ID A0A1X7VTM7_AMPQE Unreviewed; 1049 AA.
AC A0A1X7VTM7;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=100637149 {ECO:0000313|EnsemblMetazoa:Aqu2.1.43696_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.43696_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.43696_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR RefSeq; XP_011402843.1; XM_011404541.2.
DR AlphaFoldDB; A0A1X7VTM7; -.
DR STRING; 400682.A0A1X7VTM7; -.
DR EnsemblMetazoa; Aqu2.1.43696_001; Aqu2.1.43696_001; Aqu2.1.43696.
DR GeneID; 100637149; -.
DR KEGG; aqu:100637149; -.
DR eggNOG; KOG0923; Eukaryota.
DR InParanoid; A0A1X7VTM7; -.
DR OrthoDB; 5488182at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17974; DEXHc_DHX16; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879}.
FT DOMAIN 414..578
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 596..776
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 108..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1026..1049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 913..940
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 128..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1049 AA; 120259 MW; A5333767EE206C75 CRC64;
MADVVAWVGD QLYEILGLSD RYTAEFLVGL AKKSSSLDGF VSQLESTGAL TIDHKTREFA
SELWARVPHK AVVEKPARAK EREAKLQTQR NKSYQILYDS GDEEEEAIMK KRRSSLSSGK
GIKNSKRNIR KDKSSQWESD SSSSEEEKEM KAKRVRVEEP KEEEEDEWDA MEKEREKDLL
ERDALNERIK KKDKEKTRKI VEKSDKKGYE EARKRLQVAE KDQKKLIPEL RKKSRIRYLG
DRAQDKLAEL DADIIDNEYL FSDTKLTKRE EAEHLRKKKL KELADEHRNA KDMEKIERYH
IPSEKEKPSA RYEEPRKEEL LGPNADLRKW EDEQLGIALV RFGAKDAKEK NKQKEYDLVM
DDEVAFVLAE TVAGSKGENE EEMPEGPSVE ERRKMNLEET RRSLPIFPYR EPLLEAVENH
QILIIEGETG SGKTTQIPQY LYEAGYCSNK MKIGCTQPRR VAAMSVAARV SAEMGVKLGN
EVGYSIRFED CTSERTVIKY MTDGMLLREF LGEPDLESYS VMIIDEAHER TLHTDVLFGL
VKDIARFRPD LKLLVSSATM DTKKFSEFFD DAPIFRIPGR RYPVDLYYTK APEADYLDAA
VVSVLQIHLT QPRGDILVFL TGQEEIETTY EMLKERTAKL GSRIGELVIL PIYANLPSDM
QAKIFEPTPP GARKVVLATN IAETSLTIDG IIFVIDPGFC KQKSYNPRTG MESLVVVPCS
KASSNQRAGR AGRVAAGKCF RLFTSWAYHN EMEDTTIPEI QRTNLGNVVL LLKSLGINDL
INFDFMDPPP PETLMLALEQ LYALGALNHM GELTKLGRRM AEFPVDPAMS KMLIVSEKYG
CSEEILTITA MLSVNNAIFY RPKDRVVHAD TARQSFFRPG GDHLTLLAVY NDWVSTDYST
QWCFDNFIQH RSMKRARDVR DQLEGLMERV EIDLASSEDV VAIRKAITAG YFYHAARLSK
GGYRTAKHQQ VVHIHPNSSL FEDQPRWVIY FELVFTSKEY MRQVIEIDNQ WLLEVAPHYY
KAKDIQDENR KMPKGAGASR DDTRFDNQF
//
