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Database: UniProt
Entry: A0A1X7VBQ9_AMPQE
LinkDB: A0A1X7VBQ9_AMPQE
Original site: A0A1X7VBQ9_AMPQE 
ID   A0A1X7VBQ9_AMPQE        Unreviewed;      2642 AA.
AC   A0A1X7VBQ9;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   16-JAN-2019, entry version 10.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EnsemblMetazoa:Aqu2.1.37461_001};
OS   Amphimedon queenslandica (Sponge).
OC   Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC   Haplosclerida; Niphatidae; Amphimedon.
OX   NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.37461_001, ECO:0000313|Proteomes:UP000007879};
RN   [1] {ECO:0000313|EnsemblMetazoa:Aqu2.1.37461_001, ECO:0000313|Proteomes:UP000007879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E.,
RA   Glavina del Rio T., Bruce D., Barry K., Pitluck S., Srivastava M.,
RA   Simakov O., Chapman J., Mitros T., Hellsten U., Putnam N.H., Fahey B.,
RA   Gauthier M., Larroux C., Richards G.S., Stanke M., Adamska M.,
RA   Darling A., Dacre M., Degnan S.M., Zhai Y., Adamski M., Calcino A.,
RA   Cummins S.F., Goodstein D.M., Harris C., Shu S., Woodcroft B.,
RA   Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT   "The genome of the haplosclerid demosponge Amphimedon queenslandica
RT   and the evolution of animal complexity.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:Aqu2.1.37461_001}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2017) to UniProtKB.
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DR   RefSeq; XP_019849736.1; XM_019994177.1.
DR   EnsemblMetazoa; Aqu2.1.37461_001; Aqu2.1.37461_001; Aqu2.1.37461.
DR   GeneID; 100632615; -.
DR   KEGG; aqu:100632615; -.
DR   OrthoDB; 94996at2759; -.
DR   Proteomes; UP000007879; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007879};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2226   2246       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2267   2290       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2337   2364       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2385   2407       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2466   2489       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      142    195       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      270    334       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      340    393       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      397    452       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       77     97       {ECO:0000256|SAM:Coils}.
FT   COILED      112    144       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2642 AA;  303339 MW;  95509C2FCC8401C6 CRC64;
     MAGAGSARQT SLRIGDTVLF QVSSGRESRE KTGYIYSELS SSPFNFMTVY PVNQGSELEP
     DFPNIAFATF KVMVPNKYKA KQRLQKLMEE KRKKQASAAP DSPTGSMKNR SESQYTRLLH
     QAKEQAEEEE MENAQEQARR AGTKVVYGDL IQLQHVASGK FVNVRSEASK TESNNLLVNL
