ID A0A1Y0M5S1_9FLAO Unreviewed; 773 AA.
AC A0A1Y0M5S1;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BTO04_02025 {ECO:0000313|EMBL:ARV05548.1};
OS Polaribacter sp. SA4-10.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae.
OX NCBI_TaxID=754397 {ECO:0000313|EMBL:ARV05548.1, ECO:0000313|Proteomes:UP000195822};
RN [1] {ECO:0000313|EMBL:ARV05548.1, ECO:0000313|Proteomes:UP000195822}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SA4-10 {ECO:0000313|EMBL:ARV05548.1,
RC ECO:0000313|Proteomes:UP000195822};
RA Kumagai Y., Yoshizawa S., Kogure K., Iwasaki W.;
RT "Trade-off between light-utilization and light-protection in marine
RT flavobacteria.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP019331; ARV05548.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y0M5S1; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000195822; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000195822}.
FT DOMAIN 6..291
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 292..573
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 27..34
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 773 AA; 88349 MW; 5FAAA08EB8A0DA5F CRC64;
MNNYLDSLNE AQKQAVLQKD GPMIIIAGAG SGKTRVLTYR IAHLMKQGVD SFNILSLTFT
NKAAKEMKER IASVVGASEA KNLWMGTFHS VFARILRSEA DKLGFPSNFT IYDSQDSVRL
ISSIIKEMNL DKERYKPKQI LNRISSFKNS LITVRAYFNN SDLKEADLHA SRPEVGNIYK
EYVDRCFKAG AMDFDDLLLR TNELLARFPE SLAKYQNRFR YIMVDEYQDT NHSQYLIVKA
LADRFQNICV VGDDSQSIYS FRGANIQNIL SFQKDYPEVK TFKLEQNYRS TSTIVNAANS
VIARNKTKLD KEVWTSNDAG ESINVMRTIS DGEEGRFVAQ SIWENKMNHQ LKNDQFAVLY
RTNSQSRAIE DALRKKSIEY KIYGGISFYQ RKEIKDILSY LRILINPNDE EALKRIINYP
ARGIGATTID KLTIAANHYK KSIFDILKYI DKIDLKINSG TKTKLQNFVN MMLRLQIESQ
TKNAFEISEI VVKQTQLIKD LEKEGTPEAV SKVENVQELL NGIKDFITDK IEQGEDASLT
TFLEDVALAT DFDSNKEDDK PSVSLMTIHQ SKGLEYSHVY VVGLEENLFP SAMSMSTRSE
LEEERRLFYV ALTRAEKVAY LSYAQTRYRW GKLVDAEPSR FLEEIDDQYL HYITPKVPEP
SINKFVDKSL FDDAPKGIRF QKPIQRKKVE RDLAKKKEIV VPKNLKKVTQ ATSSSNLFDN
DIAVGNIIEH ERFGRGEVLS LEGKGPDKKA MIQFGTAGKK NLLLRFVKLK IIG
//
