ID A0A1X9MH75_9BACI Unreviewed; 718 AA.
AC A0A1X9MH75;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN Name=topB_1 {ECO:0000313|EMBL:ARK31483.1};
GN ORFNames=BkAM31D_17470 {ECO:0000313|EMBL:ARK31483.1};
OS Halalkalibacter krulwichiae.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Halalkalibacter.
OX NCBI_TaxID=199441 {ECO:0000313|EMBL:ARK31483.1, ECO:0000313|Proteomes:UP000193006};
RN [1] {ECO:0000313|EMBL:ARK31483.1, ECO:0000313|Proteomes:UP000193006}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AM31D {ECO:0000313|EMBL:ARK31483.1,
RC ECO:0000313|Proteomes:UP000193006};
RA Krulwich T.A., Anastor L., Ehrlich R., Ehrlich G.D., Janto B.;
RT "Bacillus krulwichiae AM31D Genome sequencing and assembly.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
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DR EMBL; CP020814; ARK31483.1; -; Genomic_DNA.
DR RefSeq; WP_066152823.1; NZ_CP020814.1.
DR AlphaFoldDB; A0A1X9MH75; -.
DR STRING; 199441.BkAM31D_17470; -.
DR KEGG; bkw:BkAM31D_17470; -.
DR Proteomes; UP000193006; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd03362; TOPRIM_TopoIA_TopoIII; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR005738; TopoIII.
DR InterPro; IPR025589; Toprim_C_rpt.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034144; TOPRIM_TopoIII.
DR NCBIfam; TIGR01056; topB; 1.
DR PANTHER; PTHR11390:SF21; DNA TOPOISOMERASE 3-ALPHA; 1.
DR PANTHER; PTHR11390; PROKARYOTIC DNA TOPOISOMERASE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR Pfam; PF13342; Toprim_Crpt; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ARK31483.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000193006};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 1..140
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 718 AA; 81555 MW; DBEBC50497DF53BF CRC64;
MKVIIAEKPD QAVKLAAPFS SIKKTGYIEI KATSLFPQGA YITWAVGHLC ELIPPEMYDQ
KWKTWKLETL PIIPTKFDFK VSKGKEKQFN VIKKLVNDRN VSEIIMAGDA GREGELIVRL
ILNQCKVNKP LKRLWLSSLT KSAVEEGFKS LRSEEETRPL YFEAISRACA DWLVGMNASR
AYTLHLQRKG VNDVFSTGRV QTPTLALIVK REREIEAFKP EPFWEVISTF NINGKKYQGT
WHKDGQTRIQ TAEMAKKIAA FCEGKEALIT DVKIEEKRYQ PPFLPTLSSL QTVANQRFKY
SPKKTLDLAQ KLYVKGYISY PRTDSAFVTK GEASTFPKIL KALSNKTEYA PYFPLPKQSL
IGNTRYVNDR KVTDHYAIIP TEQIPQLDRL TTEERNIYDL VVRSLLAAHE DEAIISTTKI
ETLCDNRATF QSKGKMIKQQ GWRIVYYTDK KSGKEEIYLP NVEKDERGMV QKITVKESVT
QPPKRFTEGQ LINVMKTAGK QINDHELEKI LMESQGLGTE ATRAGIITVL KTRGYMTVSR
NIVAPTEKGR LLIDALGESL LTSAEMTAKW EQRLREIGKG QASSTDFLEQ TKKLVNHLIS
EAEQQITLLD LSSHDLSGFQ RKTKKGKRKP AIVGMCLECG GTIIDHGQFY GCSQYKASNC
RFTISKTILG KKMRQKDIKA LLKDGKTEVL SGFLKEGQSF RAALVWDKER KKITFHYT
//
