ID A0A1Y1JJ66_PLAGO Unreviewed; 2294 AA.
AC A0A1Y1JJ66;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Histone deacetylase 2 {ECO:0000313|EMBL:GAW80503.1};
GN ORFNames=PGO_080670 {ECO:0000313|EMBL:GAW80503.1};
OS Plasmodium gonderi.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=77519 {ECO:0000313|EMBL:GAW80503.1, ECO:0000313|Proteomes:UP000195521};
RN [1] {ECO:0000313|Proteomes:UP000195521}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 30045 {ECO:0000313|Proteomes:UP000195521};
RA Arisue N., Honma H., Kawai S., Tougan T., Tanabe K., Horii T.;
RT "Plasmodium gonderi genome.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the inositol phosphokinase (IPK) family.
CC {ECO:0000256|ARBA:ARBA00007374}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAW80503.1}.
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DR EMBL; BDQF01000009; GAW80503.1; -; Genomic_DNA.
DR EnsemblProtists; GAW80503; GAW80503; PGO_080670.
DR OMA; AWLYLCC; -.
DR OrthoDB; 124800at2759; -.
DR Proteomes; UP000195521; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0032958; P:inositol phosphate biosynthetic process; IEA:InterPro.
DR CDD; cd09992; HDAC_classII; 1.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 3.
DR Gene3D; 3.30.470.160; Inositol polyphosphate kinase; 1.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR005522; IPK.
DR InterPro; IPR038286; IPK_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF4; HISTONE DEACETYLASE 6, ISOFORM G; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 3.
DR Pfam; PF03770; IPK; 1.
DR PRINTS; PR01270; HDASUPER.
DR SUPFAM; SSF52768; Arginase/deacetylase; 2.
DR SUPFAM; SSF56104; SAICAR synthase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000195521};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 505..607
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT DOMAIN 787..898
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT DOMAIN 1050..1173
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT REGION 80..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 901..1040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1366..1390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1918..1951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..948
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..994
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1008..1025
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1026..1040
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1371..1390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1918..1942
