GenomeNet

Database: UniProt
Entry: A0A1X7VHQ1_AMPQE
LinkDB: A0A1X7VHQ1_AMPQE
Original site: A0A1X7VHQ1_AMPQE 
ID   A0A1X7VHQ1_AMPQE        Unreviewed;       774 AA.
AC   A0A1X7VHQ1;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Kazal-like domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Amphimedon queenslandica (Sponge).
OC   Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC   Haplosclerida; Niphatidae; Amphimedon.
OX   NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.39846_001, ECO:0000313|Proteomes:UP000007879};
RN   [1] {ECO:0000313|Proteomes:UP000007879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20686567; DOI=10.1038/nature09201;
RA   Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA   Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA   Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA   Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA   Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA   Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT   "The Amphimedon queenslandica genome and the evolution of animal
RT   complexity.";
RL   Nature 466:720-726(2010).
RN   [2] {ECO:0000313|Proteomes:UP000007879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA   Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA   Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA   Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA   Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA   Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT   "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT   evolution of animal complexity.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.39846_001}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2017) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   STRING; 400682.A0A1X7VHQ1; -.
DR   EnsemblMetazoa; Aqu2.1.39846_001; Aqu2.1.39846_001; Aqu2.1.39846.
DR   InParanoid; A0A1X7VHQ1; -.
DR   Proteomes; UP000007879; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:InterPro.
DR   CDD; cd00104; KAZAL_FS; 2.
DR   Gene3D; 3.30.60.30; -; 2.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   InterPro; IPR039016; RECK.
DR   InterPro; IPR000716; Thyroglobulin_1.
DR   PANTHER; PTHR13487:SF3; REVERSION-INDUCING CYSTEINE-RICH PROTEIN WITH KAZAL MOTIFS; 1.
DR   PANTHER; PTHR13487; SERINE PROTEASE INHIBITOR; 1.
DR   Pfam; PF00050; Kazal_1; 1.
DR   Pfam; PF07648; Kazal_2; 2.
DR   SMART; SM00280; KAZAL; 3.
DR   SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 2.
DR   PROSITE; PS51465; KAZAL_2; 3.
DR   PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..774
FT                   /note="Kazal-like domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5013367424"
FT   TRANSMEM        754..773
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          187..268
FT                   /note="Thyroglobulin type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS51162"
FT   DOMAIN          365..414
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51465"
FT   DOMAIN          498..529
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51465"
FT   DOMAIN          537..568
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51465"
FT   REGION          77..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          464..497
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          732..752
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..125
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        464..489
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   774 AA;  85017 MW;  D74959B0F12F2821 CRC64;
     MPKAAFALAF FLTVIALQLA DANRFGNVRV VSCERARRFY EYISXTTGPN APTRCGSDEE
     YVRRGYGWGT CRPKLSGNDT CVREEEDDDD DDDVYDDDDD DDDDDDDDDD DDDDDDDDDD
     FVSDDIPVAQ LELASSMEED MMEKDEDDRV SRIVTGSSSR RASRKINRYI NQCSDGYYCR
     KVRDDSRGRC EQQNTDGVCY RNSNNASGEC DSNGYYKPRY CRVVTVNNRR RIICVCVIPS
     NGTRLADTRT TFEDTGNEEE NENRKPKCSE RVYGTCRVTR GGRRFSMKHG ERDTNPCMCR
     TCVCYFGTLY CRTRRNCRRC DSTKTCTLPN DTVIRHGQSA RVDCNRCSCR YGNLYCTDRD
     CNTTATTDTN CTRCRSEGVS RVCGPNGKTY INSCTAIYCA GIASVDLIDG PCPRTNPCIR
     FPCDPGQVCL KRGGVSCLAR NTGCRPDTLR HCINVTDLSC TNETAVSDDD DDDDDDDDSD
     TDGDGIGNGD VDPDDTSICG TDGNTYASIC HMVQSTVNVT ILHAGHCNAL RCKGGRVCGT
     DGVTYENICE LRTQSNNARF DYRGACVDDS DETPDGVCER VISSGRCRFN TSNCPCLVRP
     TVGCCPVCGG AILALLDIEG ISNASSLDPD LETLDGYVRQ IVSDELFLNV TAGRCSVESS
     LTTAGNIELA ISSMSNRSND RCYCHRVATN ITIAINRSVE EQSRKRRQAT TNTDTSLSPS
     YQYILGASEA QLETSTGGPG TEGTGTTATP TSSGVTATFA FMTVLLLTVL AIVI
//
DBGET integrated database retrieval system