ID A0A1X7VVJ8_AMPQE Unreviewed; 976 AA.
AC A0A1X7VVJ8;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN Name=100639467 {ECO:0000313|EnsemblMetazoa:Aqu2.1.43899_001};
OS Amphimedon queenslandica (Sponge).
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC Haplosclerida; Niphatidae; Amphimedon.
OX NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.43899_001, ECO:0000313|Proteomes:UP000007879};
RN [1] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20686567; DOI=10.1038/nature09201;
RA Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The Amphimedon queenslandica genome and the evolution of animal
RT complexity.";
RL Nature 466:720-726(2010).
RN [2] {ECO:0000313|Proteomes:UP000007879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT evolution of animal complexity.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.43899_001}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_019863258.1; XM_020007699.1.
DR AlphaFoldDB; A0A1X7VVJ8; -.
DR EnsemblMetazoa; Aqu2.1.43899_001; Aqu2.1.43899_001; Aqu2.1.43899.
DR GeneID; 100639467; -.
DR KEGG; aqu:100639467; -.
DR eggNOG; KOG1055; Eukaryota.
DR InParanoid; A0A1X7VVJ8; -.
DR OrthoDB; 1011589at2759; -.
DR Proteomes; UP000007879; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF20; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR01176; GABABRECEPTR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007879};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..976
FT /note="G-protein coupled receptors family 3 profile domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013390345"
FT TRANSMEM 616..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 656..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 701..719
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 740..760
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 805..823
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 835..860
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 866..888
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 696..895
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 28..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 976 AA; 111251 MW; BF0A9D7E6A7D7448 CRC64;
MLHLFYSLFI SSLFLSSSSG QGVYGDHFNS SSSGDTPIES GSGSDSPATT TMPPTISTAI
PPPTPPPWFP QDCPCPYGKH LVYLVQPSPC YYEHERNSSS VLSLTSPRAC DIHTYTGMIA
ADYNFVYNSQ PGAPGLTLLN TFCFEPRSYS VITWYPNGKE DLPTMVRNLY YHYKAGNPLH
GVIAPHDQKL SERINYVVGK NIKRLVMSYS TPGLLQNRTV YPYQYTTSPS EIFLNKVRLQ
VLYDFNWRRV AIVSTDDAFS SEAAEQLFSI SRDNTSMDIN FPGSFLRDPT AIFEQLKEDD
YRIFVGFFPL KESRYIICKA MRMGLTTSQH VWILPGIYDY MWWHDCTCDN NDKFCSCNDC
TEEEMKSAIQ GMLFIDASNL QITNVTETQD QIHWFHELFN FTRDFFIFPS IVNITEEDRQ
YLIHSRGTNA YDAIGLFYST WHAAAQRLLS STNDVTAICD SMSKPIRDSN DQLDLLSKTM
VDILETHVFC GVSGYYNYKG KNNNDEFGQA KVTQFQDDHE YTIGIYRNYE FSPDEVYCPR
NKLVELNESR ITFSPSSLFF SNLTNFNFRQ KNFGSSGPYR WKNKNGSFFY NCYTAPTDGA
CHDESCLCFN QIEESGISLS LFIMLIGIIT SVLLILFNFH NRNNKHIKAS SPKFTLFIII
GALVMYVSIL FLALSFSGNF IIKSESSRKI ALPVFCELDK WLSSLGMIIT LSAMLVRNWR
LHKIFYNPKI ANRSYLSDKI LIPMMLLLIA PVCLLLIIWS STDAYKYKEM YEAFNCTDII
VDDSITTELV TYTCSSSPQW RGLLVMYNLL LSCGLIFFSY QNAKIRTHFS QEGEFAARAV
FVVFLFVIPA FAIDLLLILT STNSLGLFWI RLLLAASFPS VVLGGLFVPK IIFMMRDKRE
LEKLKQRQTL SFSYEGKIKE IDHLKSVLSK RESIIALLQK RGSLRNESSP LSMVTTTSSV
FSPSSFPSDF LSFIPE
//
