ID A0A1X7VR98_AMPQE Unreviewed; 713 AA.
AC A0A1X7VR98;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=IPT/TIG domain-containing protein {ECO:0000259|SMART:SM00429};
GN Name=100633751 {ECO:0000313|EnsemblMetazoa:Aqu2.1.41948_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.41948_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.41948_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004489}.
CC -!- SIMILARITY: Belongs to the COE family. {ECO:0000256|ARBA:ARBA00010340,
CC ECO:0000256|RuleBase:RU004489}.
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DR RefSeq; XP_011408942.1; XM_011410640.2.
DR RefSeq; XP_019859126.1; XM_020003567.1.
DR AlphaFoldDB; A0A1X7VR98; -.
DR STRING; 400682.A0A1X7VR98; -.
DR EnsemblMetazoa; Aqu2.1.41948_001; Aqu2.1.41948_001; Aqu2.1.41948.
DR GeneID; 100633751; -.
DR KEGG; aqu:100633751; -.
DR eggNOG; KOG3836; Eukaryota.
DR InParanoid; A0A1X7VR98; -.
DR OrthoDB; 3641706at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd11606; COE_DBD; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.3180; Transcription factor COE1, DNA-binding domain; 1.
DR InterPro; IPR032200; COE_DBD.
DR InterPro; IPR038173; COE_DBD_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR003523; Transcription_factor_COE.
DR PANTHER; PTHR10747; TRANSCRIPTION FACTOR COE FAMILY MEMBER; 1.
DR PANTHER; PTHR10747:SF38; TRANSCRIPTION FACTOR COLLIER; 1.
DR Pfam; PF16422; COE1_DBD; 1.
DR Pfam; PF01833; TIG; 1.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|RuleBase:RU004489};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004489};
KW Metal-binding {ECO:0000256|RuleBase:RU004489};
KW Nucleus {ECO:0000256|RuleBase:RU004489};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Transcription {ECO:0000256|RuleBase:RU004489};
KW Transcription regulation {ECO:0000256|RuleBase:RU004489};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004489};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004489}.
FT DOMAIN 241..327
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 608..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..713
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 713 AA; 77150 MW; 86BC78238DF31D50 CRC64;
MAHESSLSPP VPSGEHIPPP LINHTLPQRS TPYYIAAAQF EKQPPDNMRK SNFFHFIISL
FDGQQHRIQV QKAVFKDFYD TVGTDEQEYR NGLIYKLLVV YSDGTQKEEE LCVRLIDSNT
KQLVPYEGTN KNPDFRRVLL THELICSRCL ERRSCGNKND TPSDPIILDN FRLKIFAKCN
QNCLKNAGNP KDSRRRFQVA LYEIDKVSGQ PIACSDSMFV HNNSKHGRRP IYRDNVVGDG
KPCIVSIYPN EGWTTGGSRI TVIGVNFFEG LDIVFGTVPV QSEVLSPNAI AVRTPPATMT
GEVDVTLIFR ASGAQFCISN PGKFLYTAPD DQIFENSFCR IERVIRQQDD PDQLPKDLVL
QRAAELLESC FLSSRGAQSS TVPFGQAPFV YPPSPALIGS NGVFLFTPQP LTPRQGSNGG
MLPMSEGLGG GFGYGGGMPN TNGDVYPRHS YMPQTAFPFP EITQHGDPGG SMSTEVKSES
QMSSPSQQGL HKSTLANGMV MPFNLPYETA PPYGSNSLPL THGAGQVNTN NNNSTSVTDS
AHIGQMAGSN SLAYMSRLFP GGVPPSPGFL MTHTFSPIPT TPTSMSGGGG LNNQFFAFNS
PLLSPTKGRM AKTARPNPLS LSMSNEMPNG ISSPNLGSTF TFPPITPSAL IAPINLPDLT
GGGGGSEVQD PLSVNSGATS GSSTLHSTSL PQTPPPPSSR KRKHDGSPTT ELR
//
