ID A0A1X7VDL0_AMPQE Unreviewed; 771 AA.
AC A0A1X7VDL0;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Peptidase S8/S53 domain-containing protein {ECO:0000259|Pfam:PF00082};
GN Name=109580538 {ECO:0000313|EnsemblMetazoa:Aqu2.1.38116_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.38116_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.38116_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR RefSeq; XP_019849385.1; XM_019993826.1.
DR AlphaFoldDB; A0A1X7VDL0; -.
DR STRING; 400682.A0A1X7VDL0; -.
DR EnsemblMetazoa; Aqu2.1.38116_001; Aqu2.1.38116_001; Aqu2.1.38116.
DR GeneID; 109580538; -.
DR KEGG; aqu:109580538; -.
DR eggNOG; KOG1153; Eukaryota.
DR InParanoid; A0A1X7VDL0; -.
DR OrthoDB; 380531at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd04077; Peptidases_S8_PCSK9_ProteinaseK_like; 1.
DR Gene3D; 3.30.70.80; Peptidase S8 propeptide/proteinase inhibitor I9; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR034193; PCSK9_ProteinaseK-like.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..771
FT /note="Peptidase S8/S53 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010857469"
FT DOMAIN 133..376
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT ACT_SITE 142
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 180
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 340
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 771 AA; 83961 MW; 607E12FDD0172227 CRC64;
MNLGWSLVLL FLQFLSIAEP AKVIRAAPED TTTGNYIIAL SEGTSQERFR EIEEGVKNSG
SVIYTKVNGE YAKIISANLS EQTLEKFSEF EDIEFIEEET YATASSEVSW ALDRINQQNN
NKLDGYTNYN GDGQGVAIYI LDSGINYEHC EFGGRAMFSG YDPVDKIMGT NYKGRDCSGH
GTHTASIAAG ASSGVASKAK VYSVRVLDCD NRIPWSAVID GLNHVGEKIT EAKAGKNPSV
ILLPLSGPVS LGMDHTLEKL LNQNIPIVAA GGNDGGDACS KSPASTPGVI TVSASSNGDE
ASSTTNAGPC IDLFAPGVSV VGANHSCTGC ECKSIRSGTS VSSGLVAGVV SLYLQESPRL
TPSEVRDKLL NSCTRNTLHF ESLPQHLSGL TNNCLLYINT TIKMGDNLAL DPTNVVTTKT
VTVSIQASPT PETVCCQMVK NFESFELSLG NIVEREMYKA TQMLQSNITS LFTLNSTQSA
VAPSDKPDDN NVAVRKSLRQ KTYVHGTAVK SCKDLSHYGP LDSDYYPIIM QTGDEAMVYC
ELDKEIMGQR GFMRIANVNM SDPNTDCPDG LLLRTDGNLR TCQRSQHESG CSTTYFSSSG
VEYSRVCGRI KGYQWASPNA FYFSYQNKMK ILPMIDEAFV DGVILTYKEG ESRKHIWTFA
AATDEIDRSQ SYACPCTNTY SRASSAIPAF VGNDYFCETG SRSTFEYNTL YTEDPLWDGK
GCGEVSTCCD KGEWFCKDVP KTSSDIELRL CGNEPRENED TPIELIELFV Q
//
