ID A0A1Y1RHR2_9BACT Unreviewed; 646 AA.
AC A0A1Y1RHR2;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=transketolase {ECO:0000256|ARBA:ARBA00013152};
DE EC=2.2.1.1 {ECO:0000256|ARBA:ARBA00013152};
GN ORFNames=B6244_06625 {ECO:0000313|EMBL:OQY28621.1};
OS Candidatus Cloacimonetes bacterium 4572_55.
OC Bacteria; Candidatus Cloacimonadota.
OX NCBI_TaxID=1971726 {ECO:0000313|EMBL:OQY28621.1, ECO:0000313|Proteomes:UP000192623};
RN [1] {ECO:0000313|Proteomes:UP000192623}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Dombrowski N., Seitz K., Teske A., Baker B.;
RT "Novel pathways for hydrocarbon cycling and metabolic interdependencies in
RT hydrothermal sediment communities.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate =
CC aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate;
CC Xref=Rhea:RHEA:10508, ChEBI:CHEBI:57483, ChEBI:CHEBI:57737,
CC ChEBI:CHEBI:58273, ChEBI:CHEBI:59776; EC=2.2.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001027};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the transketolase family.
CC {ECO:0000256|ARBA:ARBA00007131}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OQY28621.1}.
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DR EMBL; NBMB01000020; OQY28621.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1Y1RHR2; -.
DR STRING; 1971726.B6244_06625; -.
DR Proteomes; UP000192623; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004802; F:transketolase activity; IEA:UniProtKB-EC.
DR CDD; cd07033; TPP_PYR_DXS_TK_like; 1.
DR CDD; cd02012; TPP_TK; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR005478; Transketolase_bac-like.
DR InterPro; IPR020826; Transketolase_BS.
DR InterPro; IPR033248; Transketolase_C.
DR InterPro; IPR033247; Transketolase_fam.
DR InterPro; IPR005474; Transketolase_N.
DR NCBIfam; TIGR00232; tktlase_bact; 1.
DR PANTHER; PTHR43522; TRANSKETOLASE; 1.
DR PANTHER; PTHR43522:SF2; TRANSKETOLASE 1-RELATED; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF02780; Transketolase_C; 1.
DR Pfam; PF00456; Transketolase_N; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
DR PROSITE; PS00802; TRANSKETOLASE_2; 1.
PE 3: Inferred from homology;
KW Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 336..507
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
FT REGION 233..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 646 AA; 70955 MW; DCF1C5A5B74741F8 CRC64;
MIEKSKSGHP GAAMALAPAA YLLYSRFLKH NPKNPDWLNR DRFILSCGHV SVLLYSTLHL
SGYSISLDDL KNFRQWRSIA AGHPEQGLAP GVETTSGPLG QGCAASVGMA IAETHLADRF
NTRDHTVVDH HTWVLCSDGD MMEGVSHEAA SLAGHLRLGK LIWIYDDNRV TIDGPTSISL
SDDTDKRFEA CGWHVQSVQD VNDLPLLAQA MSRAKNETQR PSLIRVRTHI GFGAPNKQDR
SAAHGSPLGS DETKATKIAY GWDSDEPFHI PTEISNHCLQ AISRGEQAEI DWLATLKQWR
TANPLLASEW DRTLLGDLPD NWDRDIPLFP PDEKGSGTRI SSWKILNAIA PHIPELIGGS
ADLAASVKSN MTKCRDFSAE NRGGRNLHFG IREHAMAAIL NGVSLHRGLR PFGSTFLVFS
DYMRPSIRLA ALMKLPVIYI WSHDAINIGE DGPTHQPVEH LAALRSIPGL TIIRPADANE
TVAAWRVIIK SRSGPVGLIL TRQNAPTLSE TMGKSEQGVA HGAYILSEPE GDGDLDAIII
ATGYEVHLAL AAQKKMQDHG TSVRVVSMPS WELFDLQSKD YRERVLPPNT RKLAIEAGVE
QGWWKYVGDK GDVLCLNRFG ASAPESVVYK KLGFHVDRVI GKITKT
//