     SEENSDGCSF VILPRYKVRS EGDEIRFSDQ MKLESFKTKG QFLSCSFGQR TLYAAGFYTH
     PNFYELNLSA TESALTLIPH SCPSVNKHPD NALRAGGVVR LFHREDECYI VAEGSFANDA
     TPTENVHCRQ RRVDQRKHGN PSTSANTYWQ IEKEEDPRTG EVLYWEERCR LKHLPTRLYL
     AVCKDERGNY EVTLKRRKFD ATDLDTLFSF HALIEEGIEV LLESYARIKH LVSGRWLHLV
     DEKYTRKNFD PTAVGLAGLQ WDFAELFQLT TSKNEEDYDA FTLQEVPFDL LRRFNYVAGI
     SPVLTSHIKF LQSGNGAAIP QKQASRVKQT IAELKDSILT LSDRDTKNNQ KLLRNIQVVE
     QLTEILKVSQ SMKLIPSLHH SDVCRECYNV IQKFLEGDSR KNENYLARYL EFFQTQVQKG
     LDAEEVLVEI VQDNLKIVTR MAETRMTAMI DQFIATKDAR FLDFLSSLCV CSGRPIPSTQ
     DRLLTELVIR YGRELLYTTN LKKKGEKNEE VAVYYRPKDS SHARDIRSLK PNSTDPAIVD
     DYELLKGQLH MFGKLCKGNN KRTLDFLVIP RNRDGYVSFD QVFHCAQNTS IDPELRKCYV
     ELILVMFVDV DDNRPFLDQL CYSFKYEDLS PDPYGDTGDD EDTALTGVAN LHFKFLKLWF
     VKVITDYEHL CCNEENIEKN ELFAEILNVL GNLVRNGYYD SEEDIDELMK PLVDVLDGTT
     DKLNEGQNES SYNDKIRKED TKVNRAVFYV KRKALEVMEL FFRFKFYVKL QKFLNDFKML
     EGSGGRMLVG RKETRDGPPH DLRQLKVGID PARCHEWLQS SEMTKKVRLR LGSLCEGAIK
     GSFHDGHIPK LESVLLDLSE YDCDELVTAS LDLLTQMYFF EEQLFQKAQQ SQLLICQESI
     AHYDIVNELL PELRHLLLID PDQKDQDRIK VILTELSNLL IISDYNDEPN RSNQIMLDNF
     GILDDILSYI LSKGSEGSEA TVQQEVFQKC FHLLRRMTAE YKNVQERLFN RIEDLLSVKI
     PEALADLADL LTEMFTGGAE LALRVMESHV DRIFEIIVDC QNGTVQAHFM ITLEAMAKIE
     ELDINIKSTQ GMIVKNFCRY RNKFCHEVLG EGDKFAEDRL KILKRQEETP QLQLLLSVID
     LLAACAEGKH LFIESVCQNI LSIDELIKIV SEPLSPLRKK PFVRFLISVY MSSDRDQEDR
     SGSGVTLSHG GVIWTYLDHL AELLKDTAGA IHMINFEESK AGGRRQHLKT RKGIRPSSQF
     FLPPLKKVIP GVTDSKGVLV PGLLDYLIEG VIPFLHIYYC SYFSPASVNN EQQRDMEYET
     SIRIAQNMIT LRKELLKVSP SEHHVQMFRE IILSLHCHER IAREANIDAK VESMSVVSIR
     QQVDSKRKSY SRQKSVRIGP VQSISLREQL ILEEKEIIDS LSATQSPALP HRALMKYKDQ
     QKLNSTFKTF SRNYQLAYVG LNTAKEQIKS EISEKYSEEG EELPLGPNFQ CLVQLYIDRS
     GPTCKVSGKA EMLLKQLTAS QSRTEQLGER EQIIQDVLDV RCLQILRALI HNQIMRIDPE
     LKDRDPTIYR SKSNELIVPF QDAVQSYCGN AMLKIISLLS HTNESISKEA IALMKTMLFS
     GNENVQEGLA QSVKDTREET LFINLKEKLE NASVKYKETR DLQLILDGRK NLQSSNAEKK
     MSQSPSAQVA IAIEEPVVRY TPQPDDDATQ MDEALTCIFD QSEKPELLAY DTSWTNLVLE
     VIRYMCDGQN RTLQHYLREQ PDNFKTVNVV AEVTSLLHVY TSDLTVENLS QIDEIIQALV
     EMCVGNTPNQ RVIFEKQVNE PLNRLLGLSV VEAHQTCGQR DTDQCPKCKY LEDLVKVKGS
     VVQLLDAMLE NTSSQTQEIT EGIGSTIDVQ SLLDTMSFFC EFEEHPLMLL KEMNDDCERG
     MFRSYHILVS LMGSKAIEKI RKDKLQDDIK GAYEKCHENT RTIEIHFKDE ETSETTLARV
     HFPHNPDDSL REAVTELVRW SIDRDSMEDK QRALLDLMPA LKRDIIHQRN LNEKKVLKPL
     LMFPIFRYRL LMFLTVLLNL FVLFVYKVPT EATGVHLPMV PEWFIPYMLF ILGGFHLILS
     LWVFIEYFII NWPHFSLPSF VNKIHHYIAK KRNPEGTGSH LVTTTCLDVG IFGVKTLYMF
     VFLLSSILSL GLSGYFYCIC LLFIIANNDI LKRVLRAVTK NGISLIWVAV LGIIVLFIYA
     VISFAFLHQY FKITDDASLY CKSLLECMYS VLRYGLIDNI GLLIPLNATE DGNVESFSAQ
     FHIPRLIFDL SFFIIVITIG LNIVFGIIVD TFSELRGERS DIEKDQKSQC FVCDLPSHEF
     ERKAKGFNNH VKHDHNMWDY VYYSLYLDNI DTGDQNAIQK YVYQLIEKKQ TKFFPQQEAI
     CLAVEENTTD ELIESLIERV EYVVQHFKDK EQVKSVTAKK QKQKNWEEKF LGKTPSFYDD
     SQ
//
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