ID A0A1X7VF86_AMPQE Unreviewed; 5861 AA.
AC A0A1X7VF86;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Staphylococcus aureus surface protein A {ECO:0008006|Google:ProtNLM};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.38404_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.38404_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR STRING; 400682.A0A1X7VF86; -.
DR EnsemblMetazoa; Aqu2.1.38404_001; Aqu2.1.38404_001; Aqu2.1.38404.
DR eggNOG; KOG1306; Eukaryota.
DR eggNOG; KOG1766; Eukaryota.
DR InParanoid; A0A1X7VF86; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.40.2030; -; 33.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR026919; ADGRV1.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR003609; Pan_app.
DR PANTHER; PTHR46682; ADHESION G-PROTEIN COUPLED RECEPTOR V1; 1.
DR PANTHER; PTHR46682:SF1; ADHESION G-PROTEIN COUPLED RECEPTOR V1; 1.
DR Pfam; PF03160; Calx-beta; 30.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF00024; PAN_1; 1.
DR SMART; SM00237; Calx_beta; 22.
DR SUPFAM; SSF141072; CalX-like; 36.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
DR PROSITE; PS50948; PAN; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..5861
FT /note="Staphylococcus aureus surface protein A"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012259639"
FT TRANSMEM 5410..5430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5439..5464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5470..5496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5508..5535
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5555..5583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5604..5625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5631..5652
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1323..1495
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2365..2442
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 5415..5653
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 5722..5846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5861 AA; 620042 MW; 510B88FFA645F4D4 CRC64;
MSVNLLHRLI TVALLVISLF FHTAECEGKI NGFISFGVTE LVADEDSNSG FTTVSIPFVR
