ID   A0A1Y1RTR2_9SPIO        Unreviewed;       535 AA.
AC   A0A1Y1RTR2;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   SubName: Full=Mannitol dehydrogenase {ECO:0000313|EMBL:ORC31176.1};
GN   ORFNames=B4O97_17340 {ECO:0000313|EMBL:ORC31176.1};
OS   Marispirochaeta aestuarii.
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Spirochaetaceae;
OC   Marispirochaeta.
OX   NCBI_TaxID=1963862 {ECO:0000313|EMBL:ORC31176.1, ECO:0000313|Proteomes:UP000192343};
RN   [1] {ECO:0000313|EMBL:ORC31176.1, ECO:0000313|Proteomes:UP000192343}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JC444 {ECO:0000313|EMBL:ORC31176.1,
RC   ECO:0000313|Proteomes:UP000192343};
RA   Shivani Y., Subhash Y., Sasikala C., Ramana C.;
RT   "Draft Genome sequence of Marispirochaeta sp. strain JC444.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ORC31176.1}.
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DR   EMBL; MWQY01000026; ORC31176.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1Y1RTR2; -.
DR   STRING; 1963862.B4O97_17340; -.
DR   OrthoDB; 271711at2; -.
DR   Proteomes; UP000192343; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR000669; Mannitol_DH.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43362:SF1; MANNITOL DEHYDROGENASE 2-RELATED; 1.
DR   PANTHER; PTHR43362; MANNITOL DEHYDROGENASE DSF1-RELATED; 1.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   PRINTS; PR00084; MTLDHDRGNASE.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000192343}.
FT   DOMAIN          40..198
FT                   /note="Mannitol dehydrogenase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01232"
FT   DOMAIN          236..471
FT                   /note="Mannitol dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08125"
SQ   SEQUENCE   535 AA;  58987 MW;  B9B85F70002BA21B CRC64;
     MKLTLEGLTK DIPQWKAGGY QLPKYDIEKV RAATLASPVW VHFGSGNIAR GYLAMLQQRL
     LDAGHSDRGM IICSSWDEEV VDRVFRPHDN LNVAVSLHAD GSVDKQVLAS VAAYIKTNSE
     LPELLRIFEN PSLQMASLAA TEKAYSLRDA SGGYAPELAS ALEAPPRQPG HLMVLIAFLL
     YRRYLAGAAP LALVSMDNFS HNGLKLFSSV HEIAESWVKT GSVEKAFLEY IGDPARVSFP
     WSMIDRIVPK PSEQVREMLI DDGYESGDII TTARGSKATT FVNLEEAEYL VIEDSFPNGR
     PALDKAGVIF TDRDTVDKVE TMKVCTGLNP LHTTLAIFGC LLGYDRIYEE MKNPLLRRFV
     TRLAYDEGLP VAAHPGIIDP EEFVHEVLTK RFPNPFVPDM PQRIAWDTSQ KVPVRFGVTL
     KAYAARGADA LGGLVYIPLF IAGWLRYLLG VNDEGKPFEI SPDPLGPVLQ EKLAGISLGN
     SGPYTENLKP ILSDEKLFGI DLVESGLAEK ISVMFGEMVK GPGAVTRTLE KYCRE
//