMNQQRS RRFRSAKESV DKLEEIKKVR QELAERGVGL
PPLKPDSAHF DSNCITPGTQ FMANLAICLQ YYIHDRMNHN PAWKGLKVIL SDANVPGEGE
HKIMDYIRKQ RASVGHDPNT HHCLYGADAD LIMLGLATHE PYFTILREDF KPNQPRPCEI
CNQYGHSMTE CTGEAREKKG EFDELATANI AMEKEFIFIR INVLREYLQR ELRIDGLDFK
FDFERAIDDW VFMCFFVGND FLPHLPSLQI REGAIDRLIN LYKKFLPSTK SYLTENGFVD
VKNVQLILFE LGKVEDEIFI RRRDQDIRNK ERQKFKRRRI EDYKAPQFIP EQLAPVPIGS
APSPAVNARH DAYLMRQGPA PSAGAGGVSG SSLTSNKEAA KSMKSLLKKS KSFDDTGSSA
SQEGGGVRRS LTSEEERPRN TLKRSFSDAR RANSGGRGHG EDSGSEEDEV RLWEDGWKER
YYQSKFCVSS NDIDFVRQVV ESYSEGLCWV MSYYYQGCPS WKWYYPFHYA PFASDFRYIR
DVRDRFETGS KPFRPLEQLM SVFPAASAKF LPPSWQTLML DDDSSIIDFY PTNFKIDLNG
KKFAWQGVAL LPFVDECRLH EALEPLYHML DPLETVRNSL GNDLIFVHKL SKLYAFARTL
YEETPGEKVG LVSINPDSSG GVSGSVWPNN NMADILKKKE CLVESPLPQL ETITPTQAIC
LNYQDPTFRP DHIYESKLLP NVTMPPPTLR PGDARFGGIP GAYRPQIGFS PRDNRGRPYQ
TPPSAKRFIR NALSDESRSS TYHGVPPPPG SSYPPPQGPS VASWTPFPQP DFGNPRSQYS
GRARGSSQYS HGPRRPPPQQ YGQYGRDSGR QERSYNYSRD PRGSGYDPRG SGYDSRGSGY
DSRGSGYDPR GSGGQYGQYA SRDPMPYSYD RPPNEYHSFR QQQYKRPLLP PSPPPPSSSD
GYGKGHYDND GGSYPKRYHQ
//