EIGNQGNVLA TYEVINSSAS AQFLSLSNSV NFNGGQTEAN GFLVLINDAV PEVNQTYIVD
IIDARFGAEV GPTDRLYLTV RASDDPFGRI QFESSSLVRS AIEPLSGSTS TVSYDVIRGP
GLHGQVSINY EVTGGPNSAS LDVSLGQGQL IFEDGQNASN FTLSILPDNI PENNETFTVR
LYNPGGGAVV ADNDNEAQLI IISNDTPLRF ASSSIEVSEN VGTAQLTVYR GDIGGVSIGP
LDQVTTVQYS TLPTGTAIAG LDYTYTTGTL TFPSGSTSAT IGIPIINDTV PEGDETFTVA
LSNPSDDAVL HTPINVTVII DINDNAGGVV RFQSIAPQTI SEDNQTNATF IIQRDVSTLG
SLTISYSIKD SNNQLASSDF DPASGQITIP NGVDMSQLVI RAIDDTLPEE AESFTVSIDG
VQSGEGQLNT NETLRVALLH VSDSDDVYGI IGTSGTGSIA VNSDGNRVMS FTLTRSQGTT
GEVVVVYSIL YLPPGVTDPS SGMSGVAAAA TSTATFPNGH STVNAKLNLL TTGMLEEAAL
VYIQLVSAEL SDAGSLLTEP SSPRISTTSF TVNASVPLAA ANGHISFAPS SLMASVSEPD
NGFSLVSLTI QRNGEYGDAL VTWTASASSG SSFTTSDIGI NAAQVLIPNG ASSASFSISI
VADDVPELDE SFNVKLLSVA QVGQNIATTN ITAVVTILEN DEPGGTFSIA STSEGPFYIE
ESPLDSLSIQ IQRNGGDLTT EQVLYRIVPS GSDDFIGSSG LVTFSPSNRS MTVSIGPSLD
DIPEINETFT FEIYSTKDII RPPYNASITI LANDDWNGVF NFSSSSISST IDEPANPGSS
DPSLVSTANL TVIRNVASFG DATVHWEAAN LNTIDIEPTS GSVSFSDGVS EAVFQVSAQA
DNITEFDISH MIRLVSVSGG GRLDDSGTVA TVTVRQSDDP VSISSNDLVK SGEEGDVISI
NVTRGGRANG VAVVSFSVIY TSTSSSDVSI DPATSMITLM DGDRSGIISI TLLDDAVPEL
MEQLQIRLTS VTGDAVIASA NTLSTISINE SDDPNGLFQF NANSLSNTVT EGSSVDLTIE
RLKGTFGNVT VFWRALYNSN GVLTPVPPLT DISVTSDSVM FREGQTTASI TITILNDDIP
ELTEDYTIEI TNATTELAVV SIDNETASIT VPENDYPYGV FQLDSPGALW LGEDIPDADT
SNGTGVFNVS RTAGTFNDIQ VVWEVRPIPA PSLPTSFTDL LLVGSRGSGV SIATPRPSTG
TTALSFTGGS SSLVTVPSAL TPHVANNMSI SVWFIFNGSV NGVLVGSANG NTVYYGLALV
SDTNQYIVRL LYLPSTLNSG SETVEVSVPS SSLPMNEWHL LVLSVSGTSA SFYIDGTLIN
TRTLSAGLST ASSDGVVTAG GLTGSQYFVG NLQDVRIYET SLDQQQVSDI YSNPAADHFQ
YISGVVTVHD RQDRNTFSVQ TKDDSIPEPT TNFTLSLIAV SGEAQLSTTN LATTITVLKS
DYSNGLFGLS SLTPFNNVEG ATADIIVTRS RSSIGTVTVA WEIRNLADGS LADDDFEESS
GTIVFSSGIN ESYFTVQSTN ESVPELDESF SISLTAATVD DTYPSSTPTS GASLSPNTTV
NVTILSNDYP YGVFQFEASP PPVAGVIPSA DAVVTTAITE EIGSVVVYIV RAQGTVGTAR
VDYTTNDGTA LSGGVSPDYV PTGGTLMFAD GERIKNISIA ITNDQTPELA KYFYVNLSNP
IGNNDGTPIL GTGSDIVITI SPSDDAYGVF SFNDESLSQI VSEDQSGSTL VSYVVERGNK
GRLGTVTVYW EVVNGGNDVS QSNGSVVFGP GVPTSVFFFT ITNDMNPELH ENFTVRLVRV
SDGRISDTGN AVAILTIRAS DRPYGVFTFS PSFSPLSITE DAGTINVIIL REFGMEGTVE
