ID   A0A1X7V900_AMPQE        Unreviewed;       859 AA.
AC   A0A1X7V900;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Amphimedon queenslandica (Sponge).
OC   Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC   Haplosclerida; Niphatidae; Amphimedon.
OX   NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.36468_001, ECO:0000313|Proteomes:UP000007879};
RN   [1] {ECO:0000313|Proteomes:UP000007879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20686567; DOI=10.1038/nature09201;
RA   Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA   Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA   Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA   Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA   Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA   Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT   "The Amphimedon queenslandica genome and the evolution of animal
RT   complexity.";
RL   Nature 466:720-726(2010).
RN   [2] {ECO:0000313|Proteomes:UP000007879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA   Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA   Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA   Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA   Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA   Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT   "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT   evolution of animal complexity.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.36468_001}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2017) to UniProtKB.
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DR   AlphaFoldDB; A0A1X7V900; -.
DR   STRING; 400682.A0A1X7V900; -.
DR   EnsemblMetazoa; Aqu2.1.36468_001; Aqu2.1.36468_001; Aqu2.1.36468.
DR   InParanoid; A0A1X7V900; -.
DR   Proteomes; UP000007879; Unassembled WGS sequence.
DR   GO; GO:0005929; C:cilium; IEA:GOC.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0035721; P:intraciliary retrograde transport; IEA:InterPro.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 1.25.40.470; -; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR040379; WDR19/dyf-2.
DR   PANTHER; PTHR14920; OSMOTIC AVOIDANCE ABNORMAL PROTEIN 1/WD REPEAT MEMBRANE PROTEIN; 1.
DR   PANTHER; PTHR14920:SF0; WD REPEAT-CONTAINING PROTEIN 19 ISOFORM X2; 1.
DR   Pfam; PF14529; Exo_endo_phos_2; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007879}.
FT   DOMAIN          11..122
FT                   /note="Endonuclease/exonuclease/phosphatase"
FT                   /evidence="ECO:0000259|Pfam:PF14529"
FT   DOMAIN          397..518
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|Pfam:PF00078"
SQ   SEQUENCE   859 AA;  97914 MW;  8BA97ADD0A3D28EE CRC64;
     MVQLNSSPPI LLCGVYLPPK SPASSIYALL SHLSSFSHLG PLILVGDFNF PDIDWSSFYA
     TCPSSRLFCN YLFTNNLVQL VDSPTHSHGH ILDLIVTSHP ELVTNITVGD ASCCNVSDHQ
     LVLFSVVSRI SSSRNKPSYY YKYNDADMDS ISSYLSSLTI TPTLQSDVES AWLFLKSSIT
     FARDNFVPIR YIPATTLPKW FDAELCHKLR QVRTLRRRVN KASHASEYLI HKLKHMESQL
     QLDIVSAKKH FLSRISSQYF SQPKILHSYL SSLKNSPTIP QSVHLGYQFS SDPQSRVTLF
     NNYFNSVFTK SDFLLPPLKD LPSPSSQLHY ISISSTDVLD SLNTLKLNKA PGVDDLSPSI
     IKLCSGPLLS SITSLFSNCL MYHKVPSEWK THKICPIPKS GDPSIVSNYR PISLLCILSK
     VLESIVYRKI IDFIQPLISK SQFGFLKSRS CLSQLLESFN YVFEGIENKN SVQAIYLDFK
     KAFDTVPHQE LLYKLWLHGI TGPLWKWSKL LYCSQLWSPR CLKDITRIET IQRRMTRFLV
     SSPHPLNYRD RLIDLQLLPL MYHHDLRDVL FIVKCLLSPP DNFDILQYVS FSTHGTRTTS
     TGKLKPHYGD ITSHAWFTND QVVLGFSKGF MIIVSRKKEE MGREMFQSRN HKGALNDIGI
     APSAPLLATA SNHQIKLHEF QDMQGMYGMV EIEDLKGKLD TIRLQSHFYS DSQDIIDSEI
     KLSFDKSLKL KKFKEAWSFA SALDSEDCWR ELRTAALYHF DIETAILASQ QMKDVSLVYS
     LKDISSVEDR NLVAGYIFMY KDEHSRAQEL FLESSEPTVA LDMQCDLLHW DQALELATAL
     DPSRIPMLSR QYAQQLESM
//