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Database: UniProt
Entry: A0A1Y1SNZ5_9RHOB
LinkDB: A0A1Y1SNZ5_9RHOB
Original site: A0A1Y1SNZ5_9RHOB 
ID   A0A1Y1SNZ5_9RHOB        Unreviewed;       418 AA.
AC   A0A1Y1SNZ5;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   16-JAN-2019, entry version 6.
DE   RecName: Full=Phosphoribosylamine--glycine ligase {ECO:0000256|HAMAP-Rule:MF_00138};
DE            EC=6.3.4.13 {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=GARS {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Glycinamide ribonucleotide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
DE   AltName: Full=Phosphoribosylglycinamide synthetase {ECO:0000256|HAMAP-Rule:MF_00138};
GN   Name=purD {ECO:0000256|HAMAP-Rule:MF_00138};
GN   ORFNames=ATO13_16219 {ECO:0000313|EMBL:ORE92483.1};
OS   Stappia sp. 22II-S9-Z10.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Stappia.
OX   NCBI_TaxID=1317123 {ECO:0000313|EMBL:ORE92483.1, ECO:0000313|Proteomes:UP000192401};
RN   [1] {ECO:0000313|EMBL:ORE92483.1, ECO:0000313|Proteomes:UP000192401}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=22II-S9-Z10 {ECO:0000313|EMBL:ORE92483.1,
RC   ECO:0000313|Proteomes:UP000192401};
RA   Lai Q., Li G., Shao Z.;
RT   "Stappia sp. 22II-S9-Z10 Genome Sequencing.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-phospho-D-ribosylamine + ATP + glycine = ADP + H(+) +
CC         N(1)-(5-phospho-D-ribosyl)glycinamide + phosphate;
CC         Xref=Rhea:RHEA:17453, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57305, ChEBI:CHEBI:58089,
CC         ChEBI:CHEBI:58457, ChEBI:CHEBI:456216; EC=6.3.4.13;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00138};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-
CC       ribose 1-diphosphate: step 2/2. {ECO:0000256|HAMAP-Rule:MF_00138}.
CC   -!- SIMILARITY: Belongs to the GARS family. {ECO:0000256|HAMAP-
CC       Rule:MF_00138}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ORE92483.1}.
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DR   EMBL; AQRB01000005; ORE92483.1; -; Genomic_DNA.
DR   UniPathway; UPA00074; UER00125.
DR   Proteomes; UP000192401; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004637; F:phosphoribosylamine-glycine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.90.600.10; -; 1.
DR   HAMAP; MF_00138; GARS; 1.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR020561; PRibGlycinamid_synth_ATP-grasp.
DR   InterPro; IPR000115; PRibGlycinamide_synth.
DR   InterPro; IPR020560; PRibGlycinamide_synth_C-dom.
DR   InterPro; IPR037123; PRibGlycinamide_synth_C_sf.
DR   InterPro; IPR020559; PRibGlycinamide_synth_CS.
DR   InterPro; IPR020562; PRibGlycinamide_synth_N.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   Pfam; PF01071; GARS_A; 1.
DR   Pfam; PF02843; GARS_C; 1.
DR   Pfam; PF02844; GARS_N; 1.
DR   SMART; SM01210; GARS_C; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR00877; purD; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00184; GARS; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Complete proteome {ECO:0000313|Proteomes:UP000192401};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_00138, ECO:0000313|EMBL:ORE92483.1};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00138};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192401}.
FT   DOMAIN      109    314       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
SQ   SEQUENCE   418 AA;  42821 MW;  9046CFAA6699986F CRC64;
     MSSESGAPAG ARVLIVGSGG REHALAAAVK RSPKVAHLMV AGGPNAGLAA IAEEVTDIDA
     AAATADLVII GPEGPLAEGL ADRLRAAGRV VFGPSAEAAQ LESSKAYTKH VCAILGLPTA
     KAEIAESLED ALAALKRMGA PVVVKADGLA AGKGVVMAET MEEAEAAVRD AMDGAFGEAG
     HRVVLEEKLV GPEVSLFALS DGNVVREFAS ARDYKRAFDG DEGPNTGGMG AVSPAPGFTD
     ELAEEAMTTI VRPTLDWLAD RGTPYIGVLY AGLMLTEDGP KLIEYNVRFG DPECQIMWER
     VTSDPYELIY ATAAGTLETA PLTLSEGSAV GVVVAANGYP GPVEKGEPIR GLAEVAAAGA
     AVFHAGTRPE GGEVLSNGGR VLTVVATGAT AAEARRDVYA ALTHLDWPGG RMRTDIAR
//
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