ID   A0A1X7V0P7_AMPQE        Unreviewed;       837 AA.
AC   A0A1X7V0P7;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   28-JUN-2023, entry version 18.
DE   RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS   Amphimedon queenslandica (Sponge).
OC   Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC   Haplosclerida; Niphatidae; Amphimedon.
OX   NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.33157_001, ECO:0000313|Proteomes:UP000007879};
RN   [1] {ECO:0000313|Proteomes:UP000007879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20686567; DOI=10.1038/nature09201;
RA   Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA   Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA   Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA   Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA   Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA   Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT   "The Amphimedon queenslandica genome and the evolution of animal
RT   complexity.";
RL   Nature 466:720-726(2010).
RN   [2] {ECO:0000313|Proteomes:UP000007879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA   Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA   Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA   Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA   Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA   Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT   "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT   evolution of animal complexity.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.33157_001}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2017) to UniProtKB.
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DR   AlphaFoldDB; A0A1X7V0P7; -.
DR   EnsemblMetazoa; Aqu2.1.33157_001; Aqu2.1.33157_001; Aqu2.1.33157.
DR   eggNOG; ENOG502QTJW; Eukaryota.
DR   InParanoid; A0A1X7V0P7; -.
DR   Proteomes; UP000007879; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR46844; SLR5058 PROTEIN; 1.
DR   PANTHER; PTHR46844:SF1; SLR5058 PROTEIN; 1.
DR   Pfam; PF05729; NACHT; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        94..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          448..568
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   REGION          222..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        222..245
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   837 AA;  94568 MW;  E4783D35DC7EBBB9 CRC64;
     MIDVSQWRAS IGLWNYCQPA SSRPANGRHS HSFKAAVDSK SGSTTSGEKI SKLPAALSPI
     VSLLLSILRY MKFNFIPPTG IITVTVMIRC LQSLVLFIAT IGSSSDLIYC LVLFLLLLLS
     GDVELNPGPM IDDQPSCPLF AKYLEPLVDW ESFALCLPGG IGITQLDVDI IKRKGSSYLR
     MEALHKRWLQ VNPTASWRDV INVLKQCEEN ELARTIEDKM TYPTAGRSTN DDMEVSTSNA
     NPGPITGNPK DILRTHSVKL TDAVSGNLLR VTNELHAARL IPKLLRQEML VIGIDNYTKS
     TKLVNVIEQQ LKSSLNPEQY LIDICHVLIN QQHRTLTDIA TSILHQLGQS IPDNVTSISS
     IPDDVQGYAD NMRQHYKHQR IVATDWPPRI GKEYFGRLAL VEKKDCSTQA KSAWHMLRGQ
     VDKTAKLTEN KEISVEDILQ PTDNSLSLRV VIDGPPGIGK TTLCRKLLNM WSNGPLVHQQ
     YHLVLYCPLR DSKIATATTL ADLFVCQLNR FKNVPEWFEE RDGEGLLIIF DGWDELSEQL
     RQSSLAASII HRKQLDQCSV IVTSRSYASS SLLKMDTLSR HVQVIGFSEE EISTVIIQTL
     QKDTKLAQEI IQYLRSKSIP NSESDNESDE ISDDELVENK DSQLAVKLIN DLEVRNDVQS
     LCYVPLVCSM VILVYCKEGG HLPTTLTQLY ENFILQTIRR HVKRHDIDPH TLGSLSSLPS
     QLAKPLQEMC QLAYTNLANT RMTFSSHQLQ SLSEAVKEDY LGLMTTFTEY DEEMYQFLHL
     SIQEFLAAWW IAKHEKKTEE VFKDHFDDDN FQMCLRFVAG LTHLEHESYQ HVRGKLC
//