ID   A0A1Y0ITD6_9BACL        Unreviewed;       606 AA.
AC   A0A1Y0ITD6;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=VWFA domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=CBW65_17990 {ECO:0000313|EMBL:ARU62653.1};
OS   Tumebacillus avium.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Alicyclobacillaceae;
OC   Tumebacillus.
OX   NCBI_TaxID=1903704 {ECO:0000313|EMBL:ARU62653.1, ECO:0000313|Proteomes:UP000195437};
RN   [1] {ECO:0000313|Proteomes:UP000195437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR23208 {ECO:0000313|Proteomes:UP000195437};
RA   Sung H.;
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP021434; ARU62653.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y0ITD6; -.
DR   KEGG; tum:CBW65_17990; -.
DR   OrthoDB; 9780136at2; -.
DR   Proteomes; UP000195437; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR024163; Aerotolerance_reg_N.
DR   InterPro; IPR011933; Double_TM_dom.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   NCBIfam; TIGR02226; two_anch; 1.
DR   PANTHER; PTHR37464; BLL2463 PROTEIN; 1.
DR   PANTHER; PTHR37464:SF1; BLL2463 PROTEIN; 1.
DR   Pfam; PF07584; BatA; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        59..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        583..602
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..78
FT                   /note="Aerotolerance regulator N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07584"
FT   DOMAIN          90..192
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|Pfam:PF13519"
SQ   SEQUENCE   606 AA;  65952 MW;  D8D916CE2ABFAEAF CRC64;
     MNWMSPWMLS FLAALPVIVV LYLLKRTYEK VTVPSTLLWG QVLREMEANR PWQKLRRNLL
     LLLQLLLALL LALALARPAL YGEGPVAEHT IIVLDLSPSM AATGPDDTRL EAGKKKVKEL
     INQLNPPQRM TLIAMGQEPR VLVSGSDRAE LASRLDTAAQ EYGLADYEGA LSLAAALSVQ
     EPNSDVRIYS DGNWGIDPAL LPKFGRQPTV ETLDVQANLG IYHAAGLVSG SEGQLVATVK
     NDGDQQVSAD VEVLDEQGQV LDAKQVQLAA DGQTPLTWTH LPAQTYYEVR LGGQDALAAD
     NRVTVLPQVS KAKKVWLSTA GNVFLEKALS IGGNTTVERG ADPDLPPEDA DLYVYDGVLP
     ITWPNGAVLL VNPPQGEGIF KSGSLLEPGK LQAVQTDSPL LQHIELEKVH LKAVRQLDAP
     AWLQPVAKSG DTPMLLAGDN EGRRVAVLAF DLHQSDLPLL PSFPILIKQL KEYLAPASGT
     AIGQVTAGER IALLPPVREQ GWTVTDPSGE QTRVTGEMIE LGFKPALPGL YRFQGKTERE
     VKLLAVTLPE AESKLDAQKA ALPTDTTEEQ GAERQAQSGQ YEIWRWLALL ALLVLFVEWG
     VYKRGI
//