ID A0A1X7V5N9_AMPQE Unreviewed; 806 AA.
AC A0A1X7V5N9;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Sema domain-containing protein {ECO:0000259|PROSITE:PS51004};
GN Name=105312297 {ECO:0000313|EnsemblMetazoa:Aqu2.1.35291_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.35291_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.35291_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR RefSeq; XP_011403136.1; XM_011404834.2.
DR AlphaFoldDB; A0A1X7V5N9; -.
DR STRING; 400682.A0A1X7V5N9; -.
DR EnsemblMetazoa; Aqu2.1.35291_001; Aqu2.1.35291_001; Aqu2.1.35291.
DR GeneID; 105312297; -.
DR KEGG; aqu:105312297; -.
DR eggNOG; KOG3611; Eukaryota.
DR InParanoid; A0A1X7V5N9; -.
DR OMA; SFDINTH; -.
DR OrthoDB; 5399685at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF127; SEMAPHORIN-1A; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..806
FT /note="Sema domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010888053"
FT TRANSMEM 648..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..500
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 680..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..788
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 806 AA; 87378 MW; 1120BB9C9BBCD395 CRC64;
MKAALLLSSI FCLLVTASSS PNCRTVSYGR ACTGLSVTQL SLAGQVLLVG GNNSIYSFDT
SPRLEVKESF SIAPSSDRIS QCKIDTVTLD SSTECGNVVR VLQQVSSAAL SAAMLSNDSM
ETALNDSVMV CGTNAFYPKC TFHKIYNLSD WIEFETGNAL IGFSPYSVTS KSIGLLGSNG
RFYTGTNFGR FSTSFRISVA LHPLRFNRSF DINTHSSSPI WFSISSTDFV SIYEIGDYIY
VFLNEPAEEV DEGNSITYAR VVRFCKSDPG FLIGNIPPVL FSTFQKVRIT CSYSRHKSSP
KFYYDRIIST YLNWQNDSTP SPTLYATFSS SINGPEGTAV CKFSFDPTVT GNINSLFDSD
TQIKYYVTGS STTLAEEMEN AFVCPGKSGR QRSESESQRH QLLVGEVESS AILTRDGQTF
TSIVVDMFKY NNSVYEAVYV GTKDGRIFTS VFSNGKLFKT LDDIKLSNES VIEMLLSISN
ETKIRRIYAS TEGLVADVTH GNCSRYMTCM ECLESRDLYC SWQNGSCINK LLSKAQEAMN
PPSNTLDYCA PPNSASSTSI SIVFVPSSSN IPSKTVRTIT ASTTVSTSST RNAVSSTPIV
TVTRTTLVTT TRIILVTTEP VTSTLHAPTV QPTIGSVGTT TMPSVGEMVG GVIGGLLVGF
IIGSIICFVG LAVKRKLMKP EAVSTNETSN GGSTVTERRP RHRQGSVGHY TITVDLPGGG
QEEIKVIEEE DTGNENLSPP SPSVVVIDSE LEDDVITDLP IPGVSSNHKN KRGVSGRDRG
RTESTRWLRA SESEASTNGT ESPQSP
//
