ID A0A1X7V2S6_AMPQE Unreviewed; 976 AA.
AC A0A1X7V2S6;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.34308_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.34308_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A1X7V2S6; -.
DR STRING; 400682.A0A1X7V2S6; -.
DR EnsemblMetazoa; Aqu2.1.34308_001; Aqu2.1.34308_001; Aqu2.1.34308.
DR eggNOG; KOG1056; Eukaryota.
DR InParanoid; A0A1X7V2S6; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060:SF134; G_PROTEIN_RECEP_F3_4 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 646..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..705
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 717..737
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 758..785
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 813..834
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 846..867
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 879..903
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 647..916
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 935..976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 976 AA; 107918 MW; BD81F7A34691FF45 CRC64;
MIFYSVLNSA AVYVDTSDKE VTVVGSKNCI KLIIKQNMVL LSSLLLLHSL LLCISGANYG
YRDASETVTL SGNRIRGARN RTDVDIVLGG LFPVHSVDDG GARCGSIRLE RGLERMEAML
YALDIINSNA SLLHGLKLGY DIRDTCSSEN IGLDESIDLV VSGQQLDLES CPTSDDTEYE
SANDSSEAAL PTSTVIGAAS SGVSVPVATL LRLFRIPQIS YASSSARLDN RDRYGYFYRT
ISPDSLQAEA MIDLCMEFNW TYVSTVYTND FYGEPGIDQF RKRAGETGIC IDVDEGINSD
SDDDDFSRIA SLLLASSTNV VVLFANQGNA RSLFSSIEAI NTANGTNKRF LWIASDAWAR
SISIVSLFNE SLAGLFGFAP YTDESQGFQD YYSQLTLESN QRNPFFPEFY QSYFNCTINK
TCNNTKPVTS HPRYQQGTFI PLVIDAVYSI AFAIRDYLND NCKQPIQWNR RTLSCDGNSD
RLNGSVLLRY LNNVSFISPT GRHITFNPET GNAAGGQYQI VNYQRFLNKS YGFVPVGIWN
GDNPNKRLSI NHSISQFGLE LINGQEVLLS RPRQSQCTVC TAGQYIVEVE GSCCGTCSNC
TGQEYSNTSS SSSCSTCPDR YWGNNPIIGS TSCVALEESY LRYRDAWSIV LMIMAIIGLI
SVVFVSVALG LYWNTPIVKS SGREQMILLL VGIALTFLTT FFFVSKPSTF VCFFQRSSLW
FCISFILASL LVKLIRISRI FLRQGSAASR PKFTEPRYQI LFTLLIVSIQ FIVVLISMIV
VYPLASEEQV ESNMAGGPPI IQVTCDSPHL APLIILALYH TALIIFCNIL AVVTIRFPEN
FNESKYVAFS TFSIGLIWLA FTQTYIATSN EDRTAVVSFA LNLSCFAVLL CMFGPRIVIM
IFFPERNVTQ FTTQPKSRGS TDINAQFDTG YITTLDPSLS VPTPKGSPRP TRVTLNLSDT
QQKSGNGSFD DNSTKL
//
