ID A0A1X7VHQ1_AMPQE Unreviewed; 774 AA.
AC A0A1X7VHQ1;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Kazal-like domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.39846_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.39846_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 400682.A0A1X7VHQ1; -.
DR EnsemblMetazoa; Aqu2.1.39846_001; Aqu2.1.39846_001; Aqu2.1.39846.
DR InParanoid; A0A1X7VHQ1; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd00104; KAZAL_FS; 2.
DR Gene3D; 3.30.60.30; -; 2.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR039016; RECK.
DR InterPro; IPR000716; Thyroglobulin_1.
DR PANTHER; PTHR13487:SF3; REVERSION-INDUCING CYSTEINE-RICH PROTEIN WITH KAZAL MOTIFS; 1.
DR PANTHER; PTHR13487; SERINE PROTEASE INHIBITOR; 1.
DR Pfam; PF00050; Kazal_1; 1.
DR Pfam; PF07648; Kazal_2; 2.
DR SMART; SM00280; KAZAL; 3.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 2.
DR PROSITE; PS51465; KAZAL_2; 3.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..774
FT /note="Kazal-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013367424"
FT TRANSMEM 754..773
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 187..268
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 365..414
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 498..529
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 537..568
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT REGION 77..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 732..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..125
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..489
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 774 AA; 85017 MW; D74959B0F12F2821 CRC64;
MPKAAFALAF FLTVIALQLA DANRFGNVRV VSCERARRFY EYISXTTGPN APTRCGSDEE
YVRRGYGWGT CRPKLSGNDT CVREEEDDDD DDDVYDDDDD DDDDDDDDDD DDDDDDDDDD
FVSDDIPVAQ LELASSMEED MMEKDEDDRV SRIVTGSSSR RASRKINRYI NQCSDGYYCR
KVRDDSRGRC EQQNTDGVCY RNSNNASGEC DSNGYYKPRY CRVVTVNNRR RIICVCVIPS
NGTRLADTRT TFEDTGNEEE NENRKPKCSE RVYGTCRVTR GGRRFSMKHG ERDTNPCMCR
TCVCYFGTLY CRTRRNCRRC DSTKTCTLPN DTVIRHGQSA RVDCNRCSCR YGNLYCTDRD
CNTTATTDTN CTRCRSEGVS RVCGPNGKTY INSCTAIYCA GIASVDLIDG PCPRTNPCIR
FPCDPGQVCL KRGGVSCLAR NTGCRPDTLR HCINVTDLSC TNETAVSDDD DDDDDDDDSD
TDGDGIGNGD VDPDDTSICG TDGNTYASIC HMVQSTVNVT ILHAGHCNAL RCKGGRVCGT
DGVTYENICE LRTQSNNARF DYRGACVDDS DETPDGVCER VISSGRCRFN TSNCPCLVRP
TVGCCPVCGG AILALLDIEG ISNASSLDPD LETLDGYVRQ IVSDELFLNV TAGRCSVESS
LTTAGNIELA ISSMSNRSND RCYCHRVATN ITIAINRSVE EQSRKRRQAT TNTDTSLSPS
YQYILGASEA QLETSTGGPG TEGTGTTATP TSSGVTATFA FMTVLLLTVL AIVI
//