ID A0A1Y1JHV3_PLAGO Unreviewed; 504 AA.
AC A0A1Y1JHV3;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Cysteine proteinase gondepain 2 {ECO:0000313|EMBL:GAW80925.1};
GN ORFNames=PGO_091240 {ECO:0000313|EMBL:GAW80925.1};
OS Plasmodium gonderi.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=77519 {ECO:0000313|EMBL:GAW80925.1, ECO:0000313|Proteomes:UP000195521};
RN [1] {ECO:0000313|Proteomes:UP000195521}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 30045 {ECO:0000313|Proteomes:UP000195521};
RA Arisue N., Honma H., Kawai S., Tougan T., Tanabe K., Horii T.;
RT "Plasmodium gonderi genome.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAW80925.1}.
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DR EMBL; BDQF01000010; GAW80925.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y1JHV3; -.
DR EnsemblProtists; GAW80925; GAW80925; PGO_091240.
DR OMA; NGYRKPC; -.
DR OrthoDB; 808912at2759; -.
DR Proteomes; UP000195521; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 1.10.287.2250; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF1017; CLAN CA, FAMILY C1, CATHEPSIN L OR K-LIKE CYSTEINE PEPTIDASE; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000195521};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT TRANSMEM 36..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 183..241
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 281..502
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 504 AA; 57505 MW; E55D3B9281E306C8 CRC64;
MEYHVEYSSS RSGKIENESF VHKPLMETGV KRNKNIFIAL SVSTVCLLGG CAIYYSRTQK
ENYNPVYGNS LDEQSSDDSI INSFLNSESG KKFIASKLSE YLASYGKTAD TSEDMQDSNF
GYEQHIDGTE IPSINKESVK DGGRAEEHYK NRFGNLKVTQ RNDIINLADP KFLMANLESV
NAFYLFVKEY KKNYTTADEM QEGFIAFLDN LKKIQTHNQS KKKSLYRKGM NKFGDLTFEQ
FQKKYLTLKT FDLKKNENNI KGLVTYDEVI KKYKPDDATF DRAAYDWRLH KGVTPVKDQG
NCGSCWAFSA VGVVESQYAI RKNEIVSISE QQLVDCSKNN LGCNGGLIPL AFEDMVEMGS
LCSIMDYPYY AVDTDVCKKD TCKKKYKVNN FLEIPEFKFK EAIRYIGPIS VSIAVCDDFT
FYQGGIFDVD CGNKPNHAVI IVGFGVEEIY DEDTQMNKKH YYYIIKNSWG MDWGEKGFMR
FETDLNGYRR QCALGDEAMA ALVD
//
