ID A0A1X7V3M0_AMPQE Unreviewed; 2400 AA.
AC A0A1X7V3M0;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:Aqu2.1.34603_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.34603_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.34603_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 400682.A0A1X7V3M0; -.
DR EnsemblMetazoa; Aqu2.1.34603_001; Aqu2.1.34603_001; Aqu2.1.34603.
DR eggNOG; KOG2242; Eukaryota.
DR InParanoid; A0A1X7V3M0; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 11.
DR CDD; cd12884; SPRY_hnRNP; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 20.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035234; IgGFc-bd_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035778; SPRY_hnRNP_U.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF166; VACUOLAR-SORTING RECEPTOR 1; 1.
DR Pfam; PF13671; AAA_33; 1.
DR Pfam; PF12662; cEGF; 5.
DR Pfam; PF07645; EGF_CA; 9.
DR Pfam; PF14670; FXa_inhibition; 5.
DR Pfam; PF17517; IgGFc_binding; 3.
DR Pfam; PF02037; SAP; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00181; EGF; 20.
DR SMART; SM00179; EGF_CA; 20.
DR SMART; SM00513; SAP; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 13.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS01186; EGF_2; 17.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 7.
DR PROSITE; PS50800; SAP; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2310..2341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..43
FT /note="SAP"
FT /evidence="ECO:0000259|PROSITE:PS50800"
FT DOMAIN 310..517
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1366..1405
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1406..1446
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1905..1943
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1944..1983
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2195..2234
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2235..2275
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 39..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 729..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..149
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..296
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1948..1958
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2400 AA; 261751 MW; D004B138D935A7E0 CRC64;
MSEDVEQYVQ KLKVTELREE LKKRGLGLGG VKAVLAQRLQ EAMEAEGETG NHKEPEEPAD
EEGDSEVDID RDANEPAVPQ SDEAPVNDTP DQEEEEEEKT EDDEADVKEE DEEGGGGNDG
EEEEEAVAND QDDDIKQEES EEESQATNDD ELVTVEPQES IKEETKTEEP MEEPTVDEEP
PPAEEPVTLQ EAKEEEPEVK PLADVPDGVT FVDDSSAQPK EEESMECSGG ASTQDGEEAK
SEAMAAESGM EGNNEEKPNQ DVDMKGSEDR GLKRIREESE GLDGDSKKEE TKVDPQTVPD
PESVADWSDE SIKEICSSLF LLPEDTTASV TLNPRKSDLH FIISSDGLGG APLTEGGFAY
LRASSKATWG VKSGSYYFEC KIEEKLPVDI EEEDENGGGE GEIVRKTEPS HNVRVGWSSL
DSDTIAGDDK NSFAYDSSGK KVTRSNSEDY GETFDEGDVI GCYVKLTDDS RTILFTKNGV
SQTEAFNLLE LNSESILFPH VSTRNYRVSF NFGGNPEPYY PPPDETYRPL QEAGEEEREC
VPNKPLSKNE CEVIMMVGLP GCGKTHWASR HASKNFDKAF RIIGPYQLLE RMLSKKRRSM
TNWNEFVLLT APMVNTLCLL ASNMPGNYII DQINVYADSQ KTKMSYFEGF SRKALVVIPP
HHELRKRRVD RIREGCCMEV PQNVIDAFKA NFHIPREDDG VFDEINFSEI YGPASDKIVR
QYKDDALGLP TPYIPSKRPR YESKGRSYSS PRPKPSPYGY GAYGSSSRYY PPPNRGYYAP
PPPPHYRSYY APPPPPPGAV SFSIKTSNGI FGSYSVNSSV PVDISLSTTL VTNDGLYSSR
FKGVYIYSTN GGLISVLVIN VRGSSTYGDY MAYPYQNLNL PEYQYYAVST GTLATLSDNS
LSEVLLVGNE DNTTVTVIPT QTVSVPIDIQ TNSNSKTVTA GSSFNFTIHR MQTFLIGAPL
LDISGTSIVS NKPLTVISDP CLSNNGGCDQ LCTSTFRSYA CSCHPGFSLD LNGYNCSDIN
ECDTNNGGCE QDCINTIGSY QCQCREGYET NNNGTNCTDI NECDTNNGGC EQDCINTVGS
YQCQCREGYE TNNNAINCTD VNECSLGTDG CNQNCVNTNG SYLCYCNAGY HLMSDQKTCA
DTNECLLNNG GCSQVCVNTI GSYNCSCNAG YQSIGQDCND INECTNGTHL CEHNCYNTNV
NLDTNECVTG NGNCSHDCTN TPGSYLCSCN NGYSIDTDGH NCTDINECDT NNGGCEQDCI
NTIGSYQCQC REGYETNNNG INCTDIDECI ANNNGGCDQN CFNTIGSYVC SCTDGYYLMS
DTLCVDINEC ATNNGGCEQI CTNQVPSFNC SCNNGYRLYN ERFCTDIDEC ADKNGGCEQI
CNNTLGSYQC SCLVGFTLTN DAFCSDINEC LLLDNRCSHD CVNTPGSHHC TCKDGYYLSN
DNHTCLILLQ NASAAYGTEF YVGAMRNYRG NTDELLLYVT TPSVSSVSFS IKTNNGIFGS
YSVNSSVPVD ISLPTSLVTN DGLYSSRFKG VYIYSTNGGL ISVLVINVRG TGSYGDYMAY
PYQNLNLSEY QYYAVSTGTL ATSDNSLSEV LLVGNEDNTT VTVIPTQTVS VPIDIQTNSN
SKAVTAGSSF TFTIHRMQTF LIGAPLLDIS GTSIVSNKPL TILPTIMWGR EFLLTPYATR
SGGPYFKVVA AFEDTSLNMT CSASEGNNFY LQNAGDVTTL YSSSSYCSII SNEPVLVTQL
GPSQDSGGSG NGDPVISLIP PIELHQQNIT LVIPGFSSIT NIYINIATAT KGPLYINGQL
QSVTWNNIYN NMSSIIGYGT QIPFNTISTS SSYTISMQTS FAALVYGFGN HHGYSYSAGI
NLTGNDPCLS NNGGCDQLCT STFGSYACSC HPGFSLDLNG YNCSDIDECA DSDCEHTCMN
TIGSYSCLCN DGYSLDMNNT SCSDINECTD YNDCEHICVN TIGNYSCLCH NGYTLDANNR
NCSEPTSYAT EFKVGFLRQF SSSSIIKMLV YTMSQEPVQF TISSASSYGF SYTGTTNISS
PNLLCTNTIG SYTCTCDNGY QLTNDNHTCT DIDECTLINN GGCEQTCHNT DGSYYCSCLN
GYSIDANGHD CTDINECVTD NGNCSHDCTN TPGSYLCSCN NGYSIDTDGH NCSDINECDA
NNGGCEQDCI NTMGSYQCQC REGFEFTSNG RSCTDIDECA DKNGGCEQTC NNTVGSFQCS
CLLGFTLAND AFCSDINECL LVDNRCSHDC VNTPGSYHCT CKGGYYLSND NHTCLTCGSG
NYLRNGSICE ALPTNIEATS GENVGSNTGF LYGAIGGVLI IIIIIIVVMA FVIIAIVLIV
IKNKRNGQYN VNQENQERSI YNTSNPMYND ENVDKCMEEK GDLYDYIDSP QTEKNEKLYV
//
