ID A0A1Y1UPS5_9TREE Unreviewed; 1711 AA.
AC A0A1Y1UPS5;
DT 30-AUG-2017, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=DNA-directed RNA polymerase subunit {ECO:0000256|RuleBase:RU004279};
DE EC=2.7.7.6 {ECO:0000256|RuleBase:RU004279};
GN ORFNames=BD324DRAFT_254113 {ECO:0000313|EMBL:ORX40060.1};
OS Kockovaella imperatae.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cuniculitremaceae; Kockovaella.
OX NCBI_TaxID=4999 {ECO:0000313|EMBL:ORX40060.1, ECO:0000313|Proteomes:UP000193218};
RN [1] {ECO:0000313|EMBL:ORX40060.1, ECO:0000313|Proteomes:UP000193218}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL Y-17943 {ECO:0000313|EMBL:ORX40060.1,
RC ECO:0000313|Proteomes:UP000193218};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Louie K.B., Bewick A.J., Labutti K.,
RA Haridas S., Kuo A., Salamov A., Ahrendt S.R., Lau R., Bowen B.P.,
RA Lipzen A., Sullivan W., Andreopoulos W.B., Clum A., Lindquist E., Daum C.,
RA Northen T.R., Ramamoorthy G., Schmitz R.J., Gryganskyi A., Culley D.,
RA Magnuson J., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Widespread Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550,
CC ECO:0000256|RuleBase:RU004279};
CC -!- SIMILARITY: Belongs to the RNA polymerase beta' chain family.
CC {ECO:0000256|RuleBase:RU004279}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORX40060.1}.
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DR EMBL; NBSH01000002; ORX40060.1; -; Genomic_DNA.
DR STRING; 4999.A0A1Y1UPS5; -.
DR InParanoid; A0A1Y1UPS5; -.
DR OrthoDB; 169836at2759; -.
DR Proteomes; UP000193218; Unassembled WGS sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd02735; RNAP_I_Rpa1_C; 1.
DR CDD; cd01435; RNAP_I_RPA1_N; 1.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 1.10.150.390; -; 1.
DR Gene3D; 1.10.357.120; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.30.70.2850; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR Gene3D; 1.10.274.100; RNA polymerase Rpb1, domain 3; 1.
DR InterPro; IPR047107; DNA-dir_RNA_pol1_lsu_C.
DR InterPro; IPR015699; DNA-dir_RNA_pol1_lsu_N.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR042102; RNA_pol_Rpb1_3_sf.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF11; DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU004279};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU004279}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000193218};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004279};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004279}.
FT DOMAIN 390..733
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
FT REGION 271..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..321
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1711 AA; 191176 MW; C0308E9CFE3927B9 CRC64;
MDIAHPVSTE VTSLAFSFLT AEEIRSISVT KIDNPILLDN FNLPTKGGLY DPKLGPMSAK
DVCETCHLSY FACPGHFGHI DLPVPLYHPL FMTTVYRLLQ STCLYCHHFK MPEMMVQQYI
ARIQLLNAGL FKESHDVAHL MPKTQQADED EEGGGGGGAT MVPVETAAEH IVKLDDFVRY
ALHQAKKHGA EKDNYRDGVV YEERRALLEE VLKGDSSRSW RTKCSRCRAV NPTYRKERTV
KIIELELDNK QKLTNTHLGV KRREVLSDGR GLFKKDKSNR AQNGDDESSS ESGSEAKEDD
EMEENFDEEE EEEEEEDDED ILNRVTVAKT ASGKVKGAKG RNERVMSPGE VRAHLRVLFQ
KESKLCHLLY GRHGGTLRSR GNLSPTALAD MFFVDVLSVT PTRFRPPAKM GDDLFENPQN
SLLSAVITTC KRIQDLNHRL IEHAKAERGD EVLEVIDKVE GGRLFELLLE SLIKLQHDVN
SFMDSTKNPT VMAQGKLPHQ GIKQLLEKKE GLFRKHMMGK RVNYAARSVI SPDINIETNE
IGIPPVFARK LTYPEPVTAQ NVAELRQLVI NGPRQHPGAS MVQMEDGTRV SLDRTTLEQR
TAIANQLATP QSEAHASSSL GPAARNKKVF RHIRDGDIVI LNRQPTLHKP SMMCHKVKVL
LGEKTIRMHY ANCNSYNADF DGDEMNIHFP QNEVARAEAL MIANTDNQYL VPTSGKPLRG
LIQDHVVAAV HMCSKSSFFT REQYFQLIYG ALRTEDDYTG GGRILTVAPA IWKPRPMWTG
KQIVSTILLN LTPPNARGLN LTSRNKIDHA LWGREKNVDP NMSEEKTIFV DGHLVCGVLD
KSQFGASDFG LVHSVHELYG PMIANRLLGI LSRLFTKYLQ HDAFSCRMDD LTLTAEGEKL
RQDILDKASD LGTKTSIKYV GLPEDSQLDK ETQHNLDVRL EETLRDDNLM AGLDAVMQSA
FNKTTSQINN DVLPKYLVRP FPDNNMQMMT ISGAKGSKVN ASQISTLLGQ QALEGRRVPT
MVSGKTLPSF RAFDTSARAG GYVANRFLTG IRPQEYYFHC MAGREGLIDT AVKTSRSGYL
QRCLIKHLEG VKVHYDHTVR DSDLSVLQFL YGEDALDVTR SRHLQSFDFA AQNHDSLINR
YKPGAVLGKV VTDEAVDHMK KALKKPEKYE PALSKFSPSR YLGSMSETFA KQVRDYTHEN
KAGLISRKGQ SSNSSVISEK EFVSLARSRY MRGLVDPGEA VGLLASQGVG EPSTQMTLNT
FHLAGHGAAN VTLGIPRLRE IVMTASTHPM TPTMKLPIRE TIGDGDVEAF VKQVSRLTLS
QVVDKVTVTE RLSGRSDTDA RLRKYTVLLE FYPKEEYSEE YEISALQIHE ALAFNFSVKL
KKEILNEMRI TSKALSQDMA VGVGMRVREG EDEGLGARRG RDDELDDDDM DAYQAKRTAQ
ARQHEYEEDD RNEQVEDLED YVERQFEDDD EEDVDAGEKA ETDARGDALL EAFKKGSKYA
TDLHFDSHKG KSAQFELEFP ANTPKLLLVD IVERACRSAV IHEVPDIGRC MKVFDDKGEF
TRSLITEGSN LTGMHALADE LVDLDRIGSN DIAALLQTYG VEAARRAIID EVSAVFGAYG
IAVDYRHLTV IADYMTHAGG YRPFNRSGIS KKSSPLLKAS FETTVQFLSE AVLHGDFDDL
TSPAAKIVMG QPSTSGTGSF DIRAPRRMVL A
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