ID A0A1X7VU01_AMPQE Unreviewed; 4157 AA.
AC A0A1X7VU01;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=DNA-dependent protein kinase catalytic subunit {ECO:0000256|ARBA:ARBA00018077};
GN Name=100633457 {ECO:0000313|EnsemblMetazoa:Aqu2.1.43354_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.43354_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.43354_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
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DR RefSeq; XP_019852740.1; XM_019997181.1.
DR STRING; 400682.A0A1X7VU01; -.
DR EnsemblMetazoa; Aqu2.1.43354_001; Aqu2.1.43354_001; Aqu2.1.43354.
DR GeneID; 100633457; -.
DR KEGG; aqu:100633457; -.
DR eggNOG; KOG0891; Eukaryota.
DR eggNOG; KOG3601; Eukaryota.
DR InParanoid; A0A1X7VU01; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05172; PIKKc_DNA-PK; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037706; DNA-PK_dom.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM01344; NUC194; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2896..3561
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3761..4088
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 4125..4157
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 588..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2016..2040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2069..2100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2072..2097
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4157 AA; 469354 MW; 8619489DD6C1C113 CRC64;
MESRIESLWE SLHSSSPQRY SYATEVASDL YSLCVEQITE SELAYSSSVL FNPDNGILKF
LHDVTTLEEF ASCKEELLKL LSNFVKNLSR RVLSHIVPIT DVCVFIFMRE KSAKVKNATL
NLLINTLELC GKTEYSHDLD IPKIADKFFQ AALLPTKHSA TIRGGIYHLL GVLCEWFPEH
LVKISSRLID IYMSNLKSEM TVKKTKKPEL PIISGCLYGL TAYLNNFSQS ASEGSVYAQD
IYKYTRMAID PLANLTRYEV PRAGLSLISR HAAQFREYLV KDSEHMYESL SSWSNHKNKE
CRVVAVNAIG SFFREVSTQI SDPSISRELG ISNYKFFMKC FRSLMNDPDI NHRLLSIAVK
GYGHFAKPCR LYGSMEDLHF MFGEMVQRSE QLFLASVDFT TSSSSVAFEE RFLLPTFIEA
LANISKEIQN LPDVCLSSLQ KLSVLLFHCY PFLSSHVRYQ GSVSLLKLIM AVSSIPTSFK
QFLSHIVYQG VIRSCSLPVV IEAVQGDDSA VVTAAPLADS NDKVMSYLDY VQLWIQLIDY
KKLKGMGMDF DLELRQSIHQ LVYSEFIQSL LNILRKLDFT TASTTEDGIM ANEGEGGGGS
GGGDPVITSD PVLGRQPAVP KDFQIFINLV ELAKKVIPSV SLSLFTPWIL TFSQEVVSLA
TRYPLVSGFY KLLTVCLSIC NKTHFFDVHD LSGQGTGDDD VAMETEERTD RQSCYFLFSS
FIKEVVVQMQ QYKDDLLASC LHLILVLPKE MVVSDFKELI PAIKLALRIG MGYLPLAKSV
MEALEKWTLY IVESDKMDTL QCLVNEILPL LADYLKATSV QLKEEEDGGR GKQYATKRYA
RMKMVEKWSE GLHQGSRDDI TSVRRRILLL LGSLGGVVNE SLSKVPSQHS LVSWDSDRRL
GFAVPFSDLK PEIYLDPYLP TVCELALSSS DRQTKVAACE FLHAAMLFVI GKGTQQSVQK
KNPMTKLYQK LIPVALQLAC DVDRVAEQLF RPLVFQMIHW FTRNTQYESP DTVTLLEAIL
EGIEHPTNAS LRDFSAQCIK EFLVWSIKQT SKKQQERSPM NTKSLLKRLY SMSGHPSTAK
RLGAALAFNS IYTVLREEES LVDVFIIEML VVMVNSLKLA HKDAQSIGTV DQCSLSLDHM
SRIIKAKSST CLSKANKNRR VPRGLKSADL SILTAWLLAQ CGSIETEARK MCRKLLVQLA
PPSSNVVNIR MWIRKTIESE GGNYFVTRFE SHGHSGILKA PTLAPAPNIN IAINWLQSLQ
AAVDNYRWLL KEQYVSPREI FSSTSSSNLF KSIDHFLKCI ALVGIEGVVN SPEVAMATSI
HERGEYQRNK WCTIELLLTF IELLLTKHTS ETVSFEYVPD SLWSQELYTI VMDSLFYSSL
