ID   A0A1Y0KT93_9PSED        Unreviewed;       689 AA.
AC   A0A1Y0KT93;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:ARU88901.1};
GN   ORFNames=B9K09_13405 {ECO:0000313|EMBL:ARU88901.1};
OS   Pseudomonas sp. M30-35.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=1981174 {ECO:0000313|EMBL:ARU88901.1, ECO:0000313|Proteomes:UP000196445};
RN   [1] {ECO:0000313|EMBL:ARU88901.1, ECO:0000313|Proteomes:UP000196445}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M30-35 {ECO:0000313|EMBL:ARU88901.1,
RC   ECO:0000313|Proteomes:UP000196445};
RA   He A., Zhao Q., Li H., Zhang J.;
RT   "Complete genome sequence of the plant growth-promoting rhizobacterium
RT   Pseudomonas rhizovicinus strain M30-35.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
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DR   EMBL; CP020892; ARU88901.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y0KT93; -.
DR   OrthoDB; 5389341at2; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000196445; Chromosome.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-KW.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR   PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW   Reference proteome {ECO:0000313|Proteomes:UP000196445}.
FT   DOMAIN          298..474
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          478..570
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   689 AA;  74432 MW;  8F72A180F5C786F7 CRC64;
     MHKPNISGRV HLIMEDDVAV IIIDNPPVNA STDAVRKGIL AALAGIDVAT TRAVLLTGEG
     RNLMAGADLA ELEHEPTEPT LPSVTAALTD FPLPVIALIK GHTLGGGLEL AMACDLRLGA
     PKASLGLPEV TVGVLPGAGG TQRLPRLIGL SEALSMVVTG KPIDVRNAKQ LGLVDHLLTE
     SEPEAQHQEA LKFARDNKLS KRTLSDEPVE LADELSISEQ VEQLLRRAKG LPSARIAAQT
     VLDSTRLNLA DGLAHERRQF LTLRGSEPAQ ALRYVFFAER GEALAKSTAF EPLPIKRVAI
     IGAGTMGIGI ALCAINAGYS VDLIELNADA LEAGISRIQH ELDNDVSRQR LSAEKRDSAL
     AKLNPTQSIT CVAAADLVIE AIIEDLAAKQ SLLKNLGELV RPDTLLATNT SYLDINEIAA
     QVLNRERVLG LHFFSPANRM ALLEIVKTES TSVLSLRTAL GFAKRLKKKP IIVANSWGFV
     GNRLYAAYRR QCEFLLEEGA TPWQVDEALE EYGFAMGPFK VADLSGLDIA WRMRQKIAEK
     RHLSRYVGIA DALCEANRFG RKTGSGYYAY PANGKPTPDS YTEKLIQDYR ASSGIEAKVF
     SPEDIQQRAV YALINESLLL LNEGVCQRPE DIDIALVNGY GFPKWRGGPF FIARHMSEPD
     LDNALQSLAS ISGKGHVKGD AALAQPSVA
//