ID A0A1X7VP90_AMPQE Unreviewed; 1840 AA.
AC A0A1X7VP90;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=BRCT domain-containing protein {ECO:0000259|PROSITE:PS50172};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.41704_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.41704_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR STRING; 400682.A0A1X7VP90; -.
DR EnsemblMetazoa; Aqu2.1.41704_001; Aqu2.1.41704_001; Aqu2.1.41704.
DR eggNOG; KOG3548; Eukaryota.
DR InParanoid; A0A1X7VP90; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR CDD; cd17745; BRCT_p53bp1_rpt1; 1.
DR CDD; cd17724; BRCT_p53bp1_rpt2; 1.
DR CDD; cd04508; Tudor_SF; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR047249; BRCT_p53bp1-like_rpt1.
DR InterPro; IPR047250; BRCT_p53bp1-like_rpt2.
DR InterPro; IPR047252; TP53BP1-like.
DR InterPro; IPR002999; Tudor.
DR PANTHER; PTHR15321:SF3; TP53-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR15321; TUMOR SUPPRESSOR P53-BINDING PROTEIN 1; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF18428; BRCT_3; 1.
DR SMART; SM00292; BRCT; 2.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50172; BRCT; 2.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879}.
FT DOMAIN 1637..1734
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 1751..1839
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 23..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 586..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 934..1080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1127..1238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1390..1415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1434..1471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..155
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..328
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..625
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..704
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 862..882
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..976
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1011..1047
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1066..1080
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1127..1150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1162..1177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1195..1216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1840 AA; 200596 MW; DC6FB599F53D91F9 CRC64;
MSEAWIPIMA GEDRDERDRL RFTLRRLRQE DEEEEEQPEL PQRNDTGERE ADGNIEGAPR
TLLLFRLSQS MDQMDNMFEL TPTTDTPSSS FNNNPPLSSA STSNNALLPS LPSSSNSASR
GHGPIFDIAS FMEESRQRQE ARDREETEAA EENTLRLRTV RQTMVVPGES TSSPSSDQLS
EEEWSSSTRR RRRRRSATGS DDQAVSDVSH PLSVTHSHTL REAALDCPST TDSEPDQLLP
GTKYESTKYQ RVPTVKKHVL EKQRRDLEQT QEYVEKISSK TKLKATPPSS QDSKTSGSSD
YIASAQSGLS CSLESTSSTT VQETDEGSQD ADCTLDRSHG LFKFKGRIVT KFDHNTDNRE
PMTDAEIIDS VATIAEEGTQ DLFSVNDANN DSQYERTNTV PRWMLQQQKE QESEQTDLEE
LTEETQRGEK RSRLDSSPSS GTDPTLSPTM KPPTKRPAGR IQSDSSCNSN EVSLLIINVI
IMSEVIINVI XXXXVKIAVT TTSIKSPTSS IELSSSYSQS ITSTLQSVSS GYMPSGSSLT
SSSDIQSSPS LSSPPVDLPC VGPVTDSEGD ITDLNFIIMP KGLLDFDTTA TSSNSNNNNN
DKKTSTTTTT TTTNTNSSSS NSSSGGKEDK AKDKRGEREG ERDDNGGRRG GDSNERGDRS
GQDKEQTSDQ TDGENQETKI VEESELQGND DRGSSGEELR ELPSSNMEDT ATTANDATNE
QLKLLKGRAD NSIITIDDTN NDKDESELTE SLTNDSCIVI QKESLIDSLQ PSLTIDSPNL
PFSPEREEKT HSIETGSVLS PALLANDSRI DSAHTLEGNC TDTSAGTQNS FRLHVSPSQS
AMEPDDDTAV FVIGSSTEST KGDVLSHSPL KLSSDSIPST TPPVPSHSIP STTPPVPVYE
SLQLSNTEVS STNSMILSTS PISNVIITPQ ADVSQTNSSG TFDFRLPDSD MLLPTDGTSE
AHVEDMETDT GDNDQSTKEQ TRSNGVAETK GRSPGKCLSL RRRRSMSSGE NTPKKLKQDQ
STAKATDPLQ SDTTIDSTTN GVRNGQGNKE IDGSGKGETR RSDRTGSTLA SKSSATIRPT
ASLRTTATGF ILGLTEEEGD NCDTFDDSSH FELPPITALN SESEVSPSDI SFTKTDGVSA
TTNTGPSLPL AVPSSLFAGL QHTRRKDTRR TDPYEFQEED SNTDTPLFMP LRRRQEPQTS
LNNAMESENP LPLSTIEDDT EATAESEKEG EAATVTSTPV RRENIVVSGS TSQAQTQELV
NASTPLTTPS NVSTIASSAM SSLHFVSPIT CLTPQGVKDI FSSNPFSPLI RLRHSTTVIT
SHVFIRDEII DRNTEKVIQT LDHVVGPSEE RKVSIEATPL SSAHVLNPIP AQQLSSSSYV
STPGIPCPAS IQSTSSISHD PMNPPSMNSS VYNQPLRHSI SPLSATASSH VVNSSCTENH
LTPSTSVISS EARSQSTTPT GRSRAYSPLR SQSLDLDSLP STLQCTTSSV VKNKSHQSGF
KLVENQKVIA RWKDGKWYAA TIVEVSPIKA YLHFYDGDYS SVSVQHILPL ACIPQGVKVS
SADTDISGSL LDFSIPDSTF RMKLSNDTIM KCSLEDLVMT ADTAEMTLQL LNTQSKQVKK
RKKSVSKRPQ KESLSHKESV LFSGMIFLVT DQRSSQPTGR EEIEQILRDR GGYIMDEYKP
NLVIDNRTFC LSNTYCRTLK YLTAIAVSLP CVSYNWIMEC VKQGKIVSWE KDFSLLAGVS
PSTKQQIKWK SHATGFLKVN VFLSGSRTFK EIWQKVISCG GGHVISKLPR KSSKESQFTI
VSESSSIPVS LKDFLVVSPE WLVECLLAGK VVSPEPFKRS
//
