ID A0A1X7VMM0_AMPQE Unreviewed; 876 AA.
AC A0A1X7VMM0;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN Name=100641327 {ECO:0000313|EnsemblMetazoa:Aqu2.1.41641_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.41641_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.41641_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_003383458.2; XM_003383410.2.
DR AlphaFoldDB; A0A1X7VMM0; -.
DR STRING; 400682.A0A1X7VMM0; -.
DR EnsemblMetazoa; Aqu2.1.41641_001; Aqu2.1.41641_001; Aqu2.1.41641.
DR GeneID; 100641327; -.
DR eggNOG; KOG1217; Eukaryota.
DR InParanoid; A0A1X7VMM0; -.
DR OrthoDB; 5487at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 4.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR24042; NEL HOMOLOG; 1.
DR PANTHER; PTHR24042:SF5; PROTEIN KINASE C-BINDING PROTEIN NELL1-LIKE PROTEIN; 1.
DR Pfam; PF07645; EGF_CA; 4.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..876
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010873659"
FT DOMAIN 477..513
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 523..565
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 566..596
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 598..636
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 641..676
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 568..578
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 586..595
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 876 AA; 94984 MW; 9DAC867AF305A994 CRC64;
MANCSLLLSL LTLALLYHGA STSQEDACQS TFDFNVFHYY TSVPHRQKLH PILMKSGPQL
SGRDPNEPSF EFTGGSGLIV NDTKLINKMS SLLCSANELA VYSSVFFKND QSGGTSLELY
HVNETFLGLS VCRISNVIHV AYRHGSRLRF ETFPFKFSSG KWYKLAVLFS GNMLTVFVNC
SLLEKRIVPM PDYCPSPDKL SLITGSGCLT KELSPCTTGF TGSLQSVELN IGKSASVKGC
TGLNKSAQCP VCGSFLTLLK NHYKLQETLS SVQSSLDNCT KTLNAINCSS STHSSTSCII
HKKNYPDGAF VRNSTGHICY CRDGVAHCIA NSSISMVAEE SQQTRTLTPP TSAPAATKTC
LATDTFGPTV TLAPGESKYF PLPSENKCGI ITCKSLSSKF IFNSVEKIDC DSNVPSSNCN
NDDESKQKLA VCCGRCTVCE SVARCPMNSS CVPKGVDYDC ECNKGFEMTN SNTSCTDINE
CSTNTHNCPS DASCINSVGS FTCKCPAGFE LSEEGNNTLK CIDIDECNVV GMASCDANSN
CMNTRGSYNC QCKEGYTKNE NGRCIAFCER KCLNGGECIA PNTCRCVPGF NGQQCQNDIN
ECLGQHECTH NNSKCINTHG GYFCNCKEGY QWKESTRECI DVNECASGIH YCPEGSRCLN
TFGGYQCPCK GGSQCTGYCK NDKDYIAEGA SISLGVDQCD SCVCKENSLM CKRKECKCDD
RDVSKVCCPH CFEKDVCHID KVAVDVDDYL VDPQNRCIRK KCVKDSHGRL SISTTDLSAS
CTPVSGCPAN HTYIPEGGCC PVCQLPSCTA TNRPPAVTLN CETCTCDGSS WSCTKTTECP
SHQQLGCSKD ELIKLPNQCC PVCHQEIIDK LTCSST
//