ID A0A1Y0FV06_9GAMM Unreviewed; 353 AA.
AC A0A1Y0FV06;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Lipopolysaccharide heptosyltransferase 1 {ECO:0000256|ARBA:ARBA00044190};
DE EC=2.4.99.23 {ECO:0000256|ARBA:ARBA00044041};
DE AltName: Full=ADP-heptose:lipopolysaccharide heptosyltransferase I {ECO:0000256|ARBA:ARBA00044330};
GN ORFNames=CBR65_07310 {ECO:0000313|EMBL:ARU27261.1};
OS Cellvibrio sp. PSBB006.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC Cellvibrionaceae; Cellvibrio.
OX NCBI_TaxID=1987723 {ECO:0000313|EMBL:ARU27261.1, ECO:0000313|Proteomes:UP000196143};
RN [1] {ECO:0000313|EMBL:ARU27261.1, ECO:0000313|Proteomes:UP000196143}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PSBB006 {ECO:0000313|EMBL:ARU27261.1,
RC ECO:0000313|Proteomes:UP000196143};
RA Song R., Chenine A.L., Ruprecht R.M.;
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ADP-L-glycero-beta-D-manno-heptose + an alpha-Kdo-(2->4)-
CC alpha-Kdo-(2->6)-lipid A = ADP + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-
CC (2->4)]-alpha-Kdo-(2->6)-lipid A + H(+); Xref=Rhea:RHEA:74067,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:61506, ChEBI:CHEBI:176431,
CC ChEBI:CHEBI:193068, ChEBI:CHEBI:456216; EC=2.4.99.23;
CC Evidence={ECO:0000256|ARBA:ARBA00043802};
CC -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004713}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004515}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004515}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004515}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 9 family.
CC {ECO:0000256|ARBA:ARBA00043995}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP021382; ARU27261.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y0FV06; -.
DR KEGG; cell:CBR65_07310; -.
DR OrthoDB; 9767552at2; -.
DR Proteomes; UP000196143; Chromosome.
DR GO; GO:0008920; F:lipopolysaccharide heptosyltransferase activity; IEA:InterPro.
DR GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:InterPro.
DR CDD; cd03789; GT9_LPS_heptosyltransferase; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR002201; Glyco_trans_9.
DR InterPro; IPR011908; LipoPS_heptosylTferase-I.
DR NCBIfam; TIGR02193; heptsyl_trn_I; 1.
DR PANTHER; PTHR30160:SF19; LIPOPOLYSACCHARIDE HEPTOSYLTRANSFERASE 1; 1.
DR PANTHER; PTHR30160; TETRAACYLDISACCHARIDE 4'-KINASE-RELATED; 1.
DR Pfam; PF01075; Glyco_transf_9; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Lipopolysaccharide biosynthesis {ECO:0000256|ARBA:ARBA00022985};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000196143};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ARU27261.1}.
SQ SEQUENCE 353 AA; 39633 MW; 7EBE804A0C629C21 CRC64;
MKILLIKMSS MGDIFHTFPA ITDLKEKYPE VVIDWVVEEG FAEIAAWHPA IRRVIPIDLR
RWMKQKNWSS WSAFRQWRKA LKSEHYDCVI DAQGLLKSAL VTRFASADTL HGYDKKSARE
SISSRFYSHT HAVSKEQHAV ERTRQLFASI FSYTPPPALN FGINQNFARV QKDSRKLVFI
IGTSWTTKLW STAHWQTLAK IAVEQGYNLE IIWGSESERI IADQIMAVCP TANRPQQRLS
ITTIAEKLVE AAGVIGLDTG FSHLAGALET PTIALYGPTS PIKVGLIGAH TCNLQMENPL
DCIPCHKRSC RLLPEHSSET PPCMTGILAV QVWNNLQQKL PDASGTDPSP RLS
//
