ID A0A1X7V888_AMPQE Unreviewed; 667 AA.
AC A0A1X7V888;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011};
GN Name=105312126 {ECO:0000313|EnsemblMetazoa:Aqu2.1.36515_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.36515_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.36515_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
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DR RefSeq; XP_011402820.2; XM_011404518.2.
DR AlphaFoldDB; A0A1X7V888; -.
DR STRING; 400682.A0A1X7V888; -.
DR EnsemblMetazoa; Aqu2.1.36515_001; Aqu2.1.36515_001; Aqu2.1.36515.
DR GeneID; 105312126; -.
DR KEGG; aqu:105312126; -.
DR eggNOG; KOG0200; Eukaryota.
DR InParanoid; A0A1X7V888; -.
DR OrthoDB; 452559at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR24418:SF421; INACTIVE TYROSINE-PROTEIN KINASE WSCK-RELATED; 1.
DR PANTHER; PTHR24418; TYROSINE-PROTEIN KINASE; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..667
FT /note="Protein kinase domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012327050"
FT TRANSMEM 179..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 253..535
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 587..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 667 AA; 74427 MW; FFE40F77503A3199 CRC64;
MSSGWSSIFL CSFVFLTVSA TTQIQVLHVL EGEPFSISCN FPLPGFWTVS PLLVDTEGEG
ECTEPQIQTM LFTCSVYSAK LQNNGTYKVQ RFDNQFQTVC IFDIVVISIH QESSTALMTS
HYISSSFSSS SFAITSKTTM LMPLSTSNQL TSNLGTVSLH TSPLVTETPT DSQLQGTPIA
AIIVPVIAVG LLLSVSFIVL SAVLLLVMRF KRKKEPKSEE DNTGFLLGKR RSDLSEKDTN
SDKSSEIISF TSIVFEELIE KEKFSLVHHA SIKQKEVLVK QLKEKSAGHE ELMHEINLLK
KLNENGHHHM NIVSFIGTTE SPDPLILVME HLPHGTLKRL LVSLLKGPVP HWYFEHTLSS
QKGAYNNKQI SSDLFDILIQ VAKGAEYLSN NGLVHGHLST DNVILGRKLI AKLGNFTIPQ
SGDYFIKTER ENHLFDFAPE VISNGDHTMK SDIWSFGILT YKVATFETFQ PFSKIKPNEL
HSQLMEGTRP PPLPCFSNDL YCQMQQCWKA NKEERPDFSH VLSVLEILSK SDPWTHLVFE
ISEKRRSYVD ENQHIFLFPA PNQVPNTKKN TLLNNGRRIF ASSPQLMGME DMSGSEPSSE
NLDQRSGGAI GKGGKGSKLL ARKKSTTDDV SQLLVSQKKQ PNFDELEREL LAQGGGKIDR
TNPLISN
//
