ID A0A1Y0ISM4_9BACL Unreviewed; 2181 AA.
AC A0A1Y0ISM4;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=CBW65_18885 {ECO:0000313|EMBL:ARU62806.1};
OS Tumebacillus avium.
OC Bacteria; Bacillota; Bacilli; Bacillales; Alicyclobacillaceae;
OC Tumebacillus.
OX NCBI_TaxID=1903704 {ECO:0000313|EMBL:ARU62806.1, ECO:0000313|Proteomes:UP000195437};
RN [1] {ECO:0000313|Proteomes:UP000195437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR23208 {ECO:0000313|Proteomes:UP000195437};
RA Sung H.;
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; CP021434; ARU62806.1; -; Genomic_DNA.
DR KEGG; tum:CBW65_18885; -.
DR OrthoDB; 9765680at2; -.
DR Proteomes; UP000195437; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd12115; A_NRPS_Sfm_like; 1.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 1019..1094
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2080..2155
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 28..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2161..2181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2181 AA; 241238 MW; A83DA8911D2C998E CRC64;
MDNNKTDIQE KRSTLTAAQR ELLKRRMRGE ATAPAAVKPS GIPRRPAGDI PLSFSQQRVW
LLDQLEPGTA TYNIPYAVQM TGDLRLDVLE RALNEIVARH EALRTVFTAG EEEAVQTVLP
HLTLTVPLID LTALPAGERE AETARLTEQE SKRPFDLAAG PMLRATVLQH GADAYTLVLV
IHHIIGDGWS FGVLIREMAA LYDAFLTGRP SPLEALPVQY GDFAHWQREW MQGEVLQKQL
GYWKDQLGQE LTTLHLPTDR SRPAMQTFTG ALYDFWLPKE LEHRLEALGK GEGATLYMTL
LAAFKTLLYR YTMQEDITVG SPIANRNKGE IEGLIGFFVN TLVMRTGVGG DLSFRDVLSR
VKETAVGAFA NQDLPFEKLV EELQPERNMS YSPLFQVMFA LQNAPVPELK LSGLHLQAQE
LDSGTSKFDL SLYMMQKESG LLARFEYNTD LFDRATMERM GKHLHNLLDS ILSDAGQTIA
TLPLLTAQEA SLFAGEWNGP QADFPQEETV YSLFEAQAAR TPDAPAVLFE NQTLTFGELN
ARANQVARYL QKQGVTPQGL VGISMERTPE MITALLGIMK TGAAYVPVDP GYPEERKAYM
LEDSGVNLLL TQSRVLETLP VHSAKAVCLD TDWAEIAEES QDNLGVQPDP SSIWYVLYTS
GSTGKPKGVE GTYRAMVNRF QWMWNSYPFA AGDVCSQKTS LNFGDSIWEI WGPLLQGVPL
VIFSDLTVKD IEQFVPALRT HKVTRIVLVP SLLRALLDTY DDLQQELPDL KFWVCSGEAL
TVELTQRFHK ALPAAQLLNL YGSTEVAADV TYYETEKVLP GAVNIPIGRP IANAELYILD
RNLQQVPIGV PGELCAGGAV LARGYYKRPD LTAERFLPNP FGQGRLFKTG DVVRWLPDGN
IEFLGRVDNQ VKVRGFRIEL GEIEAALIQH DDVHSTIVTV REDIPGDKRL VAYSVPLEGA
EVSAGDLRQF LQNKLPEYMV PSAFVMLEAL PLTPSGKINR LALPAPDGAA GQAERPFVAP
RTAVEAELAA IWQEVLRLEQ VSADAHFFEL GGHSLLATQI LSRVRRAFEV SLPLKLFFEA
PTLQALAEQI EAAQSEGKGL QTPPVLPQPR AEYMPMSSSQ ERLWFFEQLQ PGTPTYNIPE
VVRIQGAIDF DALQSALNEL VRRHENLRTS FHMVGGQPVQ KIEPFTPRPL PVIDLQGLPE
TERYPRGKEL ATELYKRPFT LSDGAPFSLT LLRLSEQDHI LVLMMHHIIT DGWSMSRIYQ
ETLALYDRYS QGEVSDLPEL PVQYADYAVW QRELLNGAGL DGQLAYWREQ LQGPLPVLQL
PTDRPRPAQQ TFRGNSFSFE VPRSLSDELH LLARQEGVTL YMLLLAAFNT LLSRYSGQED
ILLGSPVANR TREEVEGLIG FFVNTIVLRT DLSGAPTFRE LLARVKQTTL DAYANQDVPF
ERLVEAVRPE RSSSHSTLIQ AVFALLNTPG SALQVEGLQV ELPGMTLTRL GVEKESVDYD
FVINMVDNEN GLRGVCEYNA DLFDTATIQR LLRHFIALLG AILDNPERSI TELPFLSETE
REQALAIGAN TGTLALQDTL IHHSFERQAA QTPDATALVV GETRLSYAQL NRQANAVAAR
LQQLGVVPGA LVGIYMDRSA DMVIGMLGVL KAGGAYVPLD PAYPQERVLY TMEDAKLAVL
LTQAHLLHDL PEHGAEKLCL PLPETELAAD DNLTSAVIER DLAYVIYTSG STGRPKGVAI
EHRSAATMIE WAKAEFSQAE LAGVLFATSI CFDLSVFELF VTLAAGGTVL LAENALHLPE
LAARDDVTLI NTVPSAIAEL LRLNAIPSSV RTVNLAGEAL PLHFVQKLYA LGTVEKVYNL
YGPSEDTTYS TYAMIDRETA TAPVIGRPLP NTQAYLLDAH LQPVPTGVAG QLYLAGDGLA
RGYLGRDDLT AEKFIGDPFS AAPDARMYAT GDLARWLPDG NLEYLGRLDH QVKLRGFRIE
TGEIETLLLR HAAVREALVL LREDEPGQAR LTAYLVTAAE GETPESNELR SLLKQQLPEY
MVPGHFVCLT AFPLSPNGKV DRKRLPAPEQ GTGAATDYVA PRNETEAKLA AIWQELLRLE
RVGVHDSFFE IGGHSLIATR MVVEIQETFG ILVPLKELFE AVTISELATL IEQVQLTGGA
TEPEKPAIKA MQRTARTSRR S
//
