ID A0A1X7VD25_AMPQE Unreviewed; 810 AA.
AC A0A1X7VD25;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=SH3 domain-containing protein {ECO:0000259|PROSITE:PS50002};
GN Name=100641245 {ECO:0000313|EnsemblMetazoa:Aqu2.1.37422_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.37422_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.37422_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
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DR RefSeq; XP_003384974.1; XM_003384926.3.
DR AlphaFoldDB; A0A1X7VD25; -.
DR STRING; 400682.A0A1X7VD25; -.
DR EnsemblMetazoa; Aqu2.1.37422_001; Aqu2.1.37422_001; Aqu2.1.37422.
DR GeneID; 100641245; -.
DR KEGG; aqu:100641245; -.
DR eggNOG; KOG4035; Eukaryota.
DR eggNOG; KOG4225; Eukaryota.
DR InParanoid; A0A1X7VD25; -.
DR OrthoDB; 2915651at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR030125; SPIN90/Ldb17.
DR InterPro; IPR018556; SPIN90/Ldb17_LRD.
DR PANTHER; PTHR13357:SF1; NCK-INTERACTING PROTEIN WITH SH3 DOMAIN; 1.
DR PANTHER; PTHR13357; SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN; 1.
DR Pfam; PF00018; SH3_1; 2.
DR Pfam; PF09431; SPIN90_LRD; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..57
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 64..125
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 180..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..318
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..340
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 810 AA; 90129 MW; 9A7AA75EEB413FCC CRC64;
MATHKVLYDF AGEEKKMLKV KAGELVTVTS SGNNWSTVQK GSTSGLVPAS YLEAILPEEK
STHSKGSVFI AMFDYVGQAA YQIDIKKNDK LILRQVHTKD WYTMKNMSTG REGMVPASYV
KQEETTNNNG VEPQSAEAIK DVLLSIDRAI DKIHVDATTA GGFYTAEQRS TLQTLVAHRQ
SVVNSSESKE RTKSPNTMEA SVSTFSSPSP IPMETTSSPV PREMSSSPSP SHKNKHRRKA
PPPPQPTVEP LDLAGVQLRE KEGGAGANRP QSELIINVSR PAPPPPTRTV SLSKHTPSPS
HIVKESEKKE EEGKKEGGVM VIDMAAQKEE LRDSREQSVE CDDNSSQSSD GATLPVGGIS
PKTKQRLTSY LNRVGQPGNQ LETLSESEGF GKKLNLPTEF SNDTALELID VIRNRTGLSH
PKSALALEGV LGFLEEKVPE IAPVMDGLLA SLRASQAKEE DNSLSEDNED LKRLKHIFFE
MREARDDSQQ RGWAVRDDSE IISQYLEELL QILYDADPIV SKAAIQEDKY ENILVLISYY
QLEPRVQLRI LLLKVFGACC TLDQEVVSVM LQSVLPNELG HDIQINTNET QKVLFSSIVC
TMMFSTAEDV PLPVYDQWSA EFVKFLLDNI EDPPESDVND ELPDAFLNMI LSFNQHFEYP
STNIVMQVLK VFDNPRSFSE KLMLLVNRGE DPVSIVKPCC PDSLTKILLD LFSDPLTSGV
FYTTDLKVLI DIISRQLHDL APGDKSRSHY IELLQRLITN TQYTDHHHRR SDLTSCLKRI
LREEGEESIP DQGAIKKLLE TFPGLFDGSS
//