VNTAPDDPST AKRISEAAVS CLTAMCTSLP IDVKQNLIAY IASNINTGQT NNVINRLPVS
YNESTTSSGI LLFNRLVQGH IYLAESNKCL SDVLKSMGIS EEESLAMRLY TNALTIIRGI
SSSPGDGTPG YYMPPLHKLT GELLLKLGLE LSDSVEPFLL LVLSPAQSGA GASFAAQDGL
LLYITYSGLI NNKLLLHIKM AIDVLLKNAK THPQQVSVIL NLLLEYVQKD FKINNNNNNK
ETVETLCTEL ISHWQDLSLW WEDGSKDLKS AAVTLLQKII ALKPKLLLKS ADVSKPLVDM
YTAMIGDEKL ELNFKAVMID LLPSFLLLSS PEHQSQLKGS LNRLVSLQFP LTSSELPAGG
PLLNEYTNII EKLCNSLVAS GSLVLLELII NIMCREVRHV CEEKIQTSLH QFISKLSEDG
VDALKFVYEM FKNDKDFPVA AVKGIGERLC VPLFTECSSA VLLEFFVLKI SDVMCIMEAK
LARVTDPKLE CQLVHKSCCF QFIEILYTRL PSSLISSMES TVNTAYCNGS PQTGKELTQA
ITKCCHGAKS EDLHGDRTHY ETRRQYHCHA YNTLMSVISC TQSKPQFFVG FLFKEDVVKG
QLLWDNIIDC EKKYEFQVDF EAPLKRRKQI TSIRDDLKQS TAAGNSSGSP SSSPSTRPRY
ISSQYLSDSS LSTDVSQYDF TLPHHHQYGS VGGGASTESS SIDEDSGNSQ EASSYVVSEE
QLEEDDLNIH ECMTPLMKLL DHMIINKITP APSGDSPEMP PWMTPLHKRM TDSRTGRNIK
LFIVRLITNR PKIFQPYAKH WLPVLTQFIL SGDSTAGMGG AVGGGENGLD YFTVDAIATM
LSWSSTAIIE DRFLGSQLLE YIMLRSNHKN RSILRNNLEI VRTMVELWKD KIDIPTRVLY
DQFSNSDKST VSNLSGIQLV GIAVANELNP YDTNTAGSLD QGLYYKIFVN NLTFKYKLIY
AAAAEVLGMI MKRMAESYDP FLDRLEEMVG EQLFKLSQPL EKSEDKFITC LHKITLCYNK
IVPRFVEKLL FLLPSLQGVF RSSCLEILDT QADVQPQFYL KLKDKGFHTM ISHRDEATQT
ASLSIVQKLL VQLTNDQLSE IVPILIASFS KHGSIQCRIV LYNILMRVYN KLCTDDQSES
DDSVKMIRSI SRDQLLLGLG DESNEVKLKM YEYWNQESNL SSNTLDRLTQ LLVTLYSKKT
ETQFLYHATN LLLELTSRSP DYNRVLFDTP LSECRFEDYK EIDLSWQQRH LQMTPLFAAT
QLSQTQSDTG SIGTGMLRAT VQQSLAFTPT QGQESSYNWM TPSAQSVDYS VPSFTVGATP
TSDSSLLFTR PTMRPPLKNP LRISAERLGK VGESEGGETK EEKRKQVLQL KKRALKDKEM
VSSFFAMNEA RKKMRREELK KQRRAARQSY VVMYRKYRMG ELPDIQIKHS ELIRPLQALA
QNDSGLARLL FCSLFNSIFS QLDHLLTEED AAATKGVIEG NINTILDCST QYYPPFIGSL
QDICYYENSL KIKPPSITTS SLASKQEFTG IMLLEKQLLL NVDSSKSAKR SRTNKSNEVT
ETWIELARLY KSLEDYDVLH GIFTNLDDTK DVTRKALEAE ERGDYLTALN LYKKAIDFDW
PQGESPPQVE EDLWEDSLLN AYSHLTKWKD LEKASTCNIG EETNSKLEQL WKDSYCQEHY
LPFVLSSKLK LWCTDDSDHG LASFLDKSLS EEANRSVLES HYPQELTLSY VLRDDYDRAY
YYLSLSLKAK QQIWSVQDGI SSSTGAVSST VQSLQRLTEM NEFITFMKSN DNFSSPGPVN
NLLRKWRKRF PDPKLDPVPI WDDIITTRWM MLRKISTKLQ DSVLSQQCEY LLDDDGSSCS
VDSMMKNENI NMFMRAADAA RTQSNYPVAE NYLKIVEKSI LKDFPDNYFI QLRWLHSLIK
VRLDRIHQDP SPTDMEAVIS LTCQMDNFKG RLGGSGKGAI SSKPFISQHH VLLGKLLNKM
AEIFATPEDG MLALSALSND GNTKLNSLIG GTPSTSTKAI SEGLWIQALS SFNAGVRSGT
TLNPLTKDPV PTVQSLEELF GFCDNALRQE DHDDEQSTGL DTKSFPSIII NHTLTAMSLG
SSKARELFPR LLQLVEAHPD TMDLMINKSS TIPCWMFIGW INQMIALVDK PESRAVHDIL
IRIADTYPQS LYYAFRMSSS GYKFGHNNSE GKELFEKLKE KLQSQLMDEF IAALEQLNSP
ELAWKDWYDN ELKPLVGSVT VPKRDKNAIK RVWEQMYSQL LETRSGLGDK SLYGGSPSLQ
KGARQKTFAQ AYAKNIEDKF GKGGAKIISM SGTQLASAFN EVYNKMRESL NKFSSSALLK
DYSPWLDTFR QEDYLQVIEV PGLYDGRSKP LPEYHAKITR FDAKVLILSS LRKPKRLTII
GDDTREYMFL VKGGEDLRLD QRIEQLFETM NKVLSDDPIC SQRRLNLRTY SVIPVTPRVG
LIEWVRNTMP LKDFIQLSDP EKKSLPAASK MNQKWLEQKF GGSNYVNWYY EMYKKLKADE
VKKEYRRIVS AVPWDLLRRS LISLASTSES FLLLRCTFIQ SLSVINICQY ILGIGDRHLS
NFMVDMETGQ LVGIDFGHAF HSATQFLPLP ELMPFRLTPQ FVNLLLPHKV SGQLRSCMIH
TLRALRHSPT LLLNTMDVFI KEPSLEWESN AKKQALAQKI NTDDNTWYPK EKVNICRKKL
LGFNSSHLML IDLEHGFKNK PEFKYLKGIL LGDSSTNLRA RVGKRCDSVE DQVDCLIDHA
TDSNVLGRTY GGWEAWV
//
