ID A0A1Y0MNK4_9FLAO Unreviewed; 1847 AA.
AC A0A1Y0MNK4;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Alpha-2-macroglobulin {ECO:0008006|Google:ProtNLM};
GN ORFNames=BTO09_06220 {ECO:0000313|EMBL:ARV11962.1};
OS Gilvibacter sp. SZ-19.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Gilvibacter.
OX NCBI_TaxID=754429 {ECO:0000313|EMBL:ARV11962.1, ECO:0000313|Proteomes:UP000196054};
RN [1] {ECO:0000313|EMBL:ARV11962.1, ECO:0000313|Proteomes:UP000196054}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SZ-19 {ECO:0000313|EMBL:ARV11962.1,
RC ECO:0000313|Proteomes:UP000196054};
RA Kumagai Y., Yoshizawa S., Kogure K., Iwasaki W.;
RT "Trade-off between light-utilization and light-protection in marine
RT flavobacteria.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
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DR EMBL; CP019333; ARV11962.1; -; Genomic_DNA.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP000196054; Chromosome.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 2.60.40.3710; -; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR041203; Bact_A2M_MG5.
DR InterPro; IPR041462; Bact_A2M_MG6.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR032812; SbsA_Ig.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF13205; Big_5; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF17972; bMG5; 1.
DR Pfam; PF17962; bMG6; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000196054};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 986..1128
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 1192..1282
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1847 AA; 205649 MW; 150D1FBEDAF1479F CRC64;
MKSLFRASLV LLLLATACKP KSTQNDQLFQ YRDYLSYHTQ GVRSVHAPIV LDFLRPLANF
DAQAQLPASS FKIRPSVTGT LKISNGRSLI FTPNEALKAD TEYSVTVNLS DFLEDLPDDK
RQFTFSFKTI APNFKVDLGQ LQSYNKSYQF LQGSIQAADG LYLNQARELV SVSQGGAQLA
VKWDSLGGPN KYYSFVIDSI ARAENDSEIQ IRWDGKAIGA DNKGTAPFVI PGRNNFTVLD
VNTSEAPSTR LTINFSDPVD PDQDFRGLVN LGGNDNLRFE ADGNSLLIYP ASRPQGDLDL
VVFAGLKNTD GYALKNSYSD TVTFDPLKPQ VNLLSKGTII PNAKNNPIYF ETVNLAQIDV
RVVEIFQDNL LQFLQESSLN NSSDYYLRRV GRRVAKKTLQ LVDTNMVSAN SWKAHALDLT
ELFDASPGSV YRVEFSFKPE YSLFACESIL AGEENEYEDE YYGDYASDND LESADEDALE
SRYWDNEIYR WRSYSYNWQE RDNPCHPAYY NEDRIVQSNL MASDLGITVK AGNNGTYHVF
TNNLISSEPM GGVKVSLYNY QQQVIASRTT NAQGQIVFDT DNKAAFVVAQ KAANYAYARI
DDGMALSLSK FDVSGGQVQQ GLKGFLYTER GVHRPGDSIH LTFVLNDAAN PLPEDHPVKL
ELTDARGKLV ERRVVRGSVD GFYYFPLTTA AEAPTGNWNA TVKVGGASFG KTLRVATIKP
NRLKVQLEFE KAVLEADRPI SGALKSTWLH GAPARNLKAN VSLTLAESSS PFKDFTNFNF
NDPVRTFSTS EFNFLDADLN SEGAFGFKEQ LQLSDKAPGM LQASFVTKVY EGSGDFSIDV
INKPLAPYAH FVGLKPPKLG RYGSFETQRD HRFELVTVDA QGKASGNRKL TVEVFEISWR
WWWNRGRDNL SRYENSSVYR PVKTFEITTG SNGKGSFDLN IPDEQRGRYL IRVKDPVSGH
ATGMTTYFFK DWWQTGQAGS ESAKMLLFSS DKDTYNVGEQ AQIRFPSSAG STALISVENG
TEVLHYQWVK TQQGNTELSL DITPEMAPNV YINISLLQPH ERTKNDLPMR LYGVVPIMVN
NPKTELSPQL QIPSELKPET DYQVTVSESN GKAMTYTLAV VDEGLLDLTR FSTPDIHKAF
YARQALGVKT FDIYDLVMGA FSTQVDNFYA IGGGDAAAGA KNRKADRFKP VVSYLGPFKL
DPGQSATHTL TMPNYIGSVK TMVVAGYNQT QAYGKTEVVT PVRTPLMVLA SVPRKLSPGE
KLTLPVTVFA MDPKVKQAQV SIETSSGLKP TGSATKTVRF DSPGEQIVNF EYEIQASDAV
QNIKVLAQSG SHKASYPLEI DIYNPNPISR TSKTYTVEAG TQKQIDFATF GTAGTNKVTL
ELSTIPPMDL EKRLDYLIQY PHGCVEQTTS GAFPQLYLKD LVALSSTQAR RTEENIKAAI
RRLGQFQNTS GGMGYWMGES QSSDWGTSYA GHFLLEAKQQ GYTLPIGFLS NWTRYQRLAA
KQWRKSSQSY NTTHAQAYRL YTLALAGQPE LAAMNRLRKS GGLTNAALWR LAGAYALTGN
KSAALELLEK ATLKFENQRY SWYTYGSALR NMAMALEIMT LLQDENEREM ALSIAAQLSS
ERWLNTQETA YSLLALGKMV KINGGKSFSV SLNQNGQTTA LSSEKSILLQ ELSFVMGDNS
ISLNNTGESR IYASLIQQGR YPMWAEKAAT KNLSLRTDFL DKEGKRIDVA ELRQGTEFNI
RINILNNSND DLRDLSLTQL VPSGWEIVNT NFTAAVQGHV NPARYTDIRD DKVNYYFDLR
SGKSKTFELV VNASYLGRYY LAGTHSSTMY SDNYYARTQG QWVTVKQ
//
