ID A0A1X7VKN6_AMPQE Unreviewed; 1043 AA.
AC A0A1X7VKN6;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Kinesin motor domain-containing protein {ECO:0000259|PROSITE:PS50067};
GN Name=100635765 {ECO:0000313|EnsemblMetazoa:Aqu2.1.40607_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.40607_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.40607_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. KIN-5/BimC subfamily.
CC {ECO:0000256|ARBA:ARBA00034704}.
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DR RefSeq; XP_003383917.1; XM_003383869.2.
DR AlphaFoldDB; A0A1X7VKN6; -.
DR STRING; 400682.A0A1X7VKN6; -.
DR EnsemblMetazoa; Aqu2.1.40607_001; Aqu2.1.40607_001; Aqu2.1.40607.
DR GeneID; 100635765; -.
DR KEGG; aqu:100635765; -.
DR eggNOG; KOG0243; Eukaryota.
DR InParanoid; A0A1X7VKN6; -.
DR OrthoDB; 536293at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0007051; P:spindle organization; IEA:UniProt.
DR CDD; cd01364; KISc_BimC_Eg5; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR047149; KIF11-like.
DR InterPro; IPR047241; KIF11-like_kin_motor_dom.
DR InterPro; IPR025901; Kinesin-assoc_MT-bd_dom.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47970; KINESIN-LIKE PROTEIN KIF11; 1.
DR PANTHER; PTHR47970:SF12; KINESIN-LIKE PROTEIN KIF11; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF13931; Microtub_bind; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000007879}.
FT DOMAIN 18..357
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 985..1043
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 417..462
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 806..866
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 988..1017
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 104..111
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1043 AA; 117619 MW; 4F12B595CF73B408 CRC64;
MERSGGKPRK TLPPQEKNIQ VVVRCRPRNN SEKKSGSPQV IDANTRKGEI VVHQELHEKA
ITKTFSFDRV YGPESTQIEV YHGVVEPIIA EVLTGYNCTV FAYGQTGTGK TYTMEGERSP
QGALSWEEDP LAGIIPRSLH QLFDQLECQE SEFSVRISFL ELYNEELFDL LSNGNEQVKL
RIFDDSARKG GVLVQGLEEI TVHSKNEVYA ILERGSKRRQ TAATLMNASS SRSHTVFSVT
VHIKENSLDG EELLKTGKLN LVDLAGSENI GRSGALDKRA KEAGSINQSL LTLGRCITAL
VEKCPHIPYR ESKLTRILQD SLGGRTRTSI IATISPALFC LEETISTLDY AHRAKNITNR
PEINQKLTKR ALIREYTGEI DKLKKDLLAA REKNGIFLSP ENYLGMETKI KTQGEFIIEL
EEKIRSCQEE IKKLETMFGD IKEELHEKEA ELAVRCQELE HTQFSLVETK KNLSQVKREK
DETSYLMTEH IKTEEVLHGQ AKQLMSTIEN AVDDVEGLHS KLDRKSTIET TNKQTAAQFN
ESFGKETSAL RDNLHTLKTH QLEFTGSLME SIRGWSVSHG QHVRHIQELI GTIQSAVGTS
SQHHTTVLKE RLATNTQRVG EMDTSHFEKS FNKACNVLLV TDLMPLISQL NEAISIHATQ
QQSVLDTVKQ KVLDYNDTVC QFESSQSEKL REMESAIEKN KEEQSNKLDS ISLKMDSTLS
EQDLLQQQMF DELSKTVSRW ISTAKQSMTT QQQTHNNELK EGLKECKVEH QEISSSLHQS
VNEIRSNVCQ FKAASTDVTS NAVQQLDQLL AESKSCQAKE KELLDKTQSG IDTGLKSLKQ
ISTDFNESLR SQRDDLVNLL EEQTNVSTAT ITSQCGNVMD IANQTQSSMS HTFNENTLKM
SQEWQDRLAG NRQDFERSMT ERDSDVSKLK EVVDQFMSID LKEDIPTGMT PQRRQFTYPR
VLSQTKPHSD LLHEYRDKLA DLAEVSESPD QSYDTVSHDT STCSSASSTC SFKDAEKSQE
NQAMKKKKMK SKSKGQKPLQ AVN
//
