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Database: UniProt
Entry: A0A1Y1U9R4_9TREE
LinkDB: A0A1Y1U9R4_9TREE
Original site: A0A1Y1U9R4_9TREE 
ID   A0A1Y1U9R4_9TREE        Unreviewed;      1056 AA.
AC   A0A1Y1U9R4;
DT   30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT   30-AUG-2017, sequence version 1.
DT   05-JUN-2019, entry version 11.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=BD324DRAFT_634881 {ECO:0000313|EMBL:ORX34769.1};
OS   Kockovaella imperatae.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Tremellomycetes; Tremellales; Cuniculitremaceae; Kockovaella.
OX   NCBI_TaxID=4999 {ECO:0000313|EMBL:ORX34769.1, ECO:0000313|Proteomes:UP000193218};
RN   [1] {ECO:0000313|EMBL:ORX34769.1, ECO:0000313|Proteomes:UP000193218}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL Y-17943 {ECO:0000313|EMBL:ORX34769.1,
RC   ECO:0000313|Proteomes:UP000193218};
RG   DOE Joint Genome Institute;
RA   Mondo S.J., Dannebaum R.O., Kuo R.C., Louie K.B., Bewick A.J.,
RA   Labutti K., Haridas S., Kuo A., Salamov A., Ahrendt S.R., Lau R.,
RA   Bowen B.P., Lipzen A., Sullivan W., Andreopoulos W.B., Clum A.,
RA   Lindquist E., Daum C., Northen T.R., Ramamoorthy G., Schmitz R.J.,
RA   Gryganskyi A., Culley D., Magnuson J., James T.Y., O'Malley M.A.,
RA   Stajich J.E., Spatafora J.W., Visel A., Grigoriev I.V.;
RT   "Widespread Adenine N6-methylation of Active Genes in Fungi.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ORX34769.1}.
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DR   EMBL; NBSH01000013; ORX34769.1; -; Genomic_DNA.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000193218; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000193218};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000193218};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN       92    430       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      494    925       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN      962   1033       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION       34     55       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1Y1U9R4}.
SQ   SEQUENCE   1056 AA;  118607 MW;  7C34031280523ED1 CRC64;
     MVDVSNKKRK LQGNGAVRTL EKQASFSQVL EQLEAEDDNS GDHIESSDAW PRPSVAVNDP
     ALDSITFQQI EIEEAVDPKG GPVLRLFGVN AAGNSVLAYV HGFKPYFYVA APPGFLNKDL
     EPLKDSINSA VQSAIPPVIN CAVFNRKSLW GYRGDDNVPF IKITCADAKA LPRVKGAFER
     GQIEFNGLFP AEIMTYESNI AYTLRFMIDT HVVGMNWVEI PGGKYEVLKG DDKKSLCQIE
     VSCNYKDLVS HAPEGEWLKI APLRILSFDI ECAGRKGIFP EPNIDPVIQI AAMVTRQGES
     KPFVRNVFTL NTCAHIVGSQ VLEFQNEKSL LLEWRKFIEK VDPDMIIGYN IANFDLPYLL
     DRAKALKIPD FAFLGRLKNV RSEVKDTHFS SKAYGQRDSK AVNMDGRLQL DILQVMQRDY
     KLRSYTLNAV CAQFLGEQKE DVHHSIITEL QNGTADSRRR LAVYCLKDAY LPQRLMDKLM
     SFVNYTEMAR VTGVPFNYLL SRGQQIKVVS QLYRSAKEHG YLVPALRSEG SDEQYEGATV
     IEPTKGFYDV PIATLDFASL YPSIMMAHNL CYTTLLDKAT IERLNLVEGE DFVHTPNNDY
     FATSKRRKGL LPTVLENLLA ARKRARQDLK VEKDPFKRAV LDGRQLALKI SANSVYGFTG
     ATVGKLPCLA ISSSTTAFGR QMIEFTKQEV EAEYCVKNGY DNDAKVIYGD TDSVMIRFGC
     PDLDTAMRMG AEAAELVSSK FIRPIKLEFE KVYFPYLLIS KKRYAGLYWT KPEKYDKMDT
     KGIETVRRDN CRLVSTVIET CLYKLLIDRD VRGAEDYVKH TIADLLQNKV DMSQLVITKA
     LAKADYAAKQ AHVELAERMK KRDAGSAPAL GDRVAYVIIK GIKGAAAYEK SEDPLYVLEH
     NVPIDTRYYL DNQLSKPLMR IFEPIMGERA GTLLAGEHTR TIQIATPTIG GLMKFAVKTV
     TCLGCKTPLR GKSGAVCENC RPKLPELYQK QIAHTSALQI DFARLWTQCQ RCQGSLHQDV
     ICTSADCPCF YARTARQKEV AAAVNQLDRF EKEVNW
//
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