ID A0A1Y1HRW3_KLENI Unreviewed; 623 AA.
AC A0A1Y1HRW3;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Protein DETOXIFICATION {ECO:0000256|RuleBase:RU004914};
DE AltName: Full=Multidrug and toxic compound extrusion protein {ECO:0000256|RuleBase:RU004914};
GN ORFNames=KFL_000280210 {ECO:0000313|EMBL:GAQ79316.1};
OS Klebsormidium nitens (Green alga) (Ulothrix nitens).
OC Eukaryota; Viridiplantae; Streptophyta; Klebsormidiophyceae;
OC Klebsormidiales; Klebsormidiaceae; Klebsormidium.
OX NCBI_TaxID=105231 {ECO:0000313|EMBL:GAQ79316.1, ECO:0000313|Proteomes:UP000054558};
RN [1] {ECO:0000313|EMBL:GAQ79316.1, ECO:0000313|Proteomes:UP000054558}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIES-2285 {ECO:0000313|EMBL:GAQ79316.1,
RC ECO:0000313|Proteomes:UP000054558};
RX PubMed=24865297; DOI=10.1038/ncomms4978;
RA Hori K., Maruyama F., Fujisawa T., Togashi T., Yamamoto N., Seo M.,
RA Sato S., Yamada T., Mori H., Tajima N., Moriyama T., Ikeuchi M.,
RA Watanabe M., Wada H., Kobayashi K., Saito M., Masuda T.,
RA Sasaki-Sekimoto Y., Mashiguchi K., Awai K., Shimojima M., Masuda S.,
RA Iwai M., Nobusawa T., Narise T., Kondo S., Saito H., Sato R., Murakawa M.,
RA Ihara Y., Oshima-Yamada Y., Ohtaka K., Satoh M., Sonobe K., Ishii M.,
RA Ohtani R., Kanamori-Sato M., Honoki R., Miyazaki D., Mochizuki H.,
RA Umetsu J., Higashi K., Shibata D., Kamiya Y., Sato N., Nakamura Y.,
RA Tabata S., Ida S., Kurokawa K., Ohta H.;
RT "Klebsormidium flaccidum genome reveals primary factors for plant
RT terrestrial adaptation.";
RL Nat. Commun. 5:3978-3978(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199,
CC ECO:0000256|RuleBase:RU004914}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU004914}.
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DR EMBL; DF236977; GAQ79316.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y1HRW3; -.
DR OrthoDB; 296207at2759; -.
DR Proteomes; UP000054558; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR CDD; cd13136; MATE_DinF_like; 1.
DR InterPro; IPR044644; DinF-like.
DR InterPro; IPR002528; MATE_fam.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR42893; PROTEIN DETOXIFICATION 44, CHLOROPLASTIC-RELATED; 1.
DR PANTHER; PTHR42893:SF9; PROTEIN DETOXIFICATION 46, CHLOROPLASTIC; 1.
DR Pfam; PF01554; MatE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|RuleBase:RU004914};
KW Reference proteome {ECO:0000313|Proteomes:UP000054558};
KW Transmembrane {ECO:0000256|RuleBase:RU004914};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004914}.
FT TRANSMEM 226..245
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 257..279
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 354..375
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 396..419
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 439..460
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 481..504
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 547..567
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 623 AA; 65909 MW; DBB26BA6A08B436E CRC64;
MQGSASVDRR QSALRCSPDS PSDSVIEAPP PRSRPEAPTL QPPFDTFDNV PAFDSPLPET
HDGVSSFDSP GLTPDAHIPP FEDTVRLGRV VNTPGLDDPS LAPDYNIKDG TNREGTAEAS
PAVIKDRFSR GVEEPLRAED DISRVPASQA VAAAKPAVLE SPVEEDLLDQ GDLWEQAKRI
MAFAGPALGI WLGNPTMSLV DTAVIGTASS LELAALGPGT ALSDGFGHLF MFLSVATSNL
IATSLAEKDP EGAARSLSRA LFIALVCGFG ITAICETLHT PLLKAFVGKN VGLIPAARVY
VQIRGLAWPA VLVTMVAQSA CLGMQDAWGP LRVLVVAASI NCLGDILLCS VLKMGIAGAA
WATAASQIVG CVLMLQSLRK RSTIPLYLSV PRFADLVTFM SIAGPTLVTM FSKVSFYTLM
TYVCTANGTA TGAGHQVMIG LYAFFAVFGE PLCQTAQSFI PEFIRGANRS LHKARKLLQS
LVLMGGLQGL VLGAGAGLMP WVLPQLFSND AAVIDQMRRV SVQIFIAVVL TPVNLSMEGT
LLAGRDLVYL AISMVCSFSI MASALLVGSK RGIGLGGIWW CLVGFQSIRF VSASMRLSNP
KSVVGGLRTR RTSPEPIPVV MGK
//
