ID A0A1Y1NMP9_PHOPY Unreviewed; 304 AA.
AC A0A1Y1NMP9;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 13-SEP-2023, entry version 18.
DE RecName: Full=Thymidylate synthase {ECO:0000256|ARBA:ARBA00015931};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
GN ORFNames=PPYR_06939 {ECO:0000313|EMBL:KAB0799059.1};
OS Photinus pyralis (Common eastern firefly) (Lampyris pyralis).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia; Elateroidea;
OC Lampyridae; Lampyrinae; Photinus.
OX NCBI_TaxID=7054 {ECO:0000313|EMBL:JAV97227.1};
RN [1] {ECO:0000313|EMBL:JAV97227.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28004739; DOI=10.1038/srep38556;
RA Al-Wathiqui N., Fallon T.R., South A., Weng J.K., Lewis S.M.;
RT "Molecular characterization of firefly nuptial gifts: a multi-omics
RT approach sheds light on postcopulatory sexual selection.";
RL Sci. Rep. 6:38556-38556(2016).
RN [2] {ECO:0000313|EMBL:KAB0799059.1, ECO:0000313|Proteomes:UP000327044}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1611_PpyrPB1 {ECO:0000313|EMBL:KAB0799059.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KAB0799059.1};
RX PubMed=30324905;
RA Fallon T.R., Lower S.E., Chang C.H., Bessho-Uehara M., Martin G.J.,
RA Bewick A.J., Behringer M., Debat H.J., Wong I., Day J.C., Suvorov A.,
RA Silva C.J., Stanger-Hall K.F., Hall D.W., Schmitz R.J., Nelson D.R.,
RA Lewis S.M., Shigenobu S., Bybee S.M., Larracuente A.M., Oba Y., Weng J.K.;
RT "Firefly genomes illuminate parallel origins of bioluminescence in
RT beetles.";
RL Elife 7:e36495-e36495(2018).
RN [3] {ECO:0000313|EMBL:KAB0799059.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=1611_PpyrPB1 {ECO:0000313|EMBL:KAB0799059.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KAB0799059.1};
RG Photinus pyralis genome working group;
RA Fallon T.R., Sander Lower S.E., Weng J.-K.;
RL Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004992}.
CC -!- SIMILARITY: Belongs to the thymidylate synthase family.
CC {ECO:0000256|ARBA:ARBA00009972}.
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DR EMBL; GEZM01002485; JAV97227.1; -; Transcribed_RNA.
DR EMBL; VVIM01000005; KAB0799059.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y1NMP9; -.
DR InParanoid; A0A1Y1NMP9; -.
DR UniPathway; UPA00575; -.
DR Proteomes; UP000327044; Unassembled WGS sequence.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR HAMAP; MF_00008; Thymidy_synth_bact; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR InterPro; IPR020940; Thymidylate_synthase_AS.
DR NCBIfam; TIGR03284; thym_sym; 1.
DR PANTHER; PTHR11548:SF2; THYMIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
DR PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW Reference proteome {ECO:0000313|Proteomes:UP000327044};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 22..304
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
FT ACT_SITE 186
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10016"
SQ SEQUENCE 304 AA; 35014 MW; 046E820DE0F31D6C CRC64;
MDNLNGIVKN ETENKERHEE FQYLNHIRQI LDTGVKRSDR TGVGTYAIFG AQMRYSLRDN
IFPLLTTKRV FWRGVVEELL WFIRGSTNAK DLSDKKVHIW DANSSREFLD QMEFTDREVG
DLGPVYGFQW RHFGATYEGM HADYDGKGID QLKQVIDTIR NNPNDRRIIM CAWNPVDIPK
MALPPCHCLV QFYVANGELS CLLYQRAADM GLGVPFNIAS YSLLTVMIAH VTGLKPGEFI
HTLGDSHVYL THVEPLKEQL QRVPKPFPHL HIKRHVASID DFKVEDFDLV GYDPYPTIKM
EMAV
//
