ID A0A1X7VR39_AMPQE Unreviewed; 1183 AA.
AC A0A1X7VR39;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=MIF4G domain-containing protein {ECO:0000259|SMART:SM00543};
GN Name=105313701 {ECO:0000313|EnsemblMetazoa:Aqu2.1.42542_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.42542_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.42542_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_011405646.2; XM_011407344.2.
DR AlphaFoldDB; A0A1X7VR39; -.
DR STRING; 400682.A0A1X7VR39; -.
DR EnsemblMetazoa; Aqu2.1.42542_001; Aqu2.1.42542_001; Aqu2.1.42542.
DR GeneID; 105313701; -.
DR KEGG; aqu:105313701; -.
DR eggNOG; KOG2051; Eukaryota.
DR InParanoid; A0A1X7VR39; -.
DR OrthoDB; 276824at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR Gene3D; 1.25.40.180; -; 3.
DR Gene3D; 4.10.80.160; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR039762; Nmd2/UPF2.
DR InterPro; IPR007193; Upf2/Nmd2_C.
DR PANTHER; PTHR12839; NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2; 1.
DR PANTHER; PTHR12839:SF7; REGULATOR OF NONSENSE TRANSCRIPTS 2; 1.
DR Pfam; PF02854; MIF4G; 3.
DR Pfam; PF04050; Upf2; 1.
DR SMART; SM00543; MIF4G; 3.
DR SUPFAM; SSF48371; ARM repeat; 3.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879}.
FT DOMAIN 67..268
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT DOMAIN 509..697
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT DOMAIN 712..917
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 939..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1120..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..479
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 971..992
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1120..1134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1135..1152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1160..1183
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1183 AA; 134429 MW; 5A07E26727696CA6 CRC64;
MASGDTSVKE EDEEEPRVSE EEREEALKLL AELETKAEQK RDIREKNLHA SDNRPDEDEL
RRGDGSIKKN TAFSKKLKDL SEAKRESLVA EFKKLNLTKY LTEAATSIAE AKMKLSDVSC
AVHICSLIHC RYDEFSDHLL DLLQKIYSGK IEKSNSDEKN ANSTKYRLGL RLTGELLIAG
VIDQDIGVAL LMEMLTEVVT ADKKEPDHTY LPVIVGFSRH LAEDIAGFMP RKNKLLLTKY
GLESPQTRFL SDDQQGMFRS LLLGYYDTVK RYLISQHKEM HRRARRNIQI MQSKGELSSE
REEENEKAQK NYEKLVTSIS TLSDVLDQDF PDLPEDTVLP ETFQSSSIDL QLPSFSSDNE
FSTSSLWEDE EQRSFYEDIT DIKPHIPAIL FEGIDSKRKG NNVSESSDVS EGDTGEGGAG
GIGGEGEGEG GEGEGECEGG EEGDEKARQI ILEELIKETE EQSSDDQEEY EEEGGATGDD
GEDSVSHVTI GPVDESSGSG LSTDVSKFDE LALKLPNMMN KKFVDEFAVE FCLINSKINR
VKLAKVLFNV DKNRMDLIPF YSRLLVTINP CLPDVPELVM DMLNRDFKFQ LRKKDQIHVY
TKIKNARYIA ELTKFGLFPK PEAMRCITRT LQDFTHHNVE LACTLIEHCG RYLLRSKESH
LRAGAIMEIL VRKKSVHHLD GRQKSMVEDA LYAANPPDVS ATTVIVRPPL QAYILKLLYK
DLNKRTVEKV LKQFRKLPWN DPEVFNYAVV ALSEIWRVKF SNVHCVADIL SGLKIYQNKA
VVWIIDATLE DIRLGLETNL PHMNQRRMAV IKFLGELYTY QLIEANVVFR TLYTLLTFGY
NSQGLAGSLD PFDSYFRARL VCMLLDTCGS YFDHGSSKRK LDSFIIVFQC YLLNKRQPLP
LEVEYAITDC LLSLRRNLVL YNNVTEAQEA LSELEKTFRT KLGESDGGED GGGEESDDED
ERGFDRGGKQ EGEEEEEEGE ENEEEEDVED DEMSDLVDFG DDTAVINKGP ELLKCAEDDD
FLAEFDKMIT ETRRADVPKV PVVDIAIPIT LRKPIEKPAT TSTVEDKGQM KFTVLMKKGN
KPQLKELNVP ADNILASGLK ETQLALENEK KEMKKIVLTH ERRQTEELRQ EEEAQDFYQV
NSSRQNPLRQ PPQHHPAWNP QHHHGNRFKP HPHKKPPGWN SRK
//
