ID A0A1X7V1B6_AMPQE Unreviewed; 517 AA.
AC A0A1X7V1B6;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=phosphoethanolamine N-methyltransferase {ECO:0000256|ARBA:ARBA00035674};
DE EC=2.1.1.103 {ECO:0000256|ARBA:ARBA00035674};
GN Name=105312480 {ECO:0000313|EnsemblMetazoa:Aqu2.1.33741_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.33741_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.33741_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=phosphoethanolamine + S-adenosyl-L-methionine = H(+) + N-
CC methylethanolamine phosphate + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:20365, ChEBI:CHEBI:15378, ChEBI:CHEBI:57781,
CC ChEBI:CHEBI:57856, ChEBI:CHEBI:58190, ChEBI:CHEBI:59789;
CC EC=2.1.1.103; Evidence={ECO:0000256|ARBA:ARBA00035571};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20366;
CC Evidence={ECO:0000256|ARBA:ARBA00035571};
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004969}.
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DR RefSeq; XP_019851130.1; XM_019995571.1.
DR AlphaFoldDB; A0A1X7V1B6; -.
DR STRING; 400682.A0A1X7V1B6; -.
DR EnsemblMetazoa; Aqu2.1.33741_001; Aqu2.1.33741_001; Aqu2.1.33741.
DR GeneID; 105312480; -.
DR KEGG; aqu:105312480; -.
DR eggNOG; KOG1269; Eukaryota.
DR InParanoid; A0A1X7V1B6; -.
DR OrthoDB; 2249143at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR041698; Methyltransf_25.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR44307; PHOSPHOETHANOLAMINE METHYLTRANSFERASE; 1.
DR Pfam; PF13489; Methyltransf_23; 1.
DR Pfam; PF13649; Methyltransf_25; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 79..173
FT /note="Methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13649"
SQ SEQUENCE 517 AA; 58737 MW; 04A9F3BD11ECA650 CRC64;
MMEMEIDCSQ MIDVKKQDFS VVRKMMKDYW EDWAAYQTES GTTMELMVGE KHYNVAMQFY
DLDRMDVLGA LPKLAGMDVL ELGGGSGRYS GELAKRAKTV ISTDLIESFL KENEEKNGPS
HPNLSFRVLD AAQLDYPPAS FDMIFTNWLL MYLNDQDTER FIQNAIMMLR PGGYIFLRES
HFKPAGHRIQ SVNPTIYRSM MEYYDYFANV RYTDEKGDTY FFEFLNGGNC QTYVYRKANP
SQVFYLWRKT KVTQSPSMIS VQRLLDDALY SPENMTVYES VIGDGFMSPG GLDFSKELLS
KLNLTSDSVV LDVGCGLGGL ASYLIKECDV DCVGLELSMV ASQASILRLN SLSVNKGRMH
IADVVRTNFS ESSFDAIIAR ETIEYVGRKS LLFKKALSWL KPKGQLLLGE YCLGKMEPLS
IETEEILHSE GMDLLTIEDL TQLLKNAGYV NIKTEDYTHL YVQYIKEDLS KLTLTEGLPE
GVRIHFTNLW QTLVTALNNR ELAWTLVTAT SPDSEGR
//
