ID   A0A1X7VWZ2_AMPQE        Unreviewed;       737 AA.
AC   A0A1X7VWZ2;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=TTF-type domain-containing protein {ECO:0000259|SMART:SM00597};
OS   Amphimedon queenslandica (Sponge).
OC   Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha;
OC   Haplosclerida; Niphatidae; Amphimedon.
OX   NCBI_TaxID=400682 {ECO:0000313|EnsemblMetazoa:Aqu2.1.44385_001, ECO:0000313|Proteomes:UP000007879};
RN   [1] {ECO:0000313|Proteomes:UP000007879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20686567; DOI=10.1038/nature09201;
RA   Srivastava M., Simakov O., Chapman J., Fahey B., Gauthier M.E., Mitros T.,
RA   Richards G.S., Conaco C., Dacre M., Hellsten U., Larroux C., Putnam N.H.,
RA   Stanke M., Adamska M., Darling A., Degnan S.M., Oakley T.H.,
RA   Plachetzki D.C., Zhai Y., Adamski M., Calcino A., Cummins S.F.,
RA   Goodstein D.M., Harris C., Jackson D.J., Leys S.P., Shu S., Woodcroft B.J.,
RA   Vervoort M., Kosik K.S., Manning G., Degnan B.M., Rokhsar D.S.;
RT   "The Amphimedon queenslandica genome and the evolution of animal
RT   complexity.";
RL   Nature 466:720-726(2010).
RN   [2] {ECO:0000313|Proteomes:UP000007879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lucas S., Shapiro H., Lindquist E., Tice H., Dalin E., Glavina del Rio T.,
RA   Bruce D., Barry K., Pitluck S., Srivastava M., Simakov O., Chapman J.,
RA   Mitros T., Hellsten U., Putnam N.H., Fahey B., Gauthier M., Larroux C.,
RA   Richards G.S., Stanke M., Adamska M., Darling A., Dacre M., Degnan S.M.,
RA   Zhai Y., Adamski M., Calcino A., Cummins S.F., Goodstein D.M., Harris C.,
RA   Shu S., Woodcroft B., Leys S.P., Manning G., Degnan B.M., Rokhsar D.S.;
RT   "The genome of the haplosclerid demosponge Amphimedon queenslandica and the
RT   evolution of animal complexity.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EnsemblMetazoa:Aqu2.1.44385_001}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2017) to UniProtKB.
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DR   AlphaFoldDB; A0A1X7VWZ2; -.
DR   EnsemblMetazoa; Aqu2.1.44385_001; Aqu2.1.44385_001; Aqu2.1.44385.
DR   eggNOG; ENOG502QPQD; Eukaryota.
DR   InParanoid; A0A1X7VWZ2; -.
DR   OMA; MEENESC; -.
DR   Proteomes; UP000007879; Unassembled WGS sequence.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR025398; DUF4371.
DR   InterPro; IPR008906; HATC_C_dom.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR006580; Znf_TTF.
DR   PANTHER; PTHR45749; -; 1.
DR   PANTHER; PTHR45749:SF29; DIMER_TNP_HAT DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF05699; Dimer_Tnp_hAT; 1.
DR   Pfam; PF14291; DUF4371; 1.
DR   SMART; SM00597; ZnF_TTF; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007879}.
FT   DOMAIN          44..131
FT                   /note="TTF-type"
FT                   /evidence="ECO:0000259|SMART:SM00597"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..32
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   737 AA;  83203 MW;  563D831375BA727A CRC64;
     MQSEERVSSS GAEQHLPNDI AQHKSDSPHQ PSGITFPARM FGSSKRSFQA SWYADYSWLE
     YSIERDSVYC FPCRFFGIAA DQSLTRVGFS DWKHARGKSG TLTGHDTSCS KHHLAVLSWK
     EYQSTVANNS SVAVQLDRCR LQMIEENRLY VKIIFAAILF CCQQGIALRG HREVIDSDDY
     SVNVGNFRAL MVLFSRSIDI VKQRMFNGPK NATWLAKDIQ NSVISLLAES VSSMIREESR
     VARYYTIIAD ETKDVSKTEQ LALVLRYVLD GKTHERFISF TKCEELDAEA IFTYIMTGLR
     DTGVDISNCI SQCYDGASVM SGHLSGVRKR VTDLNPAAIY IHCHAHQLNL VLVDTCKKVD
     HAASFFSLLE CVYVFLSSSV PHSLFMAKQK ELHFTREIQL KKLSDARWSC RHSSIKAVLT
     TIQALLLTLE ELSEDNNTRS IEARGLLHQV SSFQFLLSLI LFERIFSISN NLSTLLQSQK
     ISYAAAASCI KGTMLTIANL RSDDEWSQIW AQAVSMAEKC SITVTPLRQR RSNRLPKQLD
     SFVVDSSVGT RPVNTTDEYK TQVYYATIDA IVEEMDERFS ELNLSLLKSL EPLIPNSSSF
     LDLTVLKPVL NHYNISEAAI VAEVSTVKIF LDERDPDSSS LHDAYQQLSK VPECFPTVIQ
     CYQIAMTIGV SSATAERSFS SLRKVKTYLR STMTQDRLSN LALLYIERSL SSKLWDKLDE
     LVIKFAETHK NSRIVLL
//