ID A0A1Y0GAY3_9PROT Unreviewed; 484 AA.
AC A0A1Y0GAY3;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Magnesium transporter MgtE {ECO:0000256|RuleBase:RU362011};
GN ORFNames=CAP31_12990 {ECO:0000313|EMBL:ARU32514.1};
OS Sulfuriferula sp. AH1.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Sulfuricellaceae; Sulfuriferula.
OX NCBI_TaxID=1985873 {ECO:0000313|EMBL:ARU32514.1, ECO:0000313|Proteomes:UP000195558};
RN [1] {ECO:0000313|EMBL:ARU32514.1, ECO:0000313|Proteomes:UP000195558}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AH1 {ECO:0000313|EMBL:ARU32514.1,
RC ECO:0000313|Proteomes:UP000195558};
RA Jones D.S., Hua A.A., Roepke E.W., Bailey J.V.;
RT "The complete genome sequence of Sulfuriferula sp. str. AH1, a sulfur-
RT oxidizing autotroph isolated from weathered sulfide-bearing rock from the
RT Duluth Complex.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a magnesium transporter.
CC {ECO:0000256|RuleBase:RU362011}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU362011}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362011};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362011}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC41A transporter family.
CC {ECO:0000256|ARBA:ARBA00009749, ECO:0000256|RuleBase:RU362011}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362011}.
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DR EMBL; CP021138; ARU32514.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y0GAY3; -.
DR KEGG; sulf:CAP31_12990; -.
DR OrthoDB; 9790355at2; -.
DR Proteomes; UP000195558; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd04606; CBS_pair_Mg_transporter; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.25.60.10; MgtE N-terminal domain-like; 1.
DR Gene3D; 1.10.357.20; SLC41 divalent cation transporters, integral membrane domain; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR006668; Mg_transptr_MgtE_intracell_dom.
DR InterPro; IPR038076; MgtE_N_sf.
DR InterPro; IPR006669; MgtE_transporter.
DR InterPro; IPR006667; SLC41_membr_dom.
DR InterPro; IPR036739; SLC41_membr_dom_sf.
DR NCBIfam; TIGR00400; mgtE; 1.
DR PANTHER; PTHR43773; MAGNESIUM TRANSPORTER MGTE; 1.
DR PANTHER; PTHR43773:SF3; MAGNESIUM TRANSPORTER MGTE; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01769; MgtE; 1.
DR Pfam; PF03448; MgtE_N; 1.
DR SMART; SM00116; CBS; 2.
DR SMART; SM00924; MgtE_N; 1.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF161093; MgtE membrane domain-like; 1.
DR SUPFAM; SSF158791; MgtE N-terminal domain-like; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Cell membrane {ECO:0000256|RuleBase:RU362011};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU362011};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362011};
KW Metal-binding {ECO:0000256|RuleBase:RU362011};
KW Reference proteome {ECO:0000313|Proteomes:UP000195558};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362011};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362011};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362011}.
FT TRANSMEM 392..414
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362011"
FT TRANSMEM 421..445
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362011"
FT TRANSMEM 457..480
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362011"
FT DOMAIN 172..235
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 236..292
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 484 AA; 53052 MW; 2E3E81DA2163D4E0 CRC64;
MAENFDTGKA HDSTEDNLNR VVELLRKHDL VASLVHKQDM PRRDLVEGLV HKQHLAALHT
LLDDMHSADV ARVLEALPLD DRLLVWDLVK AERDGEILLE VSDAVRESLI KAMDSDELLA
AAETLDTDEI ADLAPDLPQD VIQDLLESLD AQKRSRLQSA LSYPEDTVGA LMDYDMVTIR
ADITLEVALR YLRRLGELPD QTDKLFVVDR EGALRGVMPL QRLLLKDPDA KVADVMAEEV
VTFHAEDDAT DAANAFERYD LVSAPVIDGR NRLMGRLTVN AVVDHIRQES DSDLLSIAGL
REEEDIFASV WKSVQNRWAW LAINLVTAFI ASRVIGEFEG TIEKLVALAA LMPIIAGIGG
NSGNQTLTMI VRALALGQIH PDNARKLFSK EIGVAAINGV IWGSVVGVFA YLLYDKPALG
VVMMGAMTLN LLLAAVMGVA IPTLMHKFGR DPAVGSSVMI TAVTDSGGFF IFLGLASLFM
RYLS
//