VYYTNLNDST EEGYAIAGFD YTPVSGSVVF TPNQTMASFS VSIIDDTLPE IPETFYIILV
NATLLDDDGI HLGTDALPLI SSANASILIE ENDNPRGIFS FTSSSFTAEE GTTDSITVTR
TAGTYGEVTI SWFITLINAS SSDVNAVQGT DTIPDGVSLA PLSITVIDDA LPEFTESFFV
ALTTISGGAD LGLPILATVT IPTSDDPYGA FVFAESSRSV SVPEPDSGMS SITINVTREG
GTLGLAFVDY NITSASGEPV SSDLTYDSIS NLYFANGVRE RSLTVRILSD DIPEITEVFY
VNLFGVTGGG RVGAFGVAEI RILANDKPYG SAVYLRDSEI LTMENDENAT TINIPVYRTG
GLFDDVSVVY SIRSATPSSL DRYQSPSTGI SPPTSVLLLQ SSDYVTSDRL NECGVKCVED
YTVCQSFAYD SSTSLCQLYR STVGVSGSVT RSNTVQYYEA IPGQLELLAR HIASASQDFE
YLFNANVTIP AGRNSTHSDS IEVSINSDTL PELRENLTVS LMSVSVSGVN DDSLLPVIGN
YSDTIISIAE NDDPYGLFSI SISQLSTVQV HEPSGTGTLP VTLTITRSAG TNGPANVSLI
VNGVTATLNS DFSINQTLVQ FADGESSKTV VVHILGDAEP EADESLTISL SNPTGGASIT
GEELTIVILT NDNAAGTVRL ASDSRAATIS EGGTIRLTVE RSVSQLGRLL VNWTITGSLN
STNNNNNNNQ FNGNFTGNND TFFINGTDIG GAGPESQFQT ASSFIIFEEG VTSVDIVTTV
IDDNIPEVQE PYYLTLVATR ILSSGVGEAI LDANGNVAII TIRASDDPYG VVEILSSSQP
IEENESDQPT VTVLRNFGSL GRIVITYQAV SYQLSGQMSA TPGDDFDNST MTVIMEENEA
SATIIIPIIN DDIPELSEVF AIQLLSAYLE SDPSVSVPLN PNSTLALITI NPNDNPSGMF
QFTMNELTVS EDAGIIDIEV VRTGGLFGSV TVMFQTVGDL NDFTLINMSI VFADGVSSEV
AKLNIINDNM PELDESFDVQ IFSVSNEGLT GDNNSLTVTI SANDDPNGRF GFSPSSLSVS
VEEAGAVVND DNIAELTVIR EGGTFGTVTV PYMIETAGAN DLSPTTGLLV FQEHETQQVI
RITAVADTEP EIDETYSIFL ETPISPIANG SSLIDDESVA MITIPANQNP YGTFELYAPN
SLSSLSVEED VGTVRLELRR TTPSFNDIIV HIATLSDSSM MTNDTNGTID YTPVSSPIVY
GANVSMIELP LGILNDDIPE LDETLIVQLV NVSGGAMVGD NREVTITVLT NDDAYGAVGF
AESSLSEILS EPEFGQSTVN LVVERTGGLL GNITVAWSLS GDHSSGEVTP ANGTLTFNEG
QESDMIQLTV SSDETPEISE LTNVVLTSFI DNGVPEGGDQ TKGARIIESR STAVITVTAN
DNPFGSVSWA GAGISIAATE SNSGSNPVTL TILRVSGNHG DIEVTYRTTV DDFAIPGQGA
VAGADYANVS EGLATIRDRE TSTTINILIL PDNIPEIEET FAVELVSVRL LNDSLAVGAP
PNSPNIQQPA VARVSIAEND FPQGLMNIDP GPFTVSESVD TTCIPVYRSG GMFSTVGASY
SFTDGSATGG SDFDNTEGTI SIGPQVSQGC LNVTITNDNT PESEESFTVT LFNPTGGVTL
GENLTSTIII SKNDDVNGVF SFSSGSLVML LPEGTSGTFT IDRAAGSVGE NIVYWSLSSS
GSDDMNQTNG SVVFTDSQTS GTFELQALED GVPELYEVHS VTLTSIVGEG RLSHPLTASI
AIPANDNPSG VIAFAEYTYD TVIIEEGGSA TISVLRTAGL FGSVSVQWQI TPSDSTAFVL
TSGSVFFGDG ANVANFTLST IQDTSPEVAK IFTLSLVAAG DADINSSSSD INIIIPSSDN
