ID A0A1Y1CGN4_9BACT Unreviewed; 748 AA.
AC A0A1Y1CGN4;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=GTP pyrophosphokinase {ECO:0000313|EMBL:BAX79243.1};
GN ORFNames=ALGA_0854 {ECO:0000313|EMBL:BAX79243.1};
OS Labilibaculum antarcticum.
OC Bacteria; Bacteroidota; Bacteroidia; Marinilabiliales; Marinifilaceae;
OC Labilibaculum.
OX NCBI_TaxID=1717717 {ECO:0000313|EMBL:BAX79243.1, ECO:0000313|Proteomes:UP000218267};
RN [1] {ECO:0000313|Proteomes:UP000218267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SPP2 {ECO:0000313|Proteomes:UP000218267};
RA Watanabe M., Kojima H., Fukui M.;
RT "Complete genome sequence of Marinifilaceae bacterium strain SPP2, isolated
RT from the Antarctic marine sediment.";
RL Mar. Genomics 0:0-0(2017).
RN [2] {ECO:0000313|EMBL:BAX79243.1, ECO:0000313|Proteomes:UP000218267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SPP2 {ECO:0000313|EMBL:BAX79243.1,
RC ECO:0000313|Proteomes:UP000218267};
RA Watanabe M., Kojima H., Fukui M.;
RT "Complete genome sequence of Marinifilaceae bacterium strain SPP2, isolated
RT from the Antarctic marine sediment.";
RL Mar. Genomics 39:1-2(2018).
RN [3] {ECO:0000313|Proteomes:UP000218267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SPP2 {ECO:0000313|Proteomes:UP000218267};
RA Watanabe M., Kojima H., Fukui M.;
RT "Labilibaculum antarcticum sp. nov., a novel facultative anaerobic,
RT psychrotorelant bacterium isolated from marine sediment of Antarctica.";
RL Antonie Van Leeuwenhoek 113:349-355(2020).
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
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DR EMBL; AP018042; BAX79243.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y1CGN4; -.
DR KEGG; mbas:ALGA_0854; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000218267; Chromosome.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:BAX79243.1};
KW Transferase {ECO:0000313|EMBL:BAX79243.1}.
FT DOMAIN 57..156
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 401..462
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
SQ SEQUENCE 748 AA; 86113 MW; 96A12136203B9615 CRC64;
MSGETEKDKQ LILDAYEELL KHCKRSREAE SKQIIDKAFH FAWEAHKGVR RKSGEPYILH
PISVAQIVAK EMSLGTKSIV AALLHDVVED TEYTLDDIQN HFGEKIAQIV DGLTKISDVF
DQQTSMQAEN FRKMLLTLSD DLRVILIKMA DRLHNMRTLN SMPLRKQMKI AGETLFLFAP
LAHRMGLYAI KSELEDLSLK YEHPDDFENI SKKIVEQEER QLKIIRKIIA PIKAKLKEAD
IKCTIKNRPR SIFSIWNKIE TQNKSIEEIY DLISVRVVFK PDPNISEKNQ CWNIYSLITD
IYKPKPERIR DWVSTPKANG YQALHVTAMG PQGDWIEFQI RTEKMDDIAE KGFAVHSKYN
TSGSGESELD KWLTDVREIL DNPEADAMAF LDEFKLNLFS KEIQVFTPKG HIRTLPKKAT
ILDFAYDIHT DIGNHCIGAK VNHRLVPLSH ELKSGDQVEI LTSEKQVPKY EWIEFVITAR
AKSKIKSAFK RERKEYTFKG VRMIEDQLLD SGLKLNANAF RKMLEYYKLS NKEELFYKVG
LGKIDINEID GVVRKKSKSK FIKYWKLQFF GDSKGNNEKE VLEIPDTKPE LDKKKTLMLT
ELATNESYKI ATCCKPIPGD EVLGYLDMAN NVTIHKRKCP NALKLMSSQG DRILAADWTS
HRLMSFLAII ELTGIDKIGI VNEVTNVISK DHDVNMRSLH FESHDGVFEG LIHLYVHNTE
DLNNLILKLI KVKGLDNVKR IENIEEYS
//