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2294 AA; 265478 MW; 276ED9C17F838B69 CRC64;
MKNETTYNEN ISDNKQSSLK QDTIARLKLP DKRAYFNNFI IEKFNSISDI SLYLRGTNNI
DENANEEEQD DLYLGGYNTV ANDDHERSPN LRSANGRSNR IGDKRMRGGR MRSGSVRSDS
VITSSIRRDR VRSRNVRSNS MRSSIVGNKK NSDMNRITSN HVSDNHVISN RISSNHISSN
HISSNHISNN RVRRSLDSYP QVTVNRSFSS PSLTKRSWSD QTSSNSKRKK LESNAEGRRQ
KKLETKNTSR KKNNTGRGKE HKKRRSRSDI SQGDRRKKKK KKSNEKREIR NVKQGLGIRN
NIINKNTSKG KNKVVNNFSI RKNRQMKRSQ HSSTSSNNDD EFNANKRILD KIFLSLKRKG
NTNEYINNSF YIECDDILEI DSDMEEDTDV EPSIHDAPDG GPNTYAEAIV PYNPVKPNKN
LHLTEEDFYS ISKSSSKMNK EREAIDNFYK YKPIQHRKNH DLSEVKNGKI FSSPKNCNQS
VEYDCIGFVC DEEYMCQNLH FDENHVESPD RIKCIIKILK EKNVINKMVQ IKCREALFEE
IKECHSTSHI NNIFYSLKRI LKYKKKDVIY PFDKHDTYYT SYTGTVSKRA VGGLLNLCDA
ILSNKNEKFK YIDFKKSFRY NYNFFKNIPP SSVRRYMGNK INHYNHLKRS KSESNLHVMH
HFQHNDSNHH LDFDIPYKGN NSNIKCDKYK QQSNIPFKKI NNKTVSTSNY CYNSNQAYDM
ITPNENISIP HKNNKEESVL RLCEVSSPQK QKSLIDEAIS SINQPTDDVE LDDNVSKNTC
ADNNPSNKEE FPVFNKLYRS YSTTMCNVKE CTNNSNSFTD INCGFAAIRP PGHHCSRNNP
SGFCIFNNIS VACKYIFKKY GIRKIFIFDW DVHHDNGTQE IFYNDKDVLC FSIHRFDKKK
SKGQKRKSRR CLNTLGGKTS NGEKGKNRDG SDDNGKSIRN RKGENNKSGS KGFKVSSNGN
AKSGTIPDDG TSEVNGELTC SSSSDSSNGI INKSLNSEKK KEKTQKRNMN MNTSMSTNTS
SKMNAKTKTM RKKKPKTNRK YKRNLRSYEE NLFYPRTGAK SELGSKNGYK FNINVPLEKG
YNNCDVYYVF KYLLLPILEN FQPEFIFISC GFDASINDPL GECNLTHNFY QWMTLQLKHF
ANIFCKGRII LVLEGGYNLN YLPKCTLACI KALIKKNKNR KMQYQIAHES DTTAQLAKDE
RTTTEGALEK VSNVSQSKKE IISNGNNTNK SNEVVNKNAA DNSKDSIFKK MEDWRQVKHG
NLINNSNKEC DHINFYKFKN NTWHNKNSYE QFKHSGGKTY TTNITSKKKE LITAGKLHYS
TYKVIKYFLC ILKGDPFHLN IKLPPYNTFM KKKGFENKKI SRDRTINIYS RSNDRNDNSP
QGDSYSNNED GNCVVDQYGK NCYHHEDTLI EGEENSGGAL LNFYVNENEK EYNKYHQENM
KQYPQSSTTM SNLSNSDLYI SNDELEQHSQ SSDSSMNNRR KVIMLNKLKL KLNKSSNMMN
NSPTGYSSSI SKMTKKRKKQ KNNFHVSADK NKNMKEIDIW NHSEIPKENN NIEEVSDKNS
NENDTIDNCV RDQRVEEEDA LNMQHSTSMN HTPNMEQLSI ILQETDENDS HLNCDLTNLK
YCKDQLQNSF TMYTKRKKGF IFFYCSGHRN QWVLPIHKKI MRIIKLCSEL EAYFYAWLYL
CCGKEICISE TMSDYSAVLE DKVRVNNLSL NVVFSEEQKK HAKEFIKFTV PCYYSFLRRN
QLFQLGYRKG ESYQLQCELE NEVQIMQMIN AVKTIKPVKE TNAGDHVEFL EGINETKENE
VVANHNKSFI EDSNIYPNDC TPDREEVKKE IDKNGDVIDI ADEVDVADKV DVNDNVNVAN
NMNVADVIDM TDENYDREKN NTNHENHKIN NSNKGIVHTL GNYEYGVVIV NSDEIHTNPS
ECDKNKSHDF SEHNDNEKNR IESKSSNPMN SNISIIKMDE EVLKKDKNIE LDQENGKLRL
KMNHSGKNLN GDEEKTAICL ANVLCRMRHP CVMDIKMGAR LYGDDCDEES IQKKIQKAKM
RSCLSHGFHL TSIIGWNKKK QEPFFTSKED AHSVKKDDDF VDIFKSYFLA CDNVHISILL
LKKLLLILEH MKNFFETQQF FVFYGASLLF VFDSDPSKNE NDLEGSIDVK GNITCEMSAA
TSDHLHTFEK FINGQERDIT EINNDNLDQN SMKEKKNKEE KFNKWKDEYY EDIFNFKEKI
QNIFEQSLTL EEKNIYMQSK LNSKILKSAT IYIIDFAHAN FNRNEKDDGF LLGITSLHRI
MRKTIEKIQS LYLI
//
