GenomeNet

Database: UniProt
Entry: A0A1Y0KTG0_9PSED
LinkDB: A0A1Y0KTG0_9PSED
Original site: A0A1Y0KTG0_9PSED 
ID   A0A1Y0KTG0_9PSED        Unreviewed;       171 AA.
AC   A0A1Y0KTG0;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase {ECO:0000256|HAMAP-Rule:MF_00405};
DE            EC=4.2.1.59 {ECO:0000256|HAMAP-Rule:MF_00405};
DE   AltName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA {ECO:0000256|HAMAP-Rule:MF_00405};
DE   AltName: Full=Beta-hydroxydecanoyl thioester dehydrase {ECO:0000256|HAMAP-Rule:MF_00405};
DE   AltName: Full=Trans-2-decenoyl-[acyl-carrier-protein] isomerase {ECO:0000256|HAMAP-Rule:MF_00405};
DE            EC=5.3.3.14 {ECO:0000256|HAMAP-Rule:MF_00405};
GN   Name=fabA {ECO:0000256|HAMAP-Rule:MF_00405};
GN   ORFNames=B9K09_12585 {ECO:0000313|EMBL:ARU88748.1};
OS   Pseudomonas sp. M30-35.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=1981174 {ECO:0000313|EMBL:ARU88748.1, ECO:0000313|Proteomes:UP000196445};
RN   [1] {ECO:0000313|EMBL:ARU88748.1, ECO:0000313|Proteomes:UP000196445}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M30-35 {ECO:0000313|EMBL:ARU88748.1,
RC   ECO:0000313|Proteomes:UP000196445};
RA   He A., Zhao Q., Li H., Zhang J.;
RT   "Complete genome sequence of the plant growth-promoting rhizobacterium
RT   Pseudomonas rhizovicinus strain M30-35.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Necessary for the introduction of cis unsaturation into fatty
CC       acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-
CC       (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can
CC       catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with
CC       saturated chain lengths up to 16:0, being most active on intermediate
CC       chain length. {ECO:0000256|HAMAP-Rule:MF_00405}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2E)-decenoyl-[ACP] = (3Z)-decenoyl-[ACP];
CC         Xref=Rhea:RHEA:23568, Rhea:RHEA-COMP:9639, Rhea:RHEA-COMP:9927,
CC         ChEBI:CHEBI:78467, ChEBI:CHEBI:78798; EC=5.3.3.14;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00405};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(3R)-hydroxydecanoyl-[ACP] = (2E)-decenoyl-[ACP] + H2O;
CC         Xref=Rhea:RHEA:41860, Rhea:RHEA-COMP:9638, Rhea:RHEA-COMP:9639,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:78466, ChEBI:CHEBI:78467;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00405};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O;
CC         Xref=Rhea:RHEA:13097, Rhea:RHEA-COMP:9925, Rhea:RHEA-COMP:9945,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:78784, ChEBI:CHEBI:78827; EC=4.2.1.59;
CC         Evidence={ECO:0000256|ARBA:ARBA00001055, ECO:0000256|HAMAP-
CC         Rule:MF_00405};
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005194, ECO:0000256|HAMAP-Rule:MF_00405}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738, ECO:0000256|HAMAP-
CC       Rule:MF_00405}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00405}.
CC   -!- SIMILARITY: Belongs to the thioester dehydratase family. FabA
CC       subfamily. {ECO:0000256|ARBA:ARBA00006714, ECO:0000256|HAMAP-
CC       Rule:MF_00405}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP020892; ARU88748.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y0KTG0; -.
DR   OrthoDB; 9786735at2; -.
DR   UniPathway; UPA00094; -.
DR   Proteomes; UP000196445; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008693; F:(3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008659; F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0034017; F:trans-2-decenoyl-acyl-carrier-protein isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd01287; FabA; 1.
DR   Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR   HAMAP; MF_00405; FabA; 1.
DR   InterPro; IPR010083; FabA.
DR   InterPro; IPR013114; FabA_FabZ.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   NCBIfam; TIGR01749; fabA; 1.
DR   PANTHER; PTHR30272; 3-HYDROXYACYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE; 1.
DR   PANTHER; PTHR30272:SF8; 3-HYDROXYDECANOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE; 1.
DR   Pfam; PF07977; FabA; 1.
DR   SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00405};
KW   Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160, ECO:0000256|HAMAP-
KW   Rule:MF_00405};
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832, ECO:0000256|HAMAP-
KW   Rule:MF_00405};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|HAMAP-Rule:MF_00405};
KW   Lipid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00405};
KW   Lipid metabolism {ECO:0000256|HAMAP-Rule:MF_00405};
KW   Lyase {ECO:0000256|HAMAP-Rule:MF_00405};
KW   Reference proteome {ECO:0000313|Proteomes:UP000196445}.
FT   ACT_SITE        70
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00405"
SQ   SEQUENCE   171 AA;  18748 MW;  4B183789B6E73FC3 CRC64;
     MTKQNAFTQE DLLRCSRGEL FGEGNAQLPA PNMLMMDRIV HISEVGGKYG KGEIVAELDI
     NPDLWFFGCH FEGDPVMPGC LGLDAMWQLV GFYLGWQGNP GRGRALGSGE VKFFGQVLPT
     AKKVTYNIHI KRTITRSLIL AIADGTVSVD GREIYSAEGL RVGLFTSTDS F
//
DBGET integrated database retrieval system