ID   A0A1Y0ILX2_9BACL        Unreviewed;      1078 AA.
AC   A0A1Y0ILX2;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=CBW65_11260 {ECO:0000313|EMBL:ARU61522.1};
OS   Tumebacillus avium.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Alicyclobacillaceae;
OC   Tumebacillus.
OX   NCBI_TaxID=1903704 {ECO:0000313|EMBL:ARU61522.1, ECO:0000313|Proteomes:UP000195437};
RN   [1] {ECO:0000313|Proteomes:UP000195437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR23208 {ECO:0000313|Proteomes:UP000195437};
RA   Sung H.;
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; CP021434; ARU61522.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y0ILX2; -.
DR   KEGG; tum:CBW65_11260; -.
DR   OrthoDB; 9810135at2; -.
DR   Proteomes; UP000195437; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          12..427
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          431..684
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         33..40
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1078 AA;  122383 MW;  591A20583BBC2D8B CRC64;
     MKKCDRGMPN LIELTKMQQQ AVEAKGERIL VSAGAGSGKT RVLVERFAHL VEQHGCPPEK
     IAALTFTDQA AAEMKERILA RIRTGQADLH VLTFHRFCGQ ILRENPLLAD VDPAFSILPD
     SRAKHLLRRL VMQQLRESED PQIGLLLQQV QSVDLADILL ALMQKGRERP LTWDEWRVQT
     EQTAMDLRKR AWSSLQESLR ALQEFEQSRV VTAPGTVLRM EKIGKLWNGL SPQLRASGPE
     RWDADAVSEM YPVLEAIMSE VTLTVAQAAK PLFARLSKLK KEKLWEDLLT DQTASLRHSL
     FDLMSRTHRE YEASKQTAGW CDFSDLQDRV YHLLSRHQGV RERYGSLYSH VLVDEYQDTN
     PLQQAILELL EQGRRETNTA GSLFMVGDRR QSIYRFRGAE VKGFDAVQAA LGERDCYLEL
     RDNFRSTASL HALVSDLSAT LFAEPVPETK EAVRADFPDL EILVPAFEER RSMTESEAHL
     LARRLRQLGP GVWGDTAILL QTRTHLAVFA KALHSSGIPY VMHEDSRFWS SQEVQDLLHV
     LRVLADPEDA VALLGFLRGP LIRMPDVELW KLAGASGLVQ GFWMVQSAAR AELERWRVEL
     STQPLTDWLH HLLYGERLEA KIGGRSLGIL VQLAEEGEEH GIVTLDALLA WWRDLEAAGE
     KVSGRSRTQE QNAVKIMTIH AAKGLEFPIV CLPDLTHRQS AMMKRFHLCE QQGLAIRSVA
     KQGGQTLAYA AAAQRETAAL AEEKKRLFYV GVTRAKEKVI LSGAASACTE KRALEECSNW
     WDWLPFLFPD LQEKGLCDRE ILGRGWKAQV LNDASIPVFA KVRVQEAVEL LTESDQAERQ
     EVPRLLFRPS QKIWRVTELT ARLTGQEENE APPWMYQPRS QREQGLRPQE WGQIVHAVFE
     HLTPHDDEQA IRAQRIPAAL ARAGYADAAL TAEVWERMRE ELAMYRRSAL FQEMSRAVHR
     EHEVPFSMEL APGLQVNGVI DALWLRDDGK ATIVDYKTRR CETEREVEQL MAQYGTQVQL
     YALAVERLLG WEVDRVGVYM TAMGRFVEVG YGKEVREELL KGASLVAERE QEVWDLSS
//