ID A0A1Y1HZV8_KLENI Unreviewed; 4079 AA.
AC A0A1Y1HZV8;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Dyneins heavy chain {ECO:0000313|EMBL:GAQ82709.1};
GN ORFNames=KFL_001210030 {ECO:0000313|EMBL:GAQ82709.1};
OS Klebsormidium nitens (Green alga) (Ulothrix nitens).
OC Eukaryota; Viridiplantae; Streptophyta; Klebsormidiophyceae;
OC Klebsormidiales; Klebsormidiaceae; Klebsormidium.
OX NCBI_TaxID=105231 {ECO:0000313|EMBL:GAQ82709.1, ECO:0000313|Proteomes:UP000054558};
RN [1] {ECO:0000313|EMBL:GAQ82709.1, ECO:0000313|Proteomes:UP000054558}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIES-2285 {ECO:0000313|EMBL:GAQ82709.1,
RC ECO:0000313|Proteomes:UP000054558};
RX PubMed=24865297; DOI=10.1038/ncomms4978;
RA Hori K., Maruyama F., Fujisawa T., Togashi T., Yamamoto N., Seo M.,
RA Sato S., Yamada T., Mori H., Tajima N., Moriyama T., Ikeuchi M.,
RA Watanabe M., Wada H., Kobayashi K., Saito M., Masuda T.,
RA Sasaki-Sekimoto Y., Mashiguchi K., Awai K., Shimojima M., Masuda S.,
RA Iwai M., Nobusawa T., Narise T., Kondo S., Saito H., Sato R., Murakawa M.,
RA Ihara Y., Oshima-Yamada Y., Ohtaka K., Satoh M., Sonobe K., Ishii M.,
RA Ohtani R., Kanamori-Sato M., Honoki R., Miyazaki D., Mochizuki H.,
RA Umetsu J., Higashi K., Shibata D., Kamiya Y., Sato N., Nakamura Y.,
RA Tabata S., Ida S., Kurokawa K., Ohta H.;
RT "Klebsormidium flaccidum genome reveals primary factors for plant
RT terrestrial adaptation.";
RL Nat. Commun. 5:3978-3978(2014).
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm, cytoskeleton, flagellum
CC axoneme {ECO:0000256|ARBA:ARBA00004611}.
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DR EMBL; DF237070; GAQ82709.1; -; Genomic_DNA.
DR STRING; 105231.A0A1Y1HZV8; -.
DR OrthoDB; 312288at2759; -.
DR Proteomes; UP000054558; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF28; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054558}.
FT DOMAIN 837..1240
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1369..1695
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1860..1989
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2210..2290
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2353..2613
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2627..2986
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3016..3236
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3481..3594
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3626..3765
