ID A0A1Y0ILR6_9BACL Unreviewed; 415 AA.
AC A0A1Y0ILR6;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN ORFNames=CBW65_09725 {ECO:0000313|EMBL:ARU61240.1};
OS Tumebacillus avium.
OC Bacteria; Bacillota; Bacilli; Bacillales; Alicyclobacillaceae;
OC Tumebacillus.
OX NCBI_TaxID=1903704 {ECO:0000313|EMBL:ARU61240.1, ECO:0000313|Proteomes:UP000195437};
RN [1] {ECO:0000313|Proteomes:UP000195437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR23208 {ECO:0000313|Proteomes:UP000195437};
RA Sung H.;
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938,
CC ECO:0000256|RuleBase:RU003423};
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317, ECO:0000256|RuleBase:RU003423}.
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DR EMBL; CP021434; ARU61240.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y0ILR6; -.
DR KEGG; tum:CBW65_09725; -.
DR OrthoDB; 9805770at2; -.
DR Proteomes; UP000195437; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR CDD; cd06849; lipoyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 4.10.320.10; E3-binding domain; 1.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR004167; PSBD.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02817; E3_binding; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS51826; PSBD; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003423}; Lipoyl {ECO:0000256|RuleBase:RU003423};
KW Transferase {ECO:0000256|RuleBase:RU003423}.
FT DOMAIN 2..77
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 90..127
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
FT REGION 140..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 415 AA; 44590 MW; 4B8FCAD11DA30C6C CRC64;
MTVAFKLPDV GEGIHEAEVV RWLVQEGDVV REFDPLVEVQ TDKALVELPS PASGCVQEIK
AKEGELARVG EVLVVIGEKQ ESVPAAKRVL ATPSTRKFAR DQGVDIAQVT GTGPAGRVTK
EDVQAFLHTK ENTVAPAATQ VSNTANSPAP SSTVLATAPT NTSANSPTTA PTTTQTSAPT
TASTTRIPLR GLRRTIADRM AKSAFTAPHV TAVDEVDMTE LVAYRAHANE LLAPTRQKIT
YLPFILKALT TALKSHPHLN AHMDDAAGEI VLHSDYHIGI AVDTEDGLMV PVIKHADRRS
LLDLAAAAKT LTDQAKTRTL ALDDMRGGTF TISNMGPIGG LFATPILNYP EVAILGIHAM
QDRPVVRGGE IVIRTMMNLS LSFDHRVIDG AEAVRFTNKI KQLLETPQRL FLEMS
//
