ID A0A1Y1HIV6_KLENI Unreviewed; 378 AA.
AC A0A1Y1HIV6;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Nucleoside diphosphate kinase {ECO:0000256|RuleBase:RU004013};
DE EC=2.7.4.6 {ECO:0000256|RuleBase:RU004013};
GN ORFNames=KFL_000040250 {ECO:0000313|EMBL:GAQ77823.1};
OS Klebsormidium nitens (Green alga) (Ulothrix nitens).
OC Eukaryota; Viridiplantae; Streptophyta; Klebsormidiophyceae;
OC Klebsormidiales; Klebsormidiaceae; Klebsormidium.
OX NCBI_TaxID=105231 {ECO:0000313|EMBL:GAQ77823.1, ECO:0000313|Proteomes:UP000054558};
RN [1] {ECO:0000313|EMBL:GAQ77823.1, ECO:0000313|Proteomes:UP000054558}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIES-2285 {ECO:0000313|EMBL:GAQ77823.1,
RC ECO:0000313|Proteomes:UP000054558};
RX PubMed=24865297; DOI=10.1038/ncomms4978;
RA Hori K., Maruyama F., Fujisawa T., Togashi T., Yamamoto N., Seo M.,
RA Sato S., Yamada T., Mori H., Tajima N., Moriyama T., Ikeuchi M.,
RA Watanabe M., Wada H., Kobayashi K., Saito M., Masuda T.,
RA Sasaki-Sekimoto Y., Mashiguchi K., Awai K., Shimojima M., Masuda S.,
RA Iwai M., Nobusawa T., Narise T., Kondo S., Saito H., Sato R., Murakawa M.,
RA Ihara Y., Oshima-Yamada Y., Ohtaka K., Satoh M., Sonobe K., Ishii M.,
RA Ohtani R., Kanamori-Sato M., Honoki R., Miyazaki D., Mochizuki H.,
RA Umetsu J., Higashi K., Shibata D., Kamiya Y., Sato N., Nakamura Y.,
RA Tabata S., Ida S., Kurokawa K., Ohta H.;
RT "Klebsormidium flaccidum genome reveals primary factors for plant
RT terrestrial adaptation.";
RL Nat. Commun. 5:3978-3978(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-
CC deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316,
CC ChEBI:CHEBI:456216; EC=2.7.4.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000082,
CC ECO:0000256|RuleBase:RU004013};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-
CC triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000937};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000256|ARBA:ARBA00004430}.
CC -!- SIMILARITY: Belongs to the NDK family. {ECO:0000256|RuleBase:RU004011}.
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DR EMBL; DF236953; GAQ77823.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y1HIV6; -.
DR STRING; 105231.A0A1Y1HIV6; -.
DR OrthoDB; 5471350at2759; -.
DR Proteomes; UP000054558; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004550; F:nucleoside diphosphate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
DR GO; GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006228; P:UTP biosynthetic process; IEA:InterPro.
DR CDD; cd04412; NDPk7B; 1.
DR Gene3D; 2.30.29.170; -; 1.
DR Gene3D; 3.30.70.141; Nucleoside diphosphate kinase-like domain; 2.
DR InterPro; IPR006602; DM10_dom.
DR InterPro; IPR034907; NDK-like_dom.
DR InterPro; IPR036850; NDK-like_dom_sf.
DR InterPro; IPR011410; NDPK7.
DR InterPro; IPR037993; NDPk7B.
DR InterPro; IPR001564; Nucleoside_diP_kinase.
DR InterPro; IPR023005; Nucleoside_diP_kinase_AS.
DR PANTHER; PTHR43109; NUCLEOSIDE DIPHOSPHATE KINASE 7; 1.
DR PANTHER; PTHR43109:SF2; NUCLEOSIDE DIPHOSPHATE KINASE 7; 1.
DR Pfam; PF00334; NDK; 2.
DR PIRSF; PIRSF036503; NDK7; 1.
DR PRINTS; PR01243; NUCDPKINASE.
DR SMART; SM00676; DM10; 1.
DR SMART; SM00562; NDK; 2.
DR SUPFAM; SSF54919; Nucleoside diphosphate kinase, NDK; 2.
DR PROSITE; PS51336; DM10; 1.
DR PROSITE; PS00469; NDP_KINASES; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR036503-51,
KW ECO:0000256|RuleBase:RU004013}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000256|RuleBase:RU004013, ECO:0000313|EMBL:GAQ77823.1};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR036503-51,
KW ECO:0000256|RuleBase:RU004013};
KW Reference proteome {ECO:0000313|Proteomes:UP000054558};
KW Transferase {ECO:0000256|RuleBase:RU004013}.
FT DOMAIN 5..93
FT /note="DM10"
FT /evidence="ECO:0000259|PROSITE:PS51336"
FT ACT_SITE 208
FT /note="Pros-phosphohistidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR036503-50"
FT BINDING 101
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR036503-51"
FT BINDING 147
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR036503-51"
FT BINDING 195
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR036503-51"
FT BINDING 205
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR036503-51"
SQ SEQUENCE 378 AA; 42561 MW; 9A94E0653F090D5B CRC64;
MVDSNMDHLA FIVHWLDVQA GVTWKYQLTY HASDKSLEMY DIKNRRTFLK RTEYPSVKPE
HLYIGSIITV YSRQLHLMDY ADEHTRKKLD QKRETTLAMI KPDAIEHIGK ILNAIYGSGF
LIKRMKMCHL SLTEAQQFYA VHQARPFFRT LTEFMSSGRV FAMELVTENA IAKWRKLIGP
TNSDTARAED PDSLRANFGT DNTMNACHGS DAPETAKQEV SFFFDRADVG RCAQLRDCSL
AIVKPHAVTA GHAGAIIDQI AAHFEITALQ QHILDQANAV EFLEVYKGVV PEYNGLVDEL
KSGPLIALEV TSRDGSPDVV QELREFCGPA DPEIGKVLRP QSLRAQFGID KVKNAVHCTD
LPEDGPLESN FFFDILLS
//