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3771..4075
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 48..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 796..823
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2878..2933
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3184..3211
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4079 AA; 460659 MW; D61F7D508275AB1C CRC64;
MAPTAEAVAV RPISATNQKG QAGLLNREPI ISDGTHGVVG TNGATKVDAS AELQPAKESP
QGMQGERNRR LFEMQDILTL LANEGVNPQD LSPPDPRSSD PGAPKLALSH FDNTDFETRL
GGGWVNKASE VPAEAAHVDR ETKAVTWRPC KVLDYREGGN AYEVQWEGGE ERVWLPRIHV
HFQAEDPFLF AKRVAEAHQL RKRAESLLRY NLYVDSMPTD DIPGLSPEQI SRMLACSTNS
KRLREWAFDS SQLVAEVNLD YARAMNKIIF DESVRKRPRS RDVMFMPVDE EFPIDPRPPV
PQFGCVQIPR YAFPEQLSEF VFHTCLSRPE VISATVKIRA ECNKVAKMSL FSTTHTKSSR
MDEFEQVQVQ ACDAVATYLK DSWVSTIKGI IRSSFKDVGK GWFSLQGQSQ DTYFGSKLHR
FLLMVRFLME DNLKCMVDES LAKYVDHMDR NCNPLVDVRG VDDVAVTWQS DDAARSRKPP
LFALELLSTD AGAFDYNTPV SLFEQMIGKT FDHGVTACQS VPQIEPQIMD NLFWSHKPMV
NSPQLLEPHV ITLKGRLASG VKRALTAVRV YLDKWVEFEP LLRLDPAEYR TGLEQRNAPL
KELQAEIDRH QADLLDLDRR LPSQINVGAF QVTTKKMRAQ LLQKKEQLSA LVTELICKVP
RATCQDLDRR FLEIEKQLKM KTTTPEDVAA QKEYIASLPQ KLGELQGEIN GSQVYYDALD
SLCYTLSESD YNQKWACAAW PARIAKQIEK TEGTLEGDQT SYEKDMRGEQ EAFAVALGDL
ETRVQGFERH VDLAQVDHVA AELRQLTEAL DKADKDARLF NSREALFGAQ PTDYSRLKRA
QEAFDPFSQL WTIAADWKRG RAAWADDPLE TLNPEEIEKS TLAWWKALFK VGKVFQNKGL
AECAANCDDI RAQLDAFKPQ VPLIAALRQA GMRDRHWQQI SEELGVPIVI DNTFTVTKAI
GMGLPQHLGV ISKVADVAGK EYAIETALDK MQNEWKTIEL QVLEYRETGT YVIKVEEAVT
QQLDDHIVMT QSMSFSPFKK PFQERLAQWE SQLSLVSEVL DEWLALQRQW MYLEPIFSSE
DIQHQLPLEG KRFTTVDRIW RKALGQAKAT PHILTCCGSQ KLLENFRESN KMLDMVQKGL
ADYLETKRLA FSRFFFLSND ELLQILSQSK NPLAVQPHLR KCFEAISDLD FKEDLEITAM
NSGEREKVPF AKTMYPTGSV ENWLSEVERR MKESVREQAK LALEDYQTKA RAQWVQCWPA
MVVLAGSSIY WTRQVEEAIG KGTLKDYFEN VQVKQLLDLT DLVRGELPKL ARLTLGALIV
IDVHARDVVQ RLVDENIGAI TEFEWVSQLR YYWENDDVYV KMVQASLPYG YEYLGNSARL
VITPLTDRCY MTLMGALHLN LGGAPAGPAG TGKTETTKDL AKALAKQCVV FNCSDGLDYL
AMGKFFKGLA SSGAWACFDE FNRIDLEVLS VVAQQILTIQ LAIQQKLKRF VFEDSEISLD
PSCSVFITMN PGYAGRSELP DNLKALFRPC AMMVPNYDLI GEISLFSFGF RQAKNLARKM
VATFKLCSEQ LSSQDHYDYG MRAVKSVITA AGNLKRDYPD EDEEVLLLRG LRDVNVPKFL
SHDLPLFAGI ISDLFPGVQP PKIQYDDLLG ALTRACAQLG IQPVDSFMTK VIQLYETTLV
RHGLMLVGPT GGGKTMCYRA LAMAMTELNK DGSAKYEKVR TVVLNPKSIT MGQLYGEFDD
NTHEWTDGVL ACYMRELSED TSTAKKWLMF DGPVDAVWIE NMNTVLDDNK KLCLVSGEII
QLSSTMTMMF EVEDLAVASP ATVSRCGMVY MEPTAMGLDP LLDSWLQALP EPCKPFGARL
