ID A0A1X7VDH5_AMPQE Unreviewed; 892 AA.
AC A0A1X7VDH5;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.38360_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.38360_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU280815}; Single-
CC pass type I membrane protein {ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A1X7VDH5; -.
DR STRING; 400682.A0A1X7VDH5; -.
DR EnsemblMetazoa; Aqu2.1.38360_001; Aqu2.1.38360_001; Aqu2.1.38360.
DR eggNOG; KOG1217; Eukaryota.
DR InParanoid; A0A1X7VDH5; -.
DR OMA; AACEDKY; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 8.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 7.
DR Pfam; PF12661; hEGF; 1.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 8.
DR SUPFAM; SSF57196; EGF/Laminin; 8.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 9.
DR PROSITE; PS01186; EGF_2; 8.
DR PROSITE; PS50026; EGF_3; 8.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..892
FT /note="Delta-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010859286"
FT TRANSMEM 658..685
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 170..215
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 286..324
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 326..362
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 364..400
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 401..439
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 441..477
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 479..515
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 517..553
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 555..591
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 720..767
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 835..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 172..181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 314..323
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 352..361
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 390..399
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 429..438
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 467..476
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 505..514
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 543..552
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 581..590
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 892 AA; 96956 MW; E30CA6A5409E1B89 CRC64;
MNGWLLLLCL SLLSHLCTGR YTLLVKAVQY HNPDNQDWND GCCDWPCSNN CDLYFKFCIR
NKGLSASNIN NCWDSVQTYG DVSTNNYYFP NYGELYPGAR IWNDLTFNRN EPWPGSVQVL
VESLDADDNA DDLIDRNAFN LDLSPNGQWS NELYANGYYD RAQFRIRVRL FCQQNYYGSD
CNVYCVQRND DTNGHYTCGS DGAKICNNGY TNPSGNCLTP ICSSGCSSQN GYCNVPGECL
CNTGWTGTNC NECIPKSGCS TSHGYCNVAN ECLCETGYGG SLCTEDHDVC GHEAPCLRGG
TCTNIIPDGF RCSCPPGYNG SRCETEVNEC DPRPCQNGGT CFDRINDYYC ECVAGWTGTQ
CQTNIDDCQS SPCLNNGTCG DLVNGYQCSC VTGFIGPNCE GHHCHSTPCS NNGTCVQVTS
NDIGYTCVCQ PGYTGVNCTK EIDECSSAPC YNNATCIDAL ADYSCSCLPG FTGKDCQVNI
DECVRAQCSV HSICMDEVNE YQCICDIGYT GRYCDTKIDY CSPPPCLNNG TCSSYPGYYT
CNCQEGFNGT ECDNNIDDCV SDPCLNGGTC NDIIRGFTCT CPIGWTGLVC STVVSACDPN
PCPTDYICVD NTSATYGYNY YCEHCSEYDS CTFYGAPSPS PNPNSGAVTG NSNGGVGMLV
GVSVGGALLS CCFAMIIVGC CCYLCRKKTQ MKKFEIPIEG SHFSDNPTYI PPELLQSTTL
DRSASPQYGT SAQKLYGKGK KGRPLSPQKD GYELLDQSGD TTSSLRSTVR SGSLLLTGVY
DKLKHDNIYT ETDGPNNTGK GDFDEESFPP LKGTDTISPY DRLPFQEPTT PAYDSIGTSD
DQGANHYERI SSSPICTSPS LNTPYQDASI YATIPANENN YEPLPGSNDN NK
//
