ID A0A1X7VAT3_AMPQE Unreviewed; 801 AA.
AC A0A1X7VAT3;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=SRCR domain-containing protein {ECO:0000259|PROSITE:PS50287};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.36632_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.36632_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00196}.
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DR AlphaFoldDB; A0A1X7VAT3; -.
DR EnsemblMetazoa; Aqu2.1.36632_001; Aqu2.1.36632_001; Aqu2.1.36632.
DR eggNOG; KOG3627; Eukaryota.
DR InParanoid; A0A1X7VAT3; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.10.250.10; SRCR-like domain; 6.
DR InterPro; IPR001190; SRCR.
DR InterPro; IPR017448; SRCR-like_dom.
DR InterPro; IPR036772; SRCR-like_dom_sf.
DR PANTHER; PTHR48071:SF18; LCCL_LECTIN ADHESIVE-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR48071; SRCR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00530; SRCR; 6.
DR PRINTS; PR00258; SPERACTRCPTR.
DR SMART; SM00202; SR; 6.
DR SUPFAM; SSF56487; SRCR-like; 6.
DR PROSITE; PS00420; SRCR_1; 5.
DR PROSITE; PS50287; SRCR_2; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00196}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 638..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..139
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 146..243
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 251..350
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 359..457
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 470..512
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT DOMAIN 537..635
FT /note="SRCR"
FT /evidence="ECO:0000259|PROSITE:PS50287"
FT REGION 685..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 752..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..790
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 214..224
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 321..331
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 428..438
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
FT DISULFID 606..616
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00196"
SQ SEQUENCE 801 AA; 85647 MW; 7A74CFAFB375FC19 CRC64;
MLLQYRGSPA ERNVLLIILV VCLNFIYIKG QCSQGSLRLV NGARYHEGRL EICYASSWGT
VCDDGWSNAN AQVVCRQLGY PTTGAYYRDR AYFGQGTGSI VLDDVSCVGN ETSLYQQCSH
RSPLSNDCTH SEDVGVVCPA PFDGSVRLVG GSNSSEGRVE VYRSGSWGTV CDDLWDYRDA
TVVCRQLGYG SGTALTDAYF GQGTGGIFMD DVACTGYELF LTNCSHTTSH NCGHHEDAGV
RCSHTCFSGS VRLVGGSNSF EGRVEVCSSG SWGTVCDDSW DYRDATVVCR QLGLGQASGT
AFSEAYFGQG TGSILMDDVA CTGSESYLTS CSHRTNHNCG HSEDAGVRCS QNCFTNGEVR
LVGGSNSFEG RVEVCRNGSW GTVCDNSWDY RDATVVCRQL GLGSSGIAFS NAYFGQGTGS
IVMDNVRCTG SESYLTSCSH RIFHNCDHSE DAGVRCSYCK DYTVCIDGEV RLVGGSSSLE
GRVEVCRNGL WGTVCDDSWG TNDATVVCRQ LGYDLTAIGA RPRTVGVSFA VCIDGEVRLV
GGSSSLEGRV EVCRNGSWGT VCDDSWDTND ATVVCRQLGY DLTGTAYSNA YFGAGTGRIL
MDDVACTGSE SYLTNCSHTT NHNCRHSEDA GVICGLRAFL GIMIGGAIGG IVFLLFVFAM
IVICVAVLHS KLSLSGTRAR QAAPAVQMTS LPAQTTSTTT GAYTQSQPKA ENQPLPPSYS
DYMEQQTQPT APMAYPGYAA PAVGFAVQGY PQQDYSQTGY PQQQQQEAPV GYPQQEPQGY
GGTNPGTDES TGIRDEPPPP Y
//