RALFEKLVAP TLRLVRKSLR ETVATTNNNL VLSLFKLMDS LLLTWRRQEN EPKLTEEEIG
KLPNVIEQLF IFSLVWSVGA SCDNDGRVKF DRALRDACSE AGVDKLPPGD RDVYAYCFNQ
DTCQWVDWMA TIPEFKCDPD RPFSEIIVPT SDTVRYTYVI DQLLRNNCHV LCVGETGTGK
TLNVADKLLN KMGADTVPLF LTFSARTSAN QTQDLIDSKM EKRRKGVFGP PSGKKFVVFV
DDMNMPQREK YFAQPPIEIL RQWMDHKGWY ERKPPCTFRQ LIDIQFVGCM GPPGGGRNPV
TNRFLRHFNF ISFTEMSNES VDRIFSTILG ATLERRFDPT VQGVKGPVVA GTIEIYNRIR
KELLPTPSKS HYTFNLRDLS KVIQGVLRAD PKQVTDPKSL LSLWLHEAQR VFQDRLINDE
DRAWFRRALE EQLAQQCALT WADVVTADRL IYGDYLVPGA EPKVYQQVTD TKKLVSTMEE
YLDDYNSVSQ APMKLVMFLD AIEHVSRICR VIRLPLGNAL LLGVGGSGRQ SLTRLATYME
DFHLFQIEIA KGYGPNEWRE DLKRVLMKAG LEGKETTFLF TDTQIVVESF LEDINNILNS
GEVPNLWKTE DTEAIANGMR PIMQQLGLPI TKMALQTQFI RRVRSNLHLV ICMSPIGDAF
RTRLRMFPSL VNCCTIDWFS EWPNEALKSV AHSFFSDAVQ MASPEQTSAI VDTCVFIHQS
VERTSKDFFE ELRRYNYVTP TSYLELLTTF IKLVSEKRAE IEQLRSRLSI GLDKLLSTAA
QVEVMQKELT ELQPVLVVTA KEVEDMMVTI TADKASADAT KQQVAVQEAE ATAQATEAKG
IADSAQRDLD QALPALDAAV ASLKNLTRND IVEVKSLRNP PEGVKLVMEA CCIMFQQQPK
MVADPNKVGK KMADYWEPST KMLNDPTKFL DSLLTFDKDN IPEAVIQKIE PYIGMENFTP
EQVKRVSTAC TSIGISVKRV STACTSICMW VRAMHTYYNV AKSVAPKRAQ LAEANAKLEV
TMGQLRVAQA TLKEVEDRIA GLEAQLAAAV AKKDELAKQA SDCTVKLERA EKLIGGLGGE
KLRWTESVKN LTAQLDSVVG DVVVASGAIA YLGPFTPNYR SRLQEEWLAR LKELSVPHTA
GADLKGVLQD PVLVRMWNIA GLPSDDASIE NGIIVSKARR WPLFIDPQGQ ANKWIKAMFK
ETGLDVIKLS DKDFLRTLEN GVRFGRAVLL ENILETLEPA LEPLLLKQTF KQGGSEVIKI
GDNIIPYHPD FRFYMTTKLR NPHYPPEVSV KVSLLNFFVT PEGLEDQLLG QVVTQERPDL
AEMKNQLVLS NASMKKELKE IEDKILQLLS NSQGNILDDE VLINTLAKSK VTSNEIAVKV
AEAEKTEKEI DVTREVYRPV ALRASLLFFC ISDLATVDPM YQYSLAWFIN LFIKCIDEAP
KAETVEERIG VLNEHFMYSL YVNVCRSLFE KHKLMFSLML TVKILQERNE VDPAEWRFLL
AGATDSTLDR PNPAPEWLTE KAWVEILNLS KLERFKGFQT HVAAHVRHYK AYFDSSDAHR
EKLAGEWEEK LTRLQKLLVV RCFRVDKAMV AIQDFVAATL GQRFIEPPPF NLQACYKDSS
PTAPLIFVLS SGADPMADLL QLADEMRFTK KFEKVSLGQG QGPKAEKLLQ MGMERGMWVC
LQNCHLSQSW MPSLERIVEN IDPEKVHKDF RLWLTSMPSP AFPVAILQNG VKMTLEPPKG
MKSNLMRSYL RFNDKYLNDC EKPVEWRKLL FGLCLFHAVI QERRKFGPLG WNIRYEFTEG
DLGVCQTQIR MFLNEYKDIP YKVIRFLCGE INYGGRVTDD KDRRLINNLL LTFINPGVVA
EQPYSFSESG VFRISAAGDL TGFLDYIKEL PLAPKPEIFG LHENADITCD QNESLDLFAT
VLSLQPRTTG KAGGGLSRDE LVEKVCTDIL TKVPPVFDVE AVLQAYPTSY KESMNTVLTQ
ECIRYNGLLA VMKKSLQDAL KALKGLVVMS PDLEQLCTSI FNNQVPEMWA AKAYPSLKPL
SSWVADLLER CAFISNWIAK GSPAVYWISG FFFPQAFLTG TLQNYARKYG YPIDTVSFNF
VVCDEKTLES TGDPPEDGCY IRGLYLEGAR WDSRRHLLGE SNPKELYSEM PIVWLSPVQN
RKPPKTGVYE CPVYKTLLRA GTLSTTGHST NFVMYIEIPT DKEQAHWINR GVGLFTSLT
//
