ID A0A1X7V054_AMPQE Unreviewed; 841 AA.
AC A0A1X7V054;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=CARD domain-containing protein {ECO:0000259|PROSITE:PS50209};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.33164_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.33164_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
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DR AlphaFoldDB; A0A1X7V054; -.
DR EnsemblMetazoa; Aqu2.1.33164_001; Aqu2.1.33164_001; Aqu2.1.33164.
DR eggNOG; KOG4369; Eukaryota.
DR InParanoid; A0A1X7V054; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001315; CARD.
DR PANTHER; PTHR24183; FIBRONECTIN TYPE 3 AND ANKYRIN REPEAT DOMAINS PROTEIN 1; 1.
DR PANTHER; PTHR24183:SF1; FIBRONECTIN TYPE 3 AND ANKYRIN REPEAT DOMAINS PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13857; Ank_5; 1.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50209; CARD; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 142..207
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REPEAT 565..597
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 598..630
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 643..675
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 751..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..795
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 796..815
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 841 AA; 92676 MW; 83002905936B085A CRC64;
MLLLLSGDVE LNPGPMIDDQ PDIFLLLQWL EPLVDWQPFG ILLPGITQWT IKAIEQLEAK
HQKLALFTKW LNTDPTATWR DVLNALTERE EINKYLLQTI NDQLQVHQCT GGNTDAPTST
VPVVSTVSSS VSVINKPVTS TTSGNPKDIL RTHSDTLVHA ISVNLYNVTD ALYAKELIPQ
QTKEEMHVLG VTNNEKSSKL VNVIEQQLES SLNPKQYLID ICHVLKNQQH RTLTDIATSI
LHQLGQSIPD NVSSHTVLPS PVNDISNTPV TNIRDPSVPN DSNGAAVSAT QREEIMFNTQ
EDEEQVSHSL IELHKAFASL MMEVQTAFDE RVASNPKVLI NLTRWIEAYM NWSDKLTNAS
LNGTFEIIHP FYDFIDCSLI VDMSEVFLQD FKNIVSELQN YKKKADKLRS SAQVKHLHDS
LQTIFEGHIP DTSNMPVILV KLRNPWGGNN IKGLSLLIHN LLPVGHQQSI MKYITILSGS
VIVKYSVYGS SADSLIEYTG GKEQFMRLIG IFSLYINGHP VLIEDENMNF TFELALLEAV
TAGNNEAVEF LLQLETVNID HTNEEGKTAL MLACERGHED IVHSLLSAGA NVNIQDNKGW
TTLMMASKHN HISIIHMLLQ ANANPHLKTS SGSKVDPNVQ NKDGVTALML ASANGHYEVV
KLLLEWEADP NINSNKGNTA LSLSKTSEIS ALIDGCMYKK GNIKLEEDDS SVSLQIAVPS
LYHITSDISR GSSLGSERTV SSGYLTASNI SSPISSFESP ETESFRCHTT SNISSKRSSS
TSSYSSAISS STSDSERAES TRHQTASDTK STSESERVES SGYGTASSIS STRNSPIQPQ
L
//