VHGSIGFSPL TVSTSESVDS IDITVLRSGG LEGDLLINFT VSDIQAVSPD DYQINATYVM
IPDGSNTAII TAAIVDDSEP EIDESFSVTL TAVTLLNYNN GGRDFTYPGD DSLIDSLPTI
SDSSDTFQAT IAANDDAFGV ISLTTNSYQV EEGTTLLVNV ERSGGTFGTL SLQFTVQSVS
ALGNGIDYSA PTSPINILPG QALLQLTIPI IDDINPELQE SFTVTIDSVE GGASLGTIRT
ATVIILPSDN PNGRVRFTDS DISGRVVANP VNSPSDVMLE VLRLDGSIGS IDVTWEVTGP
SPGFERDDIL QSTLQGVLTF GDQQTNNFIT VTVLTNNGPE PEENFTITLT AATKGVAIDE
DGQTALLTVS QKGIPFGVIG FYGTSLSTSN TPEGVNLTLP LVREQGTFGT SEVFFVVSGP
SPLLDLSPVT GSVVFEEGDV YVPIDIFIIS DNIPELLETY TVTLTGINGR AVLNSNTLTS
TFNIIANDSP YGTFGITDLS LQLAYAGQDM IRRLSFTISR QFGLQGSVDV TVGITYTEEP
NAGYFPSSIS RSFINGQDSI SVTIDSTATA FLAAGSILNV SVATVTLTSQ AGDSDVLPEI
SSFTGIILHN ISENVSNPSV GFALDDVNAT VIDGQVSNNV PITIQRHGLV GNIQVTWGTG
LLIEGTTNGS LTPATGSFIM SADTSQVTVN FTAIPTDPPT QSEVFAIRLA VETRSPPFVA
RVRTGADVSI IEPWGVIKLT YDSYSALEGQ IVNVSVSRLY GSTGAIEVSG ISKSPSVIPN
NALAADPVID YPLATLSTIL NDKQTAGNIQ IILPFNTQVN PLKVFDFSLT GLRTVNFDGP
FTTPRLATPI QNASVTIIDA QGGAGVFEFV SSSTTIHEDG SPLVQALINR TSGTAGSVSV
QLSIVETRAD GTTPANQIAS AAEGDYDLSS LATMATFANG ETLKSVTVQV LNDNVPELEE
YFTILLQNPQ GGKAIINPAK STFEVGIYAN DNQGGVFSIV TTSLSLDEDT QPEGTITVSR
TGGLFERITI DWQTYYSDGG VHPVALGDLL VRDSGNVTFS PGQSLANITL ALSPNKVPAS
GETFSLRISS STVGITFAVR VATITAAPSR FSVYQFSVNS RSVVATDLTQ VLMIQRLQGL
KLSSQVSYST VESADPITVG EVTFLPALAS VHFTSVTSAS VLFPIDVGNA TIQLNIISAD
VIPRAFYVTL SVPTDSSSVL QNERAVVVIN HPGTESDLYT DYLTAYHSTT PSQLSSAATD
ILNKLSNGAV SGRNVSLSTT MKLTIEEIIS TVTESGISYP ASLQSTMASI FNAIIGSGTY
DEQFRYALTL KSFARSLVTG RPCDGQSVSI STVSLQINSG RYTPSLLSGM TFTSGVNDYI
RLSSSALPIT SECVDAHFIE YTDASLYKLP LLGMKVMVLS LDNPSVPTLP NPVTYRVYSP
SGTIYPSDQD CLVWSYPTDD SGTGSWDQST CTLAEASILE RDYVECQCQL VGDYAVGIPP
SYGWPLPGPI SSGFVVLVMI LIIALHTIYF KRIKLGTRIL IFVCLSIALF QIILLIDMVV
APTVSTNGCI ALGLLLQLTV LAQFVWMFVL VMSLWMNLMG LTDGNEPLII YIFVGWGIAI
AIVIATILIS LFGAAQSWSD IYGRVGGLCF MPSPAIAGVS SALPIILVLL IGVGILSHSC
FYWSKWEDFK SLYKDTFNKR EIPLLLTFMA IIVINIVFGA LHLYLQQIYL FFLFFAFNII
EGIYALIVYL FVSWHTLTWK HKHYPIKEDV EPLTIPEEPE FMGEHYPSMY GSQLSLLPRT
STHNKLSSHG QIGSQEHIMM KRLSPPPTTA TPSVHSSVKP SHTSKKKKKQ KQKQQEKRAD
SSLPPSLPPS PPPIEEVQEK DGDSDSGESG SYAIARAGDS DGGESGSHMD NLMFALKTGI
SYSQDEDSQP PIEGFARRGK QPAAATEQYR LRRISIADTH L
